Detail Information

Basic Information:


  VIRBase ID:  

HHID00067255

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-589-5p:           BSG:      

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Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-589-5p BSG
miRBase
Accession/Entrez ID		 MIMAT0004799 682
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - 5F7//CD147//EMMPRIN//EMPRIN//HAb18G//OK//SLC7A11//TCSF

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-589-5p
rs1056363013 chr7:5495894    A/G
rs1163876092 chr7:5495879    G/A
rs1164060815 chr7:5495885    G/A
rs1478020289 chr7:5495877    G/C
rs546599623 chr7:5495873    C/A
rs756015449 chr7:5495882    G/A
rs771492695 chr7:5495884    C/T
rs1371869633 chr7:5495888    G/A
rs779889450 chr7:5495893    C/A
rs905150966 chr7:5495887    G/C
rs939253091 chr7:5495892    T/C

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR BSG
chr19:572192(+) A-I      intronic
chr19:574162(+) A-I      intronic
chr19:576506(+) A-I      intronic
chr19:576564(+) A-I      intronic
chr19:576595(+) A-I      intronic
chr19:576598(+) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED BSG
chr19:583488(+) C-A intron -    21725310

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase BSG
chr19:571454-571455(+) m6A 5'UTR       24981863
chr19:571517-571518(+) m6A 5'UTR       24981863
chr19:572614-572615(+) m6A 5'UTR//exon//intron       24284625//25456834//24981863//26404942//22575960
chr19:575063-575064(+) m6A 5'UTR//exon//intron       24284625//25456834//24981863//26404942//22575960
chr19:575233-575234(+) m6A 5'UTR//intron       24284625
chr19:579526-579527(+) m6A 5'UTR//CDS//exon//intron       24284625//26404942//22575960
chr19:579735-579736(+) m6A exon//intron       24284625
chr19:579742-579743(+) m6A exon//intron       24284625
chr19:580383-580384(+) m6A 5'UTR//CDS//exon//intron       24284625//22575960
chr19:580570-580571(+) m6A exon//intron       24284625
chr19:580679-580680(+) m6A CDS//exon//intron       24284625//26404942
chr19:580758-580759(+) Am CDS//exon//intron       -
chr19:580777-580778(+) m6A CDS//exon//intron       24284625//26404942//22575960
chr19:581387-581388(+) m6A CDS//exon//intron       24284625//26404942//22575960
chr19:581393-581394(+) m6A CDS//exon//intron       24284625//26404942//22575960
chr19:582566-582567(+) m6A 3'UTR//CDS//exon       24284625//26404942//22575960
chr19:582843-582844(+) m6A 3'UTR//exon       24284625//26404942
chr19:583238-583239(+) m6A 3'UTR//exon       24284625//25456834//24981863//26404942//27773535//22575960
chr19:583345-583346(+) m6A 3'UTR//exon       24284625//25456834//24981863//27773535//22575960
chr19:583363-583364(+) m6A 3'UTR//exon       24284625//25456834//24981863//27773535//22575960
chr19:583371-583372(+) m6A 3'UTR//exon       24284625//25456834//27773535//22575960
chr19:583441-583442(+) m6A 3'UTR//exon       24284625//27773535

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-589-5p
Exosome Plasma     23663360
Exosome Endothelial cells|Kidney tissue     -
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
Mitochondrion Cell line (HEK-293|HeLa)     22984580
BSG
Chromatin K562 cells     -
Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleolus K562 cells     -
Nucleus Nasopharyngeal carcinoma cells     20498841
Nucleus Nasopharyngeal carcinoma cells     20498841
Nucleus HeLa-S3 cells|K562 cells     -
Ribosome Colon cancer cells     24393600

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-589-5p
Gemcitabine 60750 Drug interaction    RC00007198
Paclitaxel 36314 Drug interaction    RC00007197
Doxorubicin 31703 Drug interaction    RC00007196
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00007195
Verapamil 2520 Drug interaction    RC00007194
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-589-5p
Sunitinib 5329102       31063487
Doxorubicin 31703       29196128

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-589-5p
Interactor2: BSG

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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