Basic Information:

  VIRBase ID:  

HHID00067525

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-616-3p:  MIMAT0004805          RORA:  NM_134261     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-616-3p	RORA
miRBase Accession/Entrez ID	MIMAT0004805	6095
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	IDDECA//NR1F1//ROR1//ROR2//ROR3//RZR-ALPHA//RZRA

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-616-3p	rs374321661 chr12:57519192    C/T rs573303396 chr12:57519190    A/C rs573303396 chr12:57519190    A/G rs760442491 chr12:57519183    C/T rs763282175 chr12:57519193    C/T rs768469143 chr12:57519184    T/C rs776483081 chr12:57519185    G/A rs368928238 chr12:57519199    A/G rs377525107 chr12:57519198    A/C rs755336783 chr12:57519200    T/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	RORA	chr15:61358798(-) A-I      intronic chr15:61203207(-) A-I      intronic chr15:61358803(-) A-I      intronic chr15:61470078(-) A-I      intronic chr15:61203226(-) A-I      intronic chr15:60785414(-) A-I      3'UTR chr15:61203192(-) A-I      intronic chr15:61358801(-) A-I      intronic chr15:61167345(-) A-I      intronic chr15:61358793(-) A-I      intronic chr15:60816107(-) A-I      intronic chr15:60816073(-) A-I      intronic chr15:61413330(-) A-I      intronic chr15:61167370(-) A-I      intronic chr15:61413322(-) A-I      intronic chr15:61354179(-) A-I      intronic chr15:61297596(-) A-I      intronic chr15:61148078(-) A-I      intronic chr15:61167351(-) A-I      intronic chr15:61167375(-) A-I      intronic chr15:61167377(-) A-I      intronic chr15:61290791(-) A-I      intronic chr15:61167367(-) A-I      intronic chr15:61358790(-) A-I      intronic chr15:61358764(-) A-I      intronic chr15:61358763(-) A-I      intronic chr15:60813508(-) A-I      intronic chr15:61290776(-) A-I      intronic chr15:61290772(-) A-I      intronic chr15:61290768(-) A-I      intronic chr15:61290767(-) A-I      intronic chr15:61290764(-) A-I      intronic chr15:61204405(-) A-I      intronic chr15:61204037(-) A-I      intronic chr15:61203213(-) A-I      intronic chr15:61477005(-) A-I      intronic chr15:61204709(-) A-I      intronic chr15:61476993(-) A-I      intronic chr15:61476927(-) A-I      intronic chr15:61473132(-) A-I      intronic chr15:61204841(-) A-I      intronic chr15:61460458(-) A-I      intronic chr15:61460445(-) A-I      intronic chr15:60853413(-) A-I      intronic chr15:60853392(-) A-I      intronic chr15:61431286(-) A-I      intronic chr15:60852781(-) A-I      intronic chr15:60852774(-) A-I      intronic chr15:60852701(-) A-I      intronic chr15:60842327(-) A-I      intronic chr15:60841074(-) A-I      intronic chr15:60841006(-) A-I      intronic chr15:60841001(-) A-I      intronic chr15:60840993(-) A-I      intronic chr15:60840969(-) A-I      intronic chr15:60814969(-) A-I      intronic chr15:60814968(-) A-I      intronic chr15:60814962(-) A-I      intronic chr15:60814954(-) A-I      intronic chr15:60814821(-) A-I      intronic chr15:60814803(-) A-I      intronic chr15:60814756(-) A-I      intronic chr15:60814755(-) A-I      intronic chr15:60814728(-) A-I      intronic chr15:60814664(-) A-I      intronic chr15:61413114(-) A-I      intronic chr15:61413109(-) A-I      intronic chr15:61413107(-) A-I      intronic chr15:61413104(-) A-I      intronic chr15:61203934(-) A-I      intronic chr15:60835786(-) A-I      intronic chr15:61412881(-) A-I      intronic chr15:61374566(-) A-I      intronic chr15:61392551(-) A-I      intronic chr15:61392546(-) A-I      intronic chr15:61392482(-) A-I      intronic chr15:61392466(-) A-I      intronic chr15:61392456(-) A-I      intronic chr15:61392455(-) A-I      intronic chr15:61390545(-) A-I      intronic chr15:61374657(-) A-I      intronic chr15:61374636(-) A-I      intronic chr15:61370649(-) A-I      intronic chr15:61358754(-) A-I      intronic chr15:61358746(-) A-I      intronic chr15:61358737(-) A-I      intronic chr15:61316868(-) A-I      intronic chr15:61316843(-) A-I      intronic chr15:61316832(-) A-I      intronic chr15:61316829(-) A-I      intronic chr15:61379179(-) A-I      intronic chr15:61306119(-) A-I      intronic chr15:61306111(-) A-I      intronic chr15:61297531(-) A-I      intronic chr15:61297512(-) A-I      intronic chr15:61297496(-) A-I      intronic chr15:61297487(-) A-I      intronic chr15:61470084(-) A-I      intronic chr15:61465993(-) A-I      intronic chr15:61290801(-) A-I      intronic chr15:61290420(-) A-I      intronic chr15:61392568(-) A-I      intronic chr15:61288945(-) A-I      intronic chr15:61288920(-) A-I      intronic chr15:61288916(-) A-I      intronic chr15:61204365(-) A-I      intronic chr15:61204136(-) A-I      intronic chr15:61204031(-) A-I      intronic chr15:61203401(-) A-I      intronic chr15:61203366(-) A-I      intronic chr15:61203357(-) A-I      intronic chr15:61203338(-) A-I      intronic chr15:61203335(-) A-I      intronic chr15:60854208(-) A-I      intronic chr15:61203266(-) A-I      intronic chr15:61203234(-) A-I      intronic chr15:61288513(-) A-I      intronic chr15:61204036(-) A-I      intronic chr15:61203199(-) A-I      intronic chr15:61203155(-) A-I      intronic chr15:61203132(-) A-I      intronic chr15:61203131(-) A-I      intronic chr15:61193644(-) A-I      intronic chr15:61193495(-) A-I      intronic chr15:61193482(-) A-I      intronic chr15:61359382(-) A-I      intronic chr15:61192905(-) A-I      intronic chr15:60964259(-) A-I      intronic chr15:60950545(-) A-I      intronic chr15:60914555(-) A-I      intronic chr15:60914553(-) A-I      intronic chr15:60914169(-) A-I      intronic chr15:60914090(-) A-I      intronic chr15:60914084(-) A-I      intronic chr15:60914081(-) A-I      intronic chr15:60871238(-) A-I      intronic chr15:61193428(-) A-I      intronic chr15:60871230(-) A-I      intronic chr15:60871146(-) A-I      intronic chr15:61359507(-) A-I      intronic chr15:60871101(-) A-I      intronic chr15:60871087(-) A-I      intronic chr15:60869841(-) A-I      intronic chr15:60869840(-) A-I      intronic chr15:60869731(-) A-I      intronic chr15:60869726(-) A-I      intronic chr15:60869686(-) A-I      intronic chr15:60869660(-) A-I      intronic chr15:60853476(-) A-I      intronic chr15:61507355(-) A-I      intronic chr15:61295310(-) A-I      intronic chr15:60854371(-) A-I      intronic chr15:61359510(-) A-I      intronic chr15:61290734(-) A-I      intronic chr15:60852776(-) A-I      intronic chr15:61390575(-) A-I      intronic chr15:60915007(-) A-I      intronic chr15:60855013(-) A-I      intronic chr15:60914595(-) A-I      intronic chr15:61288853(-) A-I      intronic chr15:60871139(-) A-I      intronic chr15:60871131(-) A-I      intronic chr15:61035378(-) A-I      intronic chr15:61460490(-) A-I      intronic chr15:61297643(-) A-I      intronic chr15:60962534(-) A-I      intronic chr15:61515262(-) A-I      intronic chr15:61204538(-) A-I      intronic chr15:60871137(-) A-I      intronic chr15:61460737(-) A-I      intronic chr15:60854545(-) A-I      intronic chr15:60842406(-) A-I      intronic chr15:60842445(-) A-I      intronic chr15:61473111(-) A-I      intronic chr15:61010192(-) A-I      intronic chr15:61473054(-) A-I      intronic chr15:61204623(-) A-I      intronic chr15:61284045(-) A-I      intronic chr15:61359589(-) A-I      intronic chr15:61413119(-) A-I      intronic chr15:61290441(-) A-I      intronic chr15:61507279(-) A-I      intronic chr15:61468756(-) A-I      intronic chr15:61514109(-) A-I      intronic chr15:61468738(-) A-I      intronic chr15:60994663(-) A-I      intronic chr15:61306068(-) A-I      intronic chr15:61476954(-) A-I      intronic chr15:61204007(-) A-I      intronic chr15:60813552(-) A-I      intronic chr15:61147928(-) A-I      intronic chr15:61288391(-) A-I      intronic chr15:60934967(-) A-I      intronic chr15:61373895(-) A-I      intronic chr15:61359592(-) A-I      intronic chr15:61342063(-) A-I      intronic chr15:61010211(-) A-I      intronic chr15:61035487(-) A-I      intronic chr15:61304922(-) A-I      intronic chr15:61507361(-) A-I      intronic chr15:61507196(-) A-I      intronic chr15:61507131(-) A-I      intronic chr15:61507129(-) A-I      intronic chr15:61504785(-) A-I      intronic chr15:61478740(-) A-I      intronic chr15:61204406(-) A-I      intronic chr15:61359407(-) A-I      intronic chr15:60796273(-) A-I      intronic chr15:60813623(-) A-I      intronic chr15:60962573(-) A-I      intronic chr15:60800846(-) A-I      intronic chr15:60816100(-) A-I      intronic chr15:61204190(-) A-I      intronic chr15:61379129(-) A-I      intronic chr15:61412633(-) A-I      intronic chr15:61390815(-) A-I      intronic chr15:61316916(-) A-I      intronic chr15:61476966(-) A-I      intronic chr15:60962635(-) A-I      intronic chr15:60796206(-) A-I      intronic chr15:61148087(-) A-I      intronic chr15:61203222(-) A-I      intronic chr15:61204388(-) A-I      intronic chr15:61155069(-) A-I      intronic chr15:60937705(-) A-I      intronic chr15:61504737(-) A-I      intronic chr15:61511606(-) A-I      intronic chr15:61507142(-) A-I      intronic chr15:60798509(-) A-I      intronic chr15:60869608(-) A-I      intronic chr15:61192816(-) A-I      intronic chr15:60839708(-) A-I      intronic chr15:60816105(-) A-I      intronic chr15:61129298(-) A-I      intronic chr15:61204191(-) A-I      intronic chr15:60798406(-) A-I      intronic chr15:60796660(-) A-I      intronic chr15:61203141(-) A-I      intronic chr15:61288475(-) A-I      intronic chr15:60915043(-) A-I      intronic chr15:61511664(-) A-I      intronic chr15:60869677(-) A-I      intronic chr15:61204389(-) A-I      intronic chr15:60842350(-) A-I      intronic chr15:61203406(-) A-I      intronic chr15:61460520(-) A-I      intronic chr15:61367164(-) A-I      intronic chr15:61284019(-) A-I      intronic chr15:61154072(-) A-I      intronic chr15:61193443(-) A-I      intronic chr15:61146469(-) A-I      intronic chr15:60796659(-) A-I      intronic chr15:61305124(-) A-I      intronic chr15:61203140(-) A-I      intronic chr15:61285612(-) A-I      intronic chr15:61316485(-) A-I      intronic chr15:60796699(-) A-I      intronic chr15:60915188(-) A-I      intronic chr15:60915204(-) A-I      intronic chr15:61155068(-) A-I      intronic chr15:61370684(-) A-I      intronic chr15:61000455(-) A-I      intronic chr15:61288366(-) A-I      intronic chr15:60814812(-) A-I      intronic chr15:61413340(-) A-I      intronic chr15:61236659(-) A-I      intronic chr15:60869598(-) A-I      intronic chr15:61288407(-) A-I      intronic chr15:60854546(-) A-I      intronic chr15:61390741(-) A-I      intronic chr15:61460730(-) A-I      intronic chr15:61203179(-) A-I      intronic chr15:61203171(-) A-I      intronic chr15:61147948(-) A-I      intronic chr15:61347311(-) A-I      intronic chr15:61392575(-) A-I      intronic chr15:61204497(-) A-I      intronic chr15:60814934(-) A-I      intronic chr15:60915023(-) A-I      intronic chr15:61204606(-) A-I      intronic chr15:61204831(-) A-I      intronic chr15:61468808(-) A-I      intronic chr15:61203423(-) A-I      intronic chr15:61203329(-) A-I      intronic chr15:61413316(-) A-I      intronic chr15:60869599(-) A-I      intronic chr15:61465963(-) A-I      intronic chr15:61473227(-) A-I      intronic chr15:61467854(-) A-I      intronic chr15:61203218(-) A-I      intronic chr15:60842378(-) A-I      intronic chr15:60804732(-) A-I      intronic chr15:61278010(-) A-I      intronic chr15:61035473(-) A-I      intronic chr15:61412709(-) A-I      intronic chr15:60796489(-) A-I      intronic chr15:60852708(-) A-I      intronic chr15:61204764(-) A-I      intronic chr15:61203240(-) A-I      intronic chr15:61290735(-) A-I      intronic chr15:60842442(-) A-I      intronic chr15:61469942(-) A-I      intronic chr15:61460731(-) A-I      intronic chr15:61204362(-) A-I      intronic chr15:60854384(-) A-I      intronic chr15:61373944(-) A-I      intronic chr15:61204344(-) A-I      intronic chr15:61373839(-) A-I      intronic chr15:60840909(-) A-I      intronic chr15:61153804(-) A-I      intronic chr15:60963758(-) A-I      intronic chr15:61204407(-) A-I      intronic chr15:60842342(-) A-I      intronic chr15:61288408(-) A-I      intronic chr15:60842475(-) A-I      intronic chr15:60935293(-) A-I      intronic chr15:61460466(-) A-I      intronic chr15:61511662(-) A-I      intronic chr15:61290806(-) A-I      intronic chr15:61370448(-) A-I      intronic chr15:60852825(-) A-I      intronic chr15:60915079(-) A-I      intronic chr15:61288543(-) A-I      intronic chr15:61347174(-) A-I      intronic chr15:61219780(-) A-I      intronic chr15:61204759(-) A-I      intronic chr15:61147918(-) A-I      intronic chr15:61298439(-) A-I      intronic chr15:61203239(-) A-I      intronic chr15:60813649(-) A-I      intronic chr15:61412642(-) A-I      intronic chr15:61204505(-) A-I      intronic chr15:60852812(-) A-I      intronic chr15:61359493(-) A-I      intronic chr15:61203959(-) A-I      intronic chr15:60869595(-) A-I      intronic chr15:61412655(-) A-I      intronic chr15:60973486(-) A-I      intronic chr15:61370601(-) A-I      intronic chr15:61504736(-) A-I      intronic chr15:61373885(-) A-I      intronic chr15:60796663(-) A-I      intronic chr15:61204159(-) A-I      intronic chr15:60861546(-) A-I      intronic chr15:61507278(-) A-I      intronic chr15:61288452(-) A-I      intronic chr15:60869586(-) A-I      intronic chr15:61295141(-) A-I      intronic chr15:61290501(-) A-I      intronic chr15:61193431(-) A-I      intronic chr15:61374601(-) A-I      intronic chr15:60796558(-) A-I      intronic chr15:60854275(-) A-I      intronic chr15:61295136(-) A-I      intronic chr15:61373817(-) A-I      intronic chr15:60842450(-) A-I      intronic chr15:61460524(-) A-I      intronic chr15:61062827(-) A-I      intronic chr15:61204001(-) A-I      intronic chr15:60841119(-) A-I      intronic chr15:60854652(-) A-I      intronic chr15:60861545(-) A-I      intronic chr15:61297516(-) A-I      intronic chr15:60962682(-) A-I      intronic chr15:61295163(-) A-I      intronic chr15:60869760(-) A-I      intronic chr15:60841075(-) A-I      intronic chr15:61306163(-) A-I      intronic chr15:61431280(-) A-I      intronic chr15:61193540(-) A-I      intronic chr15:61204890(-) A-I      intronic chr15:61283929(-) A-I      intronic chr15:61203175(-) A-I      intronic chr15:61507354(-) A-I      intronic chr15:61370630(-) A-I      intronic chr15:61316922(-) A-I      intronic chr15:61465951(-) A-I      intronic chr15:61204127(-) A-I      intronic chr15:61148019(-) A-I      intronic chr15:61460566(-) A-I      intronic chr15:61353440(-) A-I      intronic chr15:60814844(-) A-I      intronic chr15:61204569(-) A-I      intronic chr15:61175217(-) A-I      intronic chr15:61203989(-) A-I      intronic chr15:61473137(-) A-I      intronic chr15:61477089(-) A-I      intronic chr15:61284022(-) A-I      intronic chr15:60871167(-) A-I      intronic chr15:61290769(-) A-I      intronic chr15:61297513(-) A-I      intronic chr15:61460747(-) A-I      intronic chr15:61317017(-) A-I      intronic chr15:60914591(-) A-I      intronic chr15:60842413(-) A-I      intronic chr15:60958591(-) A-I      intronic chr15:61390678(-) A-I      intronic chr15:61146206(-) A-I      intronic chr15:61280378(-) A-I      intronic chr15:61288474(-) A-I      intronic chr15:61370602(-) A-I      intronic chr15:60914594(-) A-I      intronic chr15:60796487(-) A-I      intronic chr15:61203337(-) A-I      intronic chr15:60814874(-) A-I      intronic chr15:60852832(-) A-I      intronic chr15:61204366(-) A-I      intronic chr15:61370434(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	RORA	chr15:60796558(-) A-I intron -    22327324 chr15:60798406(-) A-I intron -    22327324 chr15:60798509(-) A-I intron -    22327324 chr15:60854384(-) A-G intron -    22484847 chr15:60854545(-) A-G intron -    22484847 chr15:60854546(-) A-G intron -    22484847 chr15:60869760(-) A-G intron -    22484847 chr15:60871137(-) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	RORA	chr15:60780547-60780548(-) m6A 3'UTR       27773535 chr15:60780591-60780592(-) m6A 3'UTR       27773535 chr15:60789325-60789326(-) m6A 3'UTR       26404942//27773535//27371828//22608085 chr15:60789428-60789429(-) m6A 3'UTR       27773535//27371828//22608085 chr15:60789475-60789476(-) m6A 3'UTR       27773535//27371828//22608085 chr15:60789490-60789491(-) m6A 3'UTR       24981863//27773535//27371828//22608085 chr15:60789499-60789500(-) m6A 3'UTR       24981863//27773535//27371828//22608085 chr15:60789558-60789559(-) m6A 3'UTR       24981863//27773535//27371828//22608085 chr15:60789581-60789582(-) m6A 3'UTR       24981863//27773535//27371828//22608085 chr15:60789603-60789604(-) m6A 3'UTR       24981863//27773535//27371828//22608085 chr15:60789612-60789613(-) m6A 3'UTR       24981863//27773535//27371828//22608085 chr15:60789735-60789736(-) m6A CDS       26404942//27773535//27371828//22608085 chr15:60797719-60797720(-) m6A CDS       27773535 chr15:60797744-60797745(-) m6A CDS       27773535 chr15:60797789-60797790(-) m6A CDS       27773535 chr15:60803454-60803455(-) m6A CDS//exon       27773535 chr15:60803518-60803519(-) m6A 3'UTR//CDS//exon       24981863//27773535//22608085 chr15:60803524-60803525(-) m6A 3'UTR//CDS//exon       24981863//27773535//22608085 chr15:60803555-60803556(-) m6A 3'UTR//CDS//exon       24981863//27773535//22608085 chr15:60803573-60803574(-) m6A 3'UTR//CDS//exon       24981863//27773535//22608085 chr15:60803600-60803601(-) m6A 3'UTR//CDS//exon       27773535 chr15:60803659-60803660(-) m6A 3'UTR//CDS//exon       27773535 chr15:60803758-60803759(-) m6A 3'UTR//CDS//exon       27773535 chr15:60803783-60803784(-) m6A 3'UTR//CDS//exon       27773535 chr15:60804235-60804236(-) m6A exon//intron       27773535 chr15:60804276-60804277(-) m6A exon//intron       27773535 chr15:60884654-60884655(-) m6A 5'UTR//exon//intron       27371828 chr15:61468414-61468415(-) m6A 3'UTR//intron       24981863 chr15:61468456-61468457(-) m6A 3'UTR//intron       24981863 chr15:61521276-61521277(-) m6A CDS//exon       27773536 chr15:61521322-61521323(-) m6A CDS//exon       27773536 chr15:61521332-61521333(-) m6A CDS//exon       27773536 chr15:61521418-61521419(-) m6A 5'UTR//exon       27773536

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-616-3p	Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
	RORA	Chromatin K562 cells     - Cytosol HCC cell line (HepG2)     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-616-3p
Interactor2: RORA

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.