Basic Information:

  VIRBase ID:  

HHID00067330

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-590-3p:  MIMAT0004801          HMGCR:  NM_000859     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-590-3p	HMGCR
miRBase Accession/Entrez ID	MIMAT0004801	3156
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	LDLCQ3

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-590-3p	rs1435070247 chr7:74191262    G/T rs1554709913 chr7:74191261    T/C rs1554709916 chr7:74191263    T/C rs1554709918 chr7:74191268    G/A rs555659597 chr7:74191273    T/G rs6971711 chr7:74191269    C/T rs781868890 chr7:74191265    T/C rs781868890 chr7:74191265    T/G rs782545428 chr7:74191272    GTC/G rs782782687 chr7:74191264    A/G rs1554709912 chr7:74191255    AT/A

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	HMGCR	chr5:74642661(+) A-I      intronic chr5:74640611(+) A-I      intronic chr5:74642019(+) A-I      intronic chr5:74641916(+) A-I      intronic chr5:74642824(+) A-I      intronic chr5:74642657(+) A-I      intronic chr5:74642048(+) A-I      intronic chr5:74642022(+) A-I      intronic chr5:74642673(+) A-I      intronic chr5:74642672(+) A-I      intronic chr5:74642765(+) A-I      intronic chr5:74640492(+) A-I      intronic chr5:74642583(+) A-I      intronic chr5:74641864(+) A-I      intronic chr5:74642758(+) A-I      intronic chr5:74642074(+) A-I      intronic chr5:74642668(+) A-I      intronic chr5:74642026(+) A-I      intronic chr5:74652700(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	HMGCR	chr5:74638922(+) T-A intron -    22484847 chr5:74641864(+) A-G intron -    22484847 chr5:74641956(+) A-G intron -    22484847 chr5:74642022(+) A-G intron -    22484847 chr5:74642074(+) A-G intron -    22484847 chr5:74642099(+) A-G intron -    22484847 chr5:74642583(+) A-G intron -    22484847 chr5:74642657(+) A-G intron -    22484847 chr5:74642668(+) A-G intron -    22484847 chr5:74642671(+) A-G intron -    22484847 chr5:74642672(+) A-G intron -    22484847 chr5:74642673(+) A-G intron -    22484847 chr5:74642758(+) A-G intron -    22484847 chr5:74642765(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	HMGCR	chr5:74632276-74632277(+) m6A 5'UTR       24981863 chr5:74632285-74632286(+) m6A 5'UTR       24981863 chr5:74632322-74632323(+) m6A 5'UTR       24981863 chr5:74646738-74646739(+) m6A CDS//exon       27773535 chr5:74646913-74646914(+) m6A CDS//exon       27773535 chr5:74646970-74646971(+) m6A CDS//exon       26404942//27773535 chr5:74646980-74646981(+) m6A CDS//exon       26404942//27773535 chr5:74647005-74647006(+) m6A CDS//exon       26404942//27773535 chr5:74647047-74647048(+) m6A CDS//exon       26404942//27773535 chr5:74647066-74647067(+) m6A CDS//exon       26404942//27773535 chr5:74655884-74655885(+) m6A CDS//exon       24284625//24209618//22608085 chr5:74655931-74655932(+) m6A CDS//exon       24284625//24209618//24981863//27773535//22608085 chr5:74656132-74656133(+) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//22608085 chr5:74656158-74656159(+) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//22608085 chr5:74656185-74656186(+) m6A 3'UTR//exon       24284625//24209618//24981863//26404942//27773535//22608085 chr5:74656191-74656192(+) m6A 3'UTR//exon       24284625//24209618//24981863//26404942//27773535//22608085 chr5:74656214-74656215(+) m6A 3'UTR//exon       24284625//24209618//24981863//26404942//27773535//22608085 chr5:74656288-74656289(+) m6A 3'UTR//exon       24284625//24209618//24981863//26404942//22608085 chr5:74656342-74656343(+) m6A 3'UTR//exon       24284625//24981863//26404942//22608085 chr5:74656357-74656358(+) m6A 3'UTR       22608085 chr5:74656627-74656628(+) m6A 3'UTR       27773535 chr5:74656738-74656739(+) m6A 3'UTR       27773535 chr5:74656761-74656762(+) m6A 3'UTR       27773535 chr5:74657456-74657457(+) Y 3'UTR       26075521

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-590-3p	Exosome Plasma     24683445 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
	HMGCR	Chromatin K562 cells     - Cytosol HCC cell line (HepG2)|K562 cells     - Exosome Blood     - Insoluble cytoplasm HCC cell line (HepG2)     - Membrane K562 cells     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus Colon cancer cells     24393600 Nucleus HCC cell line (HepG2)|HeLa-S3 cells     - Ribosome HEK-293 cells     22199352

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-590-3p
Interactor2: HMGCR

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.