Basic Information:

  VIRBase ID:  

HHID00067512

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-616-3p:  MIMAT0004805          ATP6V1A:  NM_001690     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-616-3p	ATP6V1A
miRBase Accession/Entrez ID	MIMAT0004805	523
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	ARCL2D//ATP6A1//ATP6V1A1//DEE93//HO68//IECEE3//VA68//Vma1//VPP2

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-616-3p	rs374321661 chr12:57519192    C/T rs573303396 chr12:57519190    A/C rs573303396 chr12:57519190    A/G rs760442491 chr12:57519183    C/T rs763282175 chr12:57519193    C/T rs768469143 chr12:57519184    T/C rs776483081 chr12:57519185    G/A rs368928238 chr12:57519199    A/G rs377525107 chr12:57519198    A/C rs755336783 chr12:57519200    T/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	ATP6V1A	chr3:113504517(+) A-I      intronic chr3:113504508(+) A-I      intronic chr3:113504503(+) A-I      intronic chr3:113500233(+) A-I      intronic chr3:113504501(+) A-I      intronic chr3:113504459(+) A-I      intronic chr3:113489373(+) A-I      intronic chr3:113489387(+) A-I      intronic chr3:113500208(+) A-I      intronic chr3:113500211(+) A-I      intronic chr3:113504456(+) A-I      intronic chr3:113500203(+) A-I      intronic chr3:113504468(+) A-I      intronic chr3:113504455(+) A-I      intronic chr3:113484242(+) A-I      intronic chr3:113500199(+) A-I      intronic chr3:113497094(+) A-I      intronic chr3:113497085(+) A-I      intronic chr3:113497080(+) A-I      intronic chr3:113497079(+) A-I      intronic chr3:113494951(+) A-I      intronic chr3:113494950(+) A-I      intronic chr3:113494312(+) A-I      intronic chr3:113493524(+) A-I      intronic chr3:113492046(+) A-I      intronic chr3:113491824(+) A-I      intronic chr3:113490491(+) A-I      intronic chr3:113490466(+) A-I      intronic chr3:113490384(+) A-I      intronic chr3:113489888(+) A-I      intronic chr3:113489784(+) A-I      intronic chr3:113489780(+) A-I      intronic chr3:113489428(+) A-I      intronic chr3:113489376(+) A-I      intronic chr3:113489315(+) A-I      intronic chr3:113489061(+) A-I      intronic chr3:113489021(+) A-I      intronic chr3:113487663(+) A-I      intronic chr3:113487542(+) A-I      intronic chr3:113486722(+) A-I      intronic chr3:113486714(+) A-I      intronic chr3:113486683(+) A-I      intronic chr3:113486674(+) A-I      intronic chr3:113486602(+) A-I      intronic chr3:113485962(+) A-I      intronic chr3:113485380(+) A-I      intronic chr3:113485260(+) A-I      intronic chr3:113485168(+) A-I      intronic chr3:113484699(+) A-I      intronic chr3:113484680(+) A-I      intronic chr3:113484663(+) A-I      intronic chr3:113484654(+) A-I      intronic chr3:113484643(+) A-I      intronic chr3:113484509(+) A-I      intronic chr3:113484291(+) A-I      intronic chr3:113512052(+) A-I      intronic chr3:113519734(+) A-I      intronic chr3:113516809(+) A-I      intronic chr3:113483760(+) A-I      intronic chr3:113483006(+) A-I      intronic chr3:113483000(+) A-I      intronic chr3:113482867(+) A-I      intronic chr3:113482181(+) A-I      intronic chr3:113482173(+) A-I      intronic chr3:113482141(+) A-I      intronic chr3:113482096(+) A-I      intronic chr3:113482080(+) A-I      intronic chr3:113482076(+) A-I      intronic chr3:113482019(+) A-I      intronic chr3:113481295(+) A-I      intronic chr3:113481144(+) A-I      intronic chr3:113516804(+) A-I      intronic chr3:113516332(+) A-I      intronic chr3:113516204(+) A-I      intronic chr3:113515839(+) A-I      intronic chr3:113512090(+) A-I      intronic chr3:113526709(+) A-I      intronic chr3:113509082(+) A-I      intronic chr3:113511958(+) A-I      intronic chr3:113482119(+) A-I      intronic chr3:113526892(+) A-I      intronic chr3:113526870(+) A-I      intronic chr3:113512067(+) A-I      intronic chr3:113512062(+) A-I      intronic chr3:113526862(+) A-I      intronic chr3:113527400(+) A-I      intronic chr3:113526820(+) A-I      intronic chr3:113526801(+) A-I      intronic chr3:113474293(+) A-I      intronic chr3:113504564(+) A-I      intronic chr3:113504495(+) A-I      intronic chr3:113501635(+) A-I      intronic chr3:113526897(+) A-I      intronic chr3:113479984(+) A-I      intronic chr3:113479976(+) A-I      intronic chr3:113479767(+) A-I      intronic chr3:113501564(+) A-I      intronic chr3:113512059(+) A-I      intronic chr3:113479705(+) A-I      intronic chr3:113479704(+) A-I      intronic chr3:113479698(+) A-I      intronic chr3:113508930(+) A-I      intronic chr3:113508921(+) A-I      intronic chr3:113508892(+) A-I      intronic chr3:113508853(+) A-I      intronic chr3:113479388(+) A-I      intronic chr3:113526896(+) A-I      intronic chr3:113501532(+) A-I      intronic chr3:113501494(+) A-I      intronic chr3:113500322(+) A-I      intronic chr3:113500227(+) A-I      intronic chr3:113500217(+) A-I      intronic chr3:113512036(+) A-I      intronic chr3:113528052(+) A-I      intronic chr3:113472682(+) A-I      intronic chr3:113524921(+) A-I      intronic chr3:113524918(+) A-I      intronic chr3:113521695(+) A-I      intronic chr3:113527256(+) A-I      intronic chr3:113527268(+) A-I      intronic chr3:113527321(+) A-I      intronic chr3:113480462(+) A-I      intronic chr3:113480463(+) A-I      intronic chr3:113480486(+) A-I      intronic chr3:113521610(+) A-I      ncRNA chr3:113486039(+) A-I      intronic chr3:113486129(+) A-I      intronic chr3:113491833(+) A-I      intronic chr3:113526120(+) A-I      intronic chr3:113524993(+) A-I      intronic chr3:113489270(+) A-I      intronic chr3:113521397(+) A-I      intronic chr3:113494266(+) A-I      intronic chr3:113480069(+) A-I      intronic chr3:113484361(+) A-I      intronic chr3:113524577(+) A-I      intronic chr3:113508997(+) A-I      intronic chr3:113494298(+) A-I      intronic chr3:113526982(+) A-I      intronic chr3:113491914(+) A-I      intronic chr3:113526966(+) A-I      intronic chr3:113493484(+) A-I      intronic chr3:113519904(+) A-I      intronic chr3:113526929(+) A-I      intronic chr3:113504101(+) A-I      intronic chr3:113484331(+) A-I      intronic chr3:113524964(+) A-I      intronic chr3:113489821(+) A-I      intronic chr3:113515993(+) A-I      intronic chr3:113485217(+) A-I      intronic chr3:113527330(+) A-I      intronic chr3:113495055(+) A-I      intronic chr3:113474380(+) A-I      intronic chr3:113482074(+) A-I      intronic chr3:113493451(+) A-I      intronic chr3:113493462(+) A-I      intronic chr3:113486148(+) A-I      intronic chr3:113495046(+) A-I      intronic chr3:113480359(+) A-I      intronic chr3:113501529(+) A-I      intronic chr3:113489862(+) A-I      intronic chr3:113494177(+) A-I      intronic chr3:113484563(+) A-I      intronic chr3:113516820(+) A-I      intronic chr3:113524555(+) A-I      intronic chr3:113521771(+) A-I      intronic chr3:113494151(+) A-I      intronic chr3:113480050(+) A-I      intronic chr3:113487517(+) A-I      intronic chr3:113516371(+) A-I      intronic chr3:113497121(+) A-I      intronic chr3:113489013(+) A-I      intronic chr3:113504207(+) A-I      intronic chr3:113526816(+) A-I      intronic chr3:113521720(+) A-I      intronic chr3:113509007(+) A-I      intronic chr3:113473274(+) A-I      intronic chr3:113515882(+) A-I      intronic chr3:113489339(+) A-I      intronic chr3:113504040(+) A-I      intronic chr3:113481229(+) A-I      intronic chr3:113474344(+) A-I      intronic chr3:113489405(+) A-I      intronic chr3:113487507(+) A-I      intronic chr3:113497162(+) A-I      intronic chr3:113494357(+) A-I      intronic chr3:113484330(+) A-I      intronic chr3:113493581(+) A-I      intronic chr3:113473269(+) A-I      intronic chr3:113484431(+) A-I      intronic chr3:113516229(+) A-I      intronic chr3:113519849(+) A-I      intronic chr3:113484640(+) A-I      intronic chr3:113482831(+) A-I      intronic chr3:113489778(+) A-I      intronic chr3:113489887(+) A-I      intronic chr3:113486186(+) A-I      intronic chr3:113519844(+) A-I      intronic chr3:113482003(+) A-I      intronic chr3:113479754(+) A-I      intronic chr3:113516833(+) A-I      intronic chr3:113480329(+) A-I      intronic chr3:113519746(+) A-I      intronic chr3:113529163(+) A-I      3'UTR chr3:113485987(+) A-I      intronic chr3:113524840(+) A-I      intronic chr3:113497383(+) A-I      intronic chr3:113483709(+) A-I      intronic chr3:113489269(+) A-I      intronic chr3:113521745(+) A-I      intronic chr3:113486149(+) A-I      intronic chr3:113489310(+) A-I      intronic chr3:113519760(+) A-I      intronic chr3:113496457(+) A-I      intronic chr3:113527361(+) A-I      intronic chr3:113525060(+) A-I      intronic chr3:113485236(+) A-I      intronic chr3:113521356(+) A-I      intronic chr3:113485201(+) A-I      intronic chr3:113494299(+) A-I      intronic chr3:113527910(+) A-I      intronic chr3:113495059(+) A-I      intronic chr3:113489159(+) A-I      intronic chr3:113496466(+) A-I      intronic chr3:113489437(+) A-I      intronic chr3:113486709(+) A-I      intronic chr3:113497345(+) A-I      intronic chr3:113504167(+) A-I      intronic chr3:113500370(+) A-I      intronic chr3:113491987(+) A-I      intronic chr3:113496492(+) A-I      intronic chr3:113500158(+) A-I      intronic chr3:113473327(+) A-I      intronic chr3:113521307(+) A-I      intronic chr3:113516312(+) A-I      intronic chr3:113516760(+) A-I      intronic chr3:113472746(+) A-I      intronic chr3:113497098(+) A-I      intronic chr3:113494216(+) A-I      intronic chr3:113481230(+) A-I      intronic chr3:113519792(+) A-I      intronic chr3:113521396(+) A-I      intronic chr3:113494291(+) A-I      intronic chr3:113493539(+) A-I      intronic chr3:113487572(+) A-I      intronic chr3:113487486(+) A-I      intronic chr3:113485381(+) A-I      intronic chr3:113494324(+) A-I      intronic chr3:113487543(+) A-I      intronic chr3:113497338(+) A-I      intronic chr3:113495172(+) A-I      intronic chr3:113526052(+) A-I      intronic chr3:113481294(+) A-I      intronic chr3:113497031(+) A-I      intronic chr3:113519855(+) A-I      intronic chr3:113482208(+) A-I      intronic chr3:113526167(+) A-I      intronic chr3:113497173(+) A-I      intronic chr3:113496401(+) A-I      intronic chr3:113494181(+) A-I      intronic chr3:113501615(+) A-I      intronic chr3:113519941(+) A-I      intronic chr3:113482927(+) A-I      intronic chr3:113501574(+) A-I      intronic chr3:113496525(+) A-I      intronic chr3:113487626(+) A-I      intronic chr3:113480878(+) A-I      intronic chr3:113474368(+) A-I      intronic chr3:113494339(+) A-I      intronic chr3:113496412(+) A-I      intronic chr3:113479820(+) A-I      intronic chr3:113485416(+) A-I      intronic chr3:113497153(+) A-I      intronic chr3:113482064(+) A-I      intronic chr3:113526046(+) A-I      intronic chr3:113489848(+) A-I      intronic chr3:113489673(+) A-I      intronic chr3:113504616(+) A-I      intronic chr3:113485404(+) A-I      intronic chr3:113486741(+) A-I      intronic chr3:113504183(+) A-I      intronic chr3:113479787(+) A-I      intronic chr3:113486122(+) A-I      intronic chr3:113489403(+) A-I      intronic chr3:113524999(+) A-I      intronic chr3:113481394(+) A-I      intronic chr3:113512172(+) A-I      intronic chr3:113483647(+) A-I      intronic chr3:113495041(+) A-I      intronic chr3:113497189(+) A-I      intronic chr3:113494286(+) A-I      intronic chr3:113479997(+) A-I      intronic chr3:113488970(+) A-I      intronic chr3:113497299(+) A-I      intronic chr3:113497340(+) A-I      intronic chr3:113479365(+) A-I      intronic chr3:113485347(+) A-I      intronic chr3:113504430(+) A-I      intronic chr3:113482982(+) A-I      intronic chr3:113511931(+) A-I      intronic chr3:113494194(+) A-I      intronic chr3:113511981(+) A-I      intronic chr3:113495056(+) A-I      intronic chr3:113482832(+) A-I      intronic chr3:113511986(+) A-I      intronic chr3:113483645(+) A-I      intronic chr3:113485394(+) A-I      intronic chr3:113489791(+) A-I      intronic chr3:113489053(+) A-I      intronic chr3:113489854(+) A-I      intronic chr3:113487584(+) A-I      intronic chr3:113484371(+) A-I      intronic chr3:113497309(+) A-I      intronic chr3:113489035(+) A-I      intronic chr3:113521614(+) A-I      ncRNA

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	ATP6V1A	chr3:113472643(+) A-G intron -    22484847 chr3:113473273(+) A-G intron -    22484847 chr3:113473274(+) A-G intron -    22484847 chr3:113474380(+) A-G intron -    22484847 chr3:113479365(+) A-G intron -    22484847 chr3:113479787(+) A-G intron -    22484847 chr3:113479814(+) G-T intron -    22484847 chr3:113479997(+) A-G intron -    22484847 chr3:113481229(+) A-G intron -    22484847 chr3:113481230(+) A-G intron -    22484847 chr3:113481251(+) A-G intron -    22484847 chr3:113482074(+) A-G intron -    22484847 chr3:113482831(+) A-G intron -    22484847 chr3:113482832(+) A-G intron -    22484847 chr3:113484331(+) A-G intron -    22484847 chr3:113484371(+) A-G intron -    22484847 chr3:113484431(+) A-G intron -    22484847 chr3:113484640(+) A-G intron -    22484847 chr3:113485201(+) A-G intron -    22484847 chr3:113485217(+) A-G intron -    22484847 chr3:113485243(+) A-G intron -    22484847 chr3:113485325(+) A-G intron -    22484847 chr3:113485332(+) A-G intron -    22484847 chr3:113485347(+) A-G intron -    22484847 chr3:113485381(+) A-G intron -    22484847 chr3:113485393(+) T-C intron -    22484847 chr3:113485404(+) A-G intron -    22484847 chr3:113485416(+) A-G intron -    22484847 chr3:113485987(+) A-G intron -    22484847 chr3:113486038(+) A-G intron -    22484847 chr3:113486039(+) A-G intron -    22484847 chr3:113486086(+) A-G intron -    22484847 chr3:113486105(+) A-G intron -    22484847 chr3:113486119(+) A-G intron -    22484847 chr3:113486122(+) A-G intron -    22484847 chr3:113486149(+) A-G intron -    22484847 chr3:113486709(+) A-G intron -    22484847 chr3:113487486(+) A-G intron -    22484847 chr3:113487517(+) A-G intron -    22484847 chr3:113487572(+) A-G intron -    22484847 chr3:113487608(+) A-G intron -    22484847 chr3:113488970(+) A-G intron -    22484847 chr3:113488975(+) A-G intron -    22484847 chr3:113489013(+) A-G intron -    22484847 chr3:113489035(+) A-G intron -    22484847 chr3:113489037(+) A-G intron -    22484847 chr3:113489132(+) A-G intron -    22484847 chr3:113489269(+) A-G intron -    22484847 chr3:113489270(+) A-G intron -    22484847 chr3:113489365(+) A-G intron -    22484847 chr3:113489366(+) A-G intron -    22484847 chr3:113489403(+) A-G intron -    22484847 chr3:113489673(+) A-G intron -    22484847 chr3:113489764(+) A-G intron -    22484847 chr3:113489778(+) A-G intron -    22484847 chr3:113489848(+) A-G intron -    22484847 chr3:113489862(+) A-G intron -    22484847 chr3:113491454(+) A-G intron -    22484847 chr3:113491987(+) A-G intron -    22484847 chr3:113493490(+) A-G intron -    22484847 chr3:113493496(+) A-G intron -    22484847 chr3:113493581(+) A-G intron -    22484847 chr3:113494094(+) G-T intron -    22484847 chr3:113494128(+) A-G intron -    22484847 chr3:113494151(+) A-G intron -    22484847 chr3:113494177(+) A-G intron -    22484847 chr3:113494180(+) A-G intron -    22484847 chr3:113494181(+) A-G intron -    22484847 chr3:113494194(+) A-G intron -    22484847 chr3:113494216(+) A-G intron -    22484847 chr3:113494266(+) A-G intron -    22484847 chr3:113494291(+) A-G intron -    22484847 chr3:113494298(+) A-G intron -    22484847 chr3:113494299(+) A-G intron -    22484847 chr3:113496341(+) A-G intron -    22484847 chr3:113496492(+) A-G intron -    22484847 chr3:113497189(+) A-G intron -    22484847 chr3:113501529(+) A-G intron -    22484847 chr3:113501574(+) A-G intron -    22484847 chr3:113501615(+) A-G intron -    22484847 chr3:113504616(+) A-G intron -    22484847 chr3:113504711(+) C-T intron -    22484847 chr3:113508034(+) A-G intron -    22484847 chr3:113511931(+) A-G intron -    22484847 chr3:113511981(+) A-G intron -    22484847 chr3:113515882(+) A-G intron -    22484847 chr3:113515883(+) A-G intron -    22484847 chr3:113516169(+) A-G intron -    22484847 chr3:113516312(+) A-G intron -    22484847 chr3:113521610(+) A-G intron -    22484847 chr3:113526816(+) A-G intron -    22484847 chr3:113527330(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ATP6V1A	chr3:113529285-113529286(+) m6A 3'UTR       27773535 chr3:113530711-113530712(+) m6A 3'UTR       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-616-3p	Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
	ATP6V1A	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol K562 cells     - Exosome Blood     - Insoluble cytoplasm HCC cell line (HepG2)     - Membrane HCC cell line (HepG2)     - Nucleoplasm K562 cells     - Nucleus K562 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-616-3p
Interactor2: ATP6V1A

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.