Detail Information

Basic Information:


  VIRBase ID:  

HHID00067526

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-616-3p:           TRA2B:      

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Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-616-3p TRA2B
miRBase
Accession/Entrez ID		 MIMAT0004805 6434
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - Htra2-beta//PPP1R156//SFRS10//SRFS10//TRA2-BETA//TRAN2B

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-616-3p
rs374321661 chr12:57519192    C/T
rs573303396 chr12:57519190    A/C
rs573303396 chr12:57519190    A/G
rs760442491 chr12:57519183    C/T
rs763282175 chr12:57519193    C/T
rs768469143 chr12:57519184    T/C
rs776483081 chr12:57519185    G/A
rs368928238 chr12:57519199    A/G
rs377525107 chr12:57519198    A/C
rs755336783 chr12:57519200    T/C

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR TRA2B
chr3:185636666(-) A-I      intronic
chr3:185640905(-) A-I      intronic
chr3:185639363(-) A-I      intronic
chr3:185638583(-) A-I      intronic
chr3:185636724(-) A-I      intronic
chr3:185636682(-) A-I      intronic
chr3:185636669(-) A-I      intronic
chr3:185638500(-) A-I      intronic
chr3:185636646(-) A-I      intronic
chr3:185636632(-) A-I      intronic
chr3:185636627(-) A-I      intronic
chr3:185636623(-) A-I      intronic
chr3:185636579(-) A-I      intronic
chr3:185638501(-) A-I      intronic
chr3:185638533(-) A-I      intronic
chr3:185638534(-) A-I      intronic
chr3:185638496(-) A-I      intronic
chr3:185638576(-) A-I      intronic
chr3:185638589(-) A-I      intronic
chr3:185636659(-) A-I      intronic
chr3:185639388(-) A-I      intronic
chr3:185638156(-) A-I      intronic
chr3:185640908(-) A-I      intronic
chr3:185638603(-) A-I      intronic
chr3:185641007(-) A-I      intronic
chr3:185636629(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED TRA2B
chr3:185636644(-) T-A intron -    22484847
chr3:185638451(-) T-G intron -    22484847
chr3:185638612(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase TRA2B
chr3:185637242-185637243(-) m6A 3'UTR//CDS//exon//intron       24981863//26404942
chr3:185638912-185638913(-) m6A 3'UTR//CDS//exon       24981863//26404942//27773535
chr3:185639806-185639807(-) m6A 3'UTR//CDS//exon       26404942//27773535
chr3:185639842-185639843(-) m6A 3'UTR//CDS//exon       26404942//27773535
chr3:185641710-185641711(-) Gm 3'UTR//CDS//exon       -
chr3:185644542-185644543(-) m6A exon//intron       27371828//27773536//22575960
chr3:185649511-185649512(-) m6A 3'UTR//exon//intron       24981863//27773535
chr3:185649626-185649627(-) m1A CDS//exon//intron       26863196
chr3:185652262-185652263(-) m6A exon//intron       24209618//27371828
chr3:185652297-185652298(-) m6A exon//intron       27371828
chr3:185655132-185655133(-) m6A exon//intron       -
chr3:185655186-185655187(-) m6A exon//intron       24981863//27371828//27773536
chr3:185655625-185655626(-) m6A 5'UTR//CDS//exon       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-616-3p
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
TRA2B
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol HCC cell line (HepG2)|K562 cells     -
Exosome Blood     -
Insoluble cytoplasm HCC cell line (HepG2)     -
Membrane HCC cell line (HepG2)     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -
Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-616-3p
Interactor2: TRA2B

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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