Basic Information:

  VIRBase ID:  

HHID00067521

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-616-3p:  MIMAT0004805          PDE8A:  NM_173454     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-616-3p	PDE8A
miRBase Accession/Entrez ID	MIMAT0004805	5151
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	HsT19550

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-616-3p	rs374321661 chr12:57519192    C/T rs573303396 chr12:57519190    A/C rs573303396 chr12:57519190    A/G rs760442491 chr12:57519183    C/T rs763282175 chr12:57519193    C/T rs768469143 chr12:57519184    T/C rs776483081 chr12:57519185    G/A rs368928238 chr12:57519199    A/G rs377525107 chr12:57519198    A/C rs755336783 chr12:57519200    T/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	PDE8A	chr15:85580462(+) A-I      intronic chr15:85621657(+) A-I      intronic chr15:85630129(+) A-I      intronic chr15:85629055(+) A-I      intronic chr15:85604491(+) A-I      intronic chr15:85577046(+) A-I      intronic chr15:85577045(+) A-I      intronic chr15:85621591(+) A-I      intronic chr15:85558527(+) A-I      intronic chr15:85638397(+) A-I      intronic chr15:85605195(+) A-I      intronic chr15:85538774(+) A-I      intronic chr15:85621627(+) A-I      intronic chr15:85621625(+) A-I      intronic chr15:85621621(+) A-I      intronic chr15:85621619(+) A-I      intronic chr15:85678067(+) A-I      intronic chr15:85576818(+) A-I      intronic chr15:85621673(+) A-I      intronic chr15:85621715(+) A-I      intronic chr15:85563615(+) A-I      intronic chr15:85621618(+) A-I      intronic chr15:85580458(+) A-I      intronic chr15:85621648(+) A-I      intronic chr15:85678094(+) A-I      intronic chr15:85621662(+) A-I      intronic chr15:85582205(+) A-I      intronic chr15:85656933(+) A-I      intronic chr15:85562891(+) A-I      intronic chr15:85621666(+) A-I      intronic chr15:85562874(+) A-I      intronic chr15:85580518(+) A-I      intronic chr15:85582143(+) A-I      intronic chr15:85582163(+) A-I      intronic chr15:85582166(+) A-I      intronic chr15:85582167(+) A-I      intronic chr15:85582284(+) A-I      intronic chr15:85582328(+) A-I      intronic chr15:85583416(+) A-I      intronic chr15:85583418(+) A-I      intronic chr15:85583441(+) A-I      intronic chr15:85583933(+) A-I      intronic chr15:85563046(+) A-I      intronic chr15:85630465(+) A-I      intronic chr15:85630534(+) A-I      intronic chr15:85630551(+) A-I      intronic chr15:85630577(+) A-I      intronic chr15:85630599(+) A-I      intronic chr15:85631387(+) A-I      intronic chr15:85631495(+) A-I      intronic chr15:85638598(+) A-I      intronic chr15:85638674(+) A-I      intronic chr15:85638758(+) A-I      intronic chr15:85641936(+) A-I      intronic chr15:85641957(+) A-I      intronic chr15:85641958(+) A-I      intronic chr15:85656990(+) A-I      intronic chr15:85562937(+) A-I      intronic chr15:85562911(+) A-I      intronic chr15:85562910(+) A-I      intronic chr15:85562835(+) A-I      intronic chr15:85561059(+) A-I      intronic chr15:85560965(+) A-I      intronic chr15:85560959(+) A-I      intronic chr15:85560958(+) A-I      intronic chr15:85560934(+) A-I      intronic chr15:85548621(+) A-I      intronic chr15:85548609(+) A-I      intronic chr15:85548586(+) A-I      intronic chr15:85548556(+) A-I      intronic chr15:85548536(+) A-I      intronic chr15:85548475(+) A-I      intronic chr15:85548447(+) A-I      intronic chr15:85540629(+) A-I      intronic chr15:85539982(+) A-I      intronic chr15:85539959(+) A-I      intronic chr15:85539950(+) A-I      intronic chr15:85539680(+) A-I      intronic chr15:85538814(+) A-I      intronic chr15:85538804(+) A-I      intronic chr15:85538790(+) A-I      intronic chr15:85656998(+) A-I      intronic chr15:85674174(+) A-I      intronic chr15:85628753(+) A-I      intronic chr15:85628764(+) A-I      intronic chr15:85548582(+) A-I      intronic chr15:85629019(+) A-I      intronic chr15:85538786(+) A-I      intronic chr15:85538601(+) A-I      intronic chr15:85629096(+) A-I      intronic chr15:85538125(+) A-I      intronic chr15:85538075(+) A-I      intronic chr15:85538048(+) A-I      intronic chr15:85535169(+) A-I      intronic chr15:85535124(+) A-I      intronic chr15:85533341(+) A-I      intronic chr15:85533314(+) A-I      intronic chr15:85530122(+) A-I      intronic chr15:85530098(+) A-I      intronic chr15:85529863(+) A-I      intronic chr15:85529360(+) A-I      intronic chr15:85529311(+) A-I      intronic chr15:85529200(+) A-I      intronic chr15:85539928(+) A-I      intronic chr15:85563597(+) A-I      intronic chr15:85563602(+) A-I      intronic chr15:85562940(+) A-I      intronic chr15:85628722(+) A-I      intronic chr15:85628742(+) A-I      intronic chr15:85629231(+) A-I      intronic chr15:85620134(+) A-I      intronic chr15:85616280(+) A-I      intronic chr15:85616265(+) A-I      intronic chr15:85616111(+) A-I      intronic chr15:85616110(+) A-I      intronic chr15:85563688(+) A-I      intronic chr15:85563724(+) A-I      intronic chr15:85563747(+) A-I      intronic chr15:85563755(+) A-I      intronic chr15:85576886(+) A-I      intronic chr15:85578017(+) A-I      intronic chr15:85630007(+) A-I      intronic chr15:85630013(+) A-I      intronic chr15:85630062(+) A-I      intronic chr15:85630195(+) A-I      intronic chr15:85616082(+) A-I      intronic chr15:85611397(+) A-I      intronic chr15:85611372(+) A-I      intronic chr15:85604545(+) A-I      intronic chr15:85584064(+) A-I      intronic chr15:85584053(+) A-I      intronic chr15:85584052(+) A-I      intronic chr15:85578462(+) A-I      intronic chr15:85580361(+) A-I      intronic chr15:85580476(+) A-I      intronic chr15:85580485(+) A-I      intronic chr15:85629226(+) A-I      intronic chr15:85529942(+) A-I      intronic chr15:85609673(+) A-I      intronic chr15:85583921(+) A-I      intronic chr15:85582461(+) A-I      intronic chr15:85576834(+) A-I      intronic chr15:85639605(+) A-I      intronic chr15:85542990(+) A-I      intronic chr15:85562904(+) A-I      intronic chr15:85639586(+) A-I      intronic chr15:85540537(+) A-I      intronic chr15:85537002(+) A-I      intronic chr15:85629163(+) A-I      intronic chr15:85566058(+) A-I      intronic chr15:85541103(+) A-I      intronic chr15:85639207(+) A-I      intronic chr15:85631305(+) A-I      intronic chr15:85628984(+) A-I      intronic chr15:85603110(+) A-I      intronic chr15:85630178(+) A-I      intronic chr15:85558622(+) A-I      intronic chr15:85578044(+) A-I      intronic chr15:85539685(+) A-I      intronic chr15:85577083(+) A-I      intronic chr15:85639236(+) A-I      intronic chr15:85530059(+) A-I      intronic chr15:85577017(+) A-I      intronic chr15:85628676(+) A-I      intronic chr15:85639677(+) A-I      intronic chr15:85630192(+) A-I      intronic chr15:85539495(+) A-I      intronic chr15:85608015(+) A-I      intronic chr15:85630615(+) A-I      intronic chr15:85529198(+) A-I      intronic chr15:85539998(+) A-I      intronic chr15:85538678(+) A-I      intronic chr15:85577968(+) A-I      intronic chr15:85592896(+) A-I      intronic chr15:85630567(+) A-I      intronic chr15:85630546(+) A-I      intronic chr15:85628808(+) A-I      intronic chr15:85541107(+) A-I      intronic chr15:85582209(+) A-I      intronic chr15:85530772(+) A-I      intronic chr15:85536553(+) A-I      intronic chr15:85609914(+) A-I      intronic chr15:85630598(+) A-I      intronic chr15:85646261(+) A-I      intronic chr15:85639206(+) A-I      intronic chr15:85628983(+) A-I      intronic chr15:85603118(+) A-I      intronic chr15:85548412(+) A-I      intronic chr15:85538138(+) A-I      intronic chr15:85629248(+) A-I      intronic chr15:85539936(+) A-I      intronic chr15:85571515(+) A-I      intronic chr15:85538148(+) A-I      intronic chr15:85539968(+) A-I      intronic chr15:85631350(+) A-I      intronic chr15:85629158(+) A-I      intronic chr15:85538735(+) A-I      intronic chr15:85529246(+) A-I      intronic chr15:85631453(+) A-I      intronic chr15:85601592(+) A-I      intronic chr15:85629128(+) A-I      intronic chr15:85540963(+) A-I      intronic chr15:85639596(+) A-I      intronic chr15:85540965(+) A-I      intronic chr15:85536975(+) A-I      intronic chr15:85629058(+) A-I      intronic chr15:85582293(+) A-I      intronic chr15:85631390(+) A-I      intronic chr15:85638814(+) A-I      intronic chr15:85629091(+) A-I      intronic chr15:85664549(+) A-I      intronic chr15:85630005(+) A-I      intronic chr15:85638606(+) A-I      intronic chr15:85536563(+) A-I      intronic chr15:85538754(+) A-I      intronic chr15:85609906(+) A-I      intronic chr15:85540917(+) A-I      intronic chr15:85576919(+) A-I      intronic chr15:85629092(+) A-I      intronic chr15:85558587(+) A-I      intronic chr15:85642097(+) A-I      intronic chr15:85630086(+) A-I      intronic chr15:85580517(+) A-I      intronic chr15:85638600(+) A-I      intronic chr15:85538787(+) A-I      intronic chr15:85628733(+) A-I      intronic chr15:85611329(+) A-I      intronic chr15:85564517(+) A-I      intronic chr15:85540554(+) A-I      intronic chr15:85628782(+) A-I      intronic chr15:85630621(+) A-I      intronic chr15:85569936(+) A-I      intronic chr15:85529883(+) A-I      intronic chr15:85538615(+) A-I      intronic chr15:85670317(+) A-I      intronic chr15:85639551(+) A-I      intronic chr15:85630457(+) A-I      intronic chr15:85583550(+) A-I      intronic chr15:85631530(+) A-I      intronic chr15:85628743(+) A-I      intronic chr15:85535117(+) A-I      intronic chr15:85636301(+) A-I      intronic chr15:85639951(+) A-I      intronic chr15:85539663(+) A-I      intronic chr15:85630594(+) A-I      intronic chr15:85608098(+) A-I      intronic chr15:85536420(+) A-I      intronic chr15:85628847(+) A-I      intronic chr15:85630107(+) A-I      intronic chr15:85642030(+) A-I      intronic chr15:85563715(+) A-I      intronic chr15:85630537(+) A-I      intronic chr15:85559247(+) A-I      intronic chr15:85629063(+) A-I      intronic chr15:85630653(+) A-I      intronic chr15:85630573(+) A-I      intronic chr15:85639599(+) A-I      intronic chr15:85560997(+) A-I      intronic chr15:85638655(+) A-I      intronic chr15:85629089(+) A-I      intronic chr15:85582399(+) A-I      intronic chr15:85529229(+) A-I      intronic chr15:85537934(+) A-I      intronic chr15:85539920(+) A-I      intronic chr15:85538620(+) A-I      intronic chr15:85563696(+) A-I      intronic chr15:85630175(+) A-I      intronic chr15:85539963(+) A-I      intronic chr15:85629032(+) A-I      intronic chr15:85539937(+) A-I      intronic chr15:85538772(+) A-I      intronic chr15:85637354(+) A-I      intronic chr15:85561007(+) A-I      intronic chr15:85563579(+) A-I      intronic chr15:85678065(+) A-I      intronic chr15:85539673(+) A-I      intronic chr15:85629090(+) A-I      intronic chr15:85539548(+) A-I      intronic chr15:85639917(+) A-I      intronic chr15:85565998(+) A-I      intronic chr15:85576909(+) A-I      intronic chr15:85631436(+) A-I      intronic chr15:85539849(+) A-I      intronic chr15:85628719(+) A-I      intronic chr15:85628730(+) A-I      intronic chr15:85630705(+) A-I      intronic chr15:85559240(+) A-I      intronic chr15:85563714(+) A-I      intronic chr15:85639918(+) A-I      intronic chr15:85629164(+) A-I      intronic chr15:85630563(+) A-I      intronic chr15:85582418(+) A-I      intronic chr15:85629233(+) A-I      intronic chr15:85548410(+) A-I      intronic chr15:85638678(+) A-I      intronic chr15:85601294(+) A-I      intronic chr15:85529862(+) A-I      intronic chr15:85537969(+) A-I      intronic chr15:85536837(+) A-I      intronic chr15:85583534(+) A-I      intronic chr15:85582091(+) A-I      intronic chr15:85636313(+) A-I      intronic chr15:85608191(+) A-I      intronic chr15:85636257(+) A-I      intronic chr15:85537948(+) A-I      intronic chr15:85548624(+) A-I      intronic chr15:85678574(+) A-I      intronic chr15:85639610(+) A-I      intronic chr15:85539674(+) A-I      intronic chr15:85562869(+) A-I      intronic chr15:85631518(+) A-I      intronic chr15:85536599(+) A-I      intronic chr15:85629985(+) A-I      intronic chr15:85563786(+) A-I      intronic chr15:85638679(+) A-I      intronic chr15:85576871(+) A-I      intronic chr15:85548535(+) A-I      intronic chr15:85630606(+) A-I      intronic chr15:85541026(+) A-I      intronic chr15:85630489(+) A-I      intronic chr15:85639211(+) A-I      intronic chr15:85538773(+) A-I      intronic chr15:85539896(+) A-I      intronic chr15:85639575(+) A-I      intronic chr15:85539581(+) A-I      intronic chr15:85539967(+) A-I      intronic chr15:85582297(+) A-I      intronic chr15:85636243(+) A-I      intronic chr15:85629088(+) A-I      intronic chr15:85628802(+) A-I      intronic chr15:85529972(+) A-I      intronic chr15:85630075(+) A-I      intronic chr15:85631439(+) A-I      intronic chr15:85642108(+) A-I      intronic chr15:85538610(+) A-I      intronic chr15:85530133(+) A-I      intronic chr15:85537942(+) A-I      intronic chr15:85539926(+) A-I      intronic chr15:85538688(+) A-I      intronic chr15:85538826(+) A-I      intronic chr15:85539895(+) A-I      intronic chr15:85558532(+) A-I      intronic chr15:85628809(+) A-I      intronic chr15:85539855(+) A-I      intronic chr15:85629149(+) A-I      intronic chr15:85629188(+) A-I      intronic chr15:85548377(+) A-I      intronic chr15:85537039(+) A-I      intronic chr15:85630082(+) A-I      intronic chr15:85539433(+) A-I      intronic chr15:85642031(+) A-I      intronic chr15:85628745(+) A-I      intronic chr15:85536929(+) A-I      intronic chr15:85630666(+) A-I      intronic chr15:85628822(+) A-I      intronic chr15:85565884(+) A-I      intronic chr15:85529239(+) A-I      intronic chr15:85656989(+) A-I      intronic chr15:85540954(+) A-I      intronic chr15:85640029(+) A-I      intronic chr15:85662627(+) A-I      intronic chr15:85563580(+) A-I      intronic chr15:85639187(+) A-I      intronic chr15:85639224(+) A-I      intronic chr15:85630501(+) A-I      intronic chr15:85630232(+) A-I      intronic chr15:85539564(+) A-I      intronic chr15:85639579(+) A-I      intronic chr15:85582393(+) A-I      intronic chr15:85656931(+) A-I      intronic chr15:85583445(+) A-I      intronic chr15:85639948(+) A-I      intronic chr15:85539590(+) A-I      intronic chr15:85641935(+) A-I      intronic chr15:85569944(+) A-I      intronic chr15:85539800(+) A-I      intronic chr15:85638837(+) A-I      intronic chr15:85611389(+) A-I      intronic chr15:85678138(+) A-I      intronic chr15:85638385(+) A-I      intronic chr15:85629093(+) A-I      intronic chr15:85631380(+) A-I      intronic chr15:85630707(+) A-I      intronic chr15:85537064(+) A-I      intronic chr15:85558557(+) A-I      intronic chr15:85541006(+) A-I      intronic chr15:85539521(+) A-I      intronic chr15:85583997(+) A-I      intronic chr15:85657025(+) A-I      intronic chr15:85630121(+) A-I      intronic chr15:85628675(+) A-I      intronic chr15:85611351(+) A-I      intronic chr15:85629040(+) A-I      intronic chr15:85678071(+) A-I      intronic chr15:85548549(+) A-I      intronic chr15:85582232(+) A-I      intronic chr15:85537021(+) A-I      intronic chr15:85678546(+) A-I      intronic chr15:85611451(+) A-I      intronic chr15:85538690(+) A-I      intronic chr15:85630046(+) A-I      intronic chr15:85571681(+) A-I      intronic chr15:85523987(+) A-I      intronic chr15:85529943(+) A-I      intronic chr15:85638311(+) A-I      intronic chr15:85603159(+) A-I      intronic chr15:85583931(+) A-I      intronic chr15:85540927(+) A-I      intronic chr15:85642009(+) A-I      intronic chr15:85639592(+) A-I      intronic chr15:85642171(+) A-I      intronic chr15:85539622(+) A-I      intronic chr15:85537943(+) A-I      intronic chr15:85539854(+) A-I      intronic chr15:85578043(+) A-I      intronic chr15:85681409(+) A-I      3'UTR

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	PDE8A	chr15:85678546(+) A-I intron -    19478186 chr15:85681409(+) A-I exon 3'UTR    19478186 chr15:85539855(+) A-I intron -    22327324 chr15:85628676(+) A-I intron -    22327324 chr15:85639918(+) A-I intron -    21960545   //22327324 chr15:85639579(+) A-I intron -    21960545 chr15:85533353(+) A-I intron -    21960545 chr15:85638311(+) A-I intron -    21960545 chr15:85638379(+) A-I intron -    21960545 chr15:85638397(+) A-I intron -    21960545 chr15:85639950(+) A-I intron -    21960545 chr15:85639951(+) A-I intron -    21960545 chr15:85530133(+) A-G intron -    22484847 chr15:85539855(+) A-G intron -    22484847 chr15:85539963(+) A-G intron -    22484847 chr15:85628675(+) A-G intron -    22484847 chr15:85628676(+) A-G intron -    22484847 chr15:85628743(+) A-G intron -    22484847 chr15:85628782(+) A-G intron -    22484847 chr15:85628809(+) A-G intron -    22484847 chr15:85629149(+) A-G intron -    22484847 chr15:85629158(+) A-G intron -    22484847 chr15:85630567(+) A-G intron -    22484847 chr15:85638606(+) A-G intron -    22484847 chr15:85638678(+) A-G intron -    22484847 chr15:85638679(+) A-G intron -    22484847 chr15:85639579(+) A-G intron -    22484847 chr15:85639592(+) A-G intron -    22484847 chr15:85639605(+) A-G intron -    22484847 chr15:85639610(+) A-G intron -    22484847 chr15:85639918(+) A-G intron -    22484847 chr15:85678065(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	PDE8A	chr15:85523752-85523753(+) m6A 5'UTR//intron       25456834//24981863//22608085 chr15:85523792-85523793(+) m6A 5'UTR//intron       25456834//24981863//22608085 chr15:85523818-85523819(+) m6A 5'UTR//intron       25456834//24981863//22608085 chr15:85523871-85523872(+) m6A 5'UTR//intron       25456834//24981863//22608085 chr15:85634295-85634296(+) m6A 3'UTR//CDS//intron       24981863//26404942 chr15:85641106-85641107(+) m6A exon//intron       24981863 chr15:85641258-85641259(+) m6A 3'UTR//CDS//exon//intron       24981863 chr15:85679873-85679874(+) m6A 3'UTR//CDS//exon       24209618//24981863//26404942 chr15:85681036-85681037(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//26404942 chr15:85681088-85681089(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//26404942//22608085 chr15:85681111-85681112(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//26404942//22608085 chr15:85681140-85681141(+) m6A 3'UTR//exon       24284625//24209618//24981863//26404942//22575960//22608085 chr15:85681232-85681233(+) m6A 3'UTR//exon       24284625//24209618//24981863//26404942//22575960//22608085 chr15:85681271-85681272(+) m6A 3'UTR//exon       24284625//24209618//24981863//26404942//22575960//22608085 chr15:85681322-85681323(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr15:85681378-85681379(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr15:85681406-85681407(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr15:85681445-85681446(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr15:85681479-85681480(+) m6A 3'UTR//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr15:85681579-85681580(+) m6A 3'UTR//exon       24284625//24209618//24981863//27773535//22608085 chr15:85681639-85681640(+) m6A 3'UTR//exon       24284625//24981863//27773535//22608085 chr15:85681794-85681795(+) m6A 3'UTR//exon       27773535 chr15:85682137-85682138(+) m6A 3'UTR//exon       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-616-3p	Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
	PDE8A	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)     - Exosome Blood     - Membrane HCC cell line (HepG2)     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     - Ribosome HEK-293 cells     22199352

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-616-3p
Interactor2: PDE8A

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.