Basic Information:

  VIRBase ID:  

HHID00067537

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-616-3p:  MIMAT0004805          EXPH5:  NM_001144763     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-616-3p	EXPH5
miRBase Accession/Entrez ID	MIMAT0004805	23086
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	SLAC2-B//SLAC2B

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-616-3p	rs374321661 chr12:57519192    C/T rs573303396 chr12:57519190    A/C rs573303396 chr12:57519190    A/G rs760442491 chr12:57519183    C/T rs763282175 chr12:57519193    C/T rs768469143 chr12:57519184    T/C rs776483081 chr12:57519185    G/A rs368928238 chr12:57519199    A/G rs377525107 chr12:57519198    A/C rs755336783 chr12:57519200    T/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	EXPH5	chr11:108411911(-) A-I      intronic chr11:108451314(-) A-I      intronic chr11:108451334(-) A-I      intronic chr11:108458588(-) A-I      intronic chr11:108458595(-) A-I      intronic chr11:108453005(-) A-I      intronic chr11:108458572(-) A-I      intronic chr11:108458600(-) A-I      intronic chr11:108394355(-) A-I      intronic chr11:108448788(-) A-I      intronic chr11:108451043(-) A-I      intronic chr11:108394487(-) A-I      intronic chr11:108424937(-) A-I      intronic chr11:108394555(-) A-I      intronic chr11:108453084(-) A-I      intronic chr11:108394490(-) A-I      intronic chr11:108393876(-) A-I      intronic chr11:108393875(-) A-I      intronic chr11:108393862(-) A-I      intronic chr11:108391542(-) A-I      intronic chr11:108391497(-) A-I      intronic chr11:108390363(-) A-I      intronic chr11:108456790(-) A-I      intronic chr11:108456830(-) A-I      intronic chr11:108390356(-) A-I      intronic chr11:108456836(-) A-I      intronic chr11:108390244(-) A-I      intronic chr11:108456943(-) A-I      intronic chr11:108415068(-) A-I      intronic chr11:108456972(-) A-I      intronic chr11:108402053(-) A-I      intronic chr11:108396744(-) A-I      intronic chr11:108418169(-) A-I      intronic chr11:108410938(-) A-I      intronic chr11:108434932(-) A-I      intronic chr11:108444984(-) A-I      intronic chr11:108448354(-) A-I      intronic chr11:108448344(-) A-I      intronic chr11:108434915(-) A-I      intronic chr11:108415986(-) A-I      intronic chr11:108442730(-) A-I      intronic chr11:108442720(-) A-I      intronic chr11:108442663(-) A-I      intronic chr11:108441261(-) A-I      intronic chr11:108442611(-) A-I      intronic chr11:108441228(-) A-I      intronic chr11:108441215(-) A-I      intronic chr11:108441170(-) A-I      intronic chr11:108437329(-) A-I      intronic chr11:108434905(-) A-I      intronic chr11:108434893(-) A-I      intronic chr11:108434772(-) A-I      intronic chr11:108421423(-) A-I      intronic chr11:108433250(-) A-I      intronic chr11:108428184(-) A-I      intronic chr11:108425568(-) A-I      intronic chr11:108425527(-) A-I      intronic chr11:108425452(-) A-I      intronic chr11:108425444(-) A-I      intronic chr11:108425038(-) A-I      intronic chr11:108424939(-) A-I      intronic chr11:108424876(-) A-I      intronic chr11:108434928(-) A-I      intronic chr11:108455065(-) A-I      intronic chr11:108399725(-) A-I      intronic chr11:108416412(-) A-I      intronic chr11:108423882(-) A-I      intronic chr11:108399721(-) A-I      intronic chr11:108433236(-) A-I      intronic chr11:108423757(-) A-I      intronic chr11:108423743(-) A-I      intronic chr11:108453083(-) A-I      intronic chr11:108423718(-) A-I      intronic chr11:108423702(-) A-I      intronic chr11:108404620(-) A-I      intronic chr11:108415161(-) A-I      intronic chr11:108423693(-) A-I      intronic chr11:108423666(-) A-I      intronic chr11:108396762(-) A-I      intronic chr11:108396851(-) A-I      intronic chr11:108417636(-) A-I      intronic chr11:108411764(-) A-I      intronic chr11:108411760(-) A-I      intronic chr11:108397793(-) A-I      intronic chr11:108402135(-) A-I      intronic chr11:108393737(-) A-I      intronic chr11:108400230(-) A-I      intronic chr11:108418075(-) A-I      intronic chr11:108400514(-) A-I      intronic chr11:108445029(-) A-I      intronic chr11:108400495(-) A-I      intronic chr11:108441254(-) A-I      intronic chr11:108397862(-) A-I      intronic chr11:108400488(-) A-I      intronic chr11:108456949(-) A-I      intronic chr11:108458620(-) A-I      intronic chr11:108400484(-) A-I      intronic chr11:108399612(-) A-I      intronic chr11:108399594(-) A-I      intronic chr11:108399590(-) A-I      intronic chr11:108397881(-) A-I      intronic chr11:108442617(-) A-I      intronic chr11:108418193(-) A-I      intronic chr11:108448353(-) A-I      intronic chr11:108393733(-) A-I      intronic chr11:108400198(-) A-I      intronic chr11:108400218(-) A-I      intronic chr11:108446579(-) A-I      intronic chr11:108418101(-) A-I      intronic chr11:108451808(-) A-I      intronic chr11:108402088(-) A-I      intronic chr11:108434933(-) A-I      intronic chr11:108445059(-) A-I      intronic chr11:108425054(-) A-I      intronic chr11:108450973(-) A-I      intronic chr11:108424955(-) A-I      intronic chr11:108455158(-) A-I      intronic chr11:108404156(-) A-I      intronic chr11:108443545(-) A-I      intronic chr11:108393732(-) A-I      intronic chr11:108415144(-) A-I      intronic chr11:108444909(-) A-I      intronic chr11:108451073(-) A-I      intronic chr11:108416506(-) A-I      intronic chr11:108455061(-) A-I      intronic chr11:108446651(-) A-I      intronic chr11:108402141(-) A-I      intronic chr11:108448505(-) A-I      intronic chr11:108433076(-) A-I      intronic chr11:108456798(-) A-I      intronic chr11:108447985(-) A-I      intronic chr11:108428031(-) A-I      intronic chr11:108446785(-) A-I      intronic chr11:108416616(-) A-I      intronic chr11:108427328(-) A-I      intronic chr11:108415113(-) A-I      intronic chr11:108443519(-) A-I      intronic chr11:108416548(-) A-I      intronic chr11:108428509(-) A-I      intronic chr11:108391458(-) A-I      intronic chr11:108442653(-) A-I      intronic chr11:108397984(-) A-I      intronic chr11:108418103(-) A-I      intronic chr11:108410856(-) A-I      intronic chr11:108448864(-) A-I      intronic chr11:108454913(-) A-I      intronic chr11:108441241(-) A-I      intronic chr11:108393802(-) A-I      intronic chr11:108425001(-) A-I      intronic chr11:108456786(-) A-I      intronic chr11:108390555(-) A-I      intronic chr11:108446589(-) A-I      intronic chr11:108428474(-) A-I      intronic chr11:108428058(-) A-I      intronic chr11:108428196(-) A-I      intronic chr11:108418174(-) A-I      intronic chr11:108396849(-) A-I      intronic chr11:108425445(-) A-I      intronic chr11:108433153(-) A-I      intronic chr11:108399457(-) A-I      intronic chr11:108434841(-) A-I      intronic chr11:108416508(-) A-I      intronic chr11:108433214(-) A-I      intronic chr11:108421351(-) A-I      intronic chr11:108402062(-) A-I      intronic chr11:108425456(-) A-I      intronic chr11:108425529(-) A-I      intronic chr11:108433433(-) A-I      intronic chr11:108394491(-) A-I      intronic chr11:108434902(-) A-I      intronic chr11:108393688(-) A-I      intronic chr11:108443692(-) A-I      intronic chr11:108454386(-) A-I      intronic chr11:108418168(-) A-I      intronic chr11:108400171(-) A-I      intronic chr11:108433260(-) A-I      intronic chr11:108412725(-) A-I      intronic chr11:108396739(-) A-I      intronic chr11:108444767(-) A-I      intronic chr11:108446629(-) A-I      intronic chr11:108446582(-) A-I      intronic chr11:108444908(-) A-I      intronic chr11:108444886(-) A-I      intronic chr11:108423672(-) A-I      intronic chr11:108441106(-) A-I      intronic chr11:108425446(-) A-I      intronic chr11:108396750(-) A-I      intronic chr11:108415114(-) A-I      intronic chr11:108425073(-) A-I      intronic chr11:108397855(-) A-I      intronic chr11:108448148(-) A-I      intronic chr11:108454946(-) A-I      intronic chr11:108434789(-) A-I      intronic chr11:108425469(-) A-I      intronic chr11:108428126(-) A-I      intronic chr11:108418094(-) A-I      intronic chr11:108425000(-) A-I      intronic chr11:108455118(-) A-I      intronic chr11:108411770(-) A-I      intronic chr11:108435765(-) A-I      intronic chr11:108418166(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	EXPH5	chr11:108416506(-) A-I intron -    21960545 chr11:108447856(-) A-I intron -    21960545 chr11:108447919(-) A-I intron -    21960545 chr11:108448066(-) A-I intron -    21960545 chr11:108448073(-) A-I intron -    21960545 chr11:108428058(-) A-G intron -    22484847 chr11:108447985(-) A-G intron -    22484847 chr11:108448505(-) A-G intron -    22484847 chr11:108454913(-) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	EXPH5	chr11:108379867-108379868(-) m6A 3'UTR       27773535 chr11:108379896-108379897(-) m6A 3'UTR       27773535 chr11:108380085-108380086(-) m6A 3'UTR       24284625//27773535 chr11:108380104-108380105(-) m6A 3'UTR       24284625//27773535 chr11:108380212-108380213(-) m6A 3'UTR       24284625//24981863//27773535//22608085 chr11:108380269-108380270(-) m6A CDS       24284625//24209618//24981863//27773535//22575960//22608085 chr11:108380321-108380322(-) m6A CDS       24284625//24209618//24981863//27773535//22575960//22608085 chr11:108380339-108380340(-) m6A CDS       24284625//24209618//24981863//27773535//22575960//22608085 chr11:108380371-108380372(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr11:108380450-108380451(-) m6A CDS       24284625//24981863//27773535//22608085 chr11:108380480-108380481(-) m6A CDS       24284625//24981863//27773535//22608085 chr11:108380497-108380498(-) m6A CDS       24284625//24981863//27773535//22608085 chr11:108380557-108380558(-) m6A CDS       24284625//24209618//24981863//27773535//22608085 chr11:108380587-108380588(-) m6A CDS       24284625//24981863//27773535//22608085 chr11:108380619-108380620(-) m6A CDS       24284625//24981863//27773535//22575960//22608085 chr11:108380625-108380626(-) m6A CDS       24284625//24981863//27773535//27371828//22575960//22608085 chr11:108380671-108380672(-) m6A CDS       24284625//24981863//27773535//27371828//22575960//22608085 chr11:108380875-108380876(-) m6A CDS       24981863 chr11:108381187-108381188(-) m6A CDS       27773535 chr11:108381221-108381222(-) m6A CDS       27773535 chr11:108381625-108381626(-) m6A CDS       22608085 chr11:108381647-108381648(-) m6A CDS       22608085 chr11:108381652-108381653(-) m6A CDS       22608085 chr11:108381666-108381667(-) m6A CDS       22608085 chr11:108381685-108381686(-) m6A CDS       22608085 chr11:108381738-108381739(-) m6A CDS       24981863//22608085 chr11:108381765-108381766(-) m6A CDS       24981863//22608085 chr11:108381773-108381774(-) m6A CDS       24981863//22608085 chr11:108382311-108382312(-) m6A CDS       22608085 chr11:108382346-108382347(-) m6A CDS       22608085 chr11:108382371-108382372(-) m6A CDS       22608085 chr11:108382377-108382378(-) m6A CDS       22608085 chr11:108382456-108382457(-) m6A CDS       22608085 chr11:108382560-108382561(-) m6A CDS       24981863//22608085 chr11:108382586-108382587(-) m6A CDS       24981863//22608085 chr11:108382607-108382608(-) m6A CDS       24981863//27371828//22608085 chr11:108382682-108382683(-) m6A CDS       24284625//24981863//27371828//22608085 chr11:108382699-108382700(-) m6A CDS       24284625//24981863//22608085 chr11:108382973-108382974(-) m6A CDS       22608085 chr11:108383030-108383031(-) m6A CDS       22608085 chr11:108383042-108383043(-) m6A CDS       22608085 chr11:108383191-108383192(-) m6A CDS       24981863//22608085 chr11:108383268-108383269(-) m6A CDS       24981863//22608085 chr11:108383619-108383620(-) m6A CDS       - chr11:108383760-108383761(-) m6A CDS       24981863//27773535//22608085 chr11:108383781-108383782(-) m6A CDS       24981863//27773535//22608085 chr11:108383788-108383789(-) m6A CDS       24981863//27773535//22608085 chr11:108383824-108383825(-) m6A CDS       24981863//27773535//22608085 chr11:108383831-108383832(-) m6A CDS       24981863//27773535//22608085 chr11:108383854-108383855(-) m6A CDS       24981863//27773535//22608085 chr11:108383987-108383988(-) m6A CDS       24284625//24981863//27773535//27371828//22608085 chr11:108384023-108384024(-) m6A CDS       24284625//24981863//27773535//27371828//22608085 chr11:108384036-108384037(-) m6A CDS       24284625//24981863//27773535//27371828//22608085 chr11:108384075-108384076(-) m6A CDS       24284625//24981863//27773535//27371828//22608085 chr11:108384080-108384081(-) m6A CDS       24284625//24981863//27773535//27371828//22608085 chr11:108384101-108384102(-) m6A CDS       24284625//24981863//27773535//27371828//22608085 chr11:108384128-108384129(-) m6A CDS       24284625//24981863//27773535//22608085 chr11:108384348-108384349(-) m6A CDS       24284625//24981863//22608085 chr11:108384369-108384370(-) m6A CDS       24284625//24981863//22608085 chr11:108384401-108384402(-) m6A CDS       24981863//22608085 chr11:108384428-108384429(-) m6A CDS       24981863//22608085 chr11:108384522-108384523(-) m6A CDS       22608085 chr11:108384618-108384619(-) m6A CDS       24981863//27773535//22608085 chr11:108384649-108384650(-) m6A CDS       24284625//24981863//27773535//22608085 chr11:108384716-108384717(-) m6A CDS       24284625//25456834//24981863//27773535//22608085 chr11:108384775-108384776(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr11:108384805-108384806(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr11:108384820-108384821(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr11:108384893-108384894(-) m6A CDS       24284625//24981863//27773535//22575960//22608085 chr11:108384902-108384903(-) m6A CDS       24284625//24981863//27773535//22575960//22608085 chr11:108385082-108385083(-) m6A CDS       24981863//22608085 chr11:108385091-108385092(-) m6A CDS       24981863//27773535//22608085 chr11:108385112-108385113(-) m6A CDS       24981863//27773535//22608085 chr11:108385137-108385138(-) m6A CDS       24981863//27773535//22608085 chr11:108385335-108385336(-) m6A CDS       24284625//24981863//27773535//22608085 chr11:108385362-108385363(-) m6A CDS       24284625//24981863//27773535//22608085 chr11:108385377-108385378(-) m6A CDS       24284625//24981863//27773535//22608085 chr11:108385398-108385399(-) m6A CDS       24284625//24981863//27773535//22575960//22608085 chr11:108385405-108385406(-) m6A CDS       24284625//24981863//27773535//22575960//22608085 chr11:108385437-108385438(-) m6A CDS       24284625//24981863//27773535//22575960//22608085 chr11:108385450-108385451(-) m6A CDS       24284625//24981863//27773535//22575960//22608085 chr11:108385480-108385481(-) m6A CDS       24284625//24981863//27773535//22608085 chr11:108385515-108385516(-) m6A CDS       24284625//24981863//27773535//22608085 chr11:108385539-108385540(-) m6A CDS       24284625//24981863//27773535//22608085 chr11:108385567-108385568(-) m6A CDS       24284625//24981863//27773535//22608085 chr11:108464344-108464345(-) m6A 5'UTR//intron       24981863//22608085 chr11:108464461-108464462(-) m6A 5'UTR       22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-616-3p	Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
	EXPH5	Chromatin K562 cells     - Cytosol K562 cells     - Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Membrane K562 cells     - Nucleoplasm K562 cells     - Nucleus Colon cancer cells     24393600 Nucleus K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-616-3p
Interactor2: EXPH5

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	CDS
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.