Detail Information

Basic Information:


  VIRBase ID:  

HHID00067233

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-576-3p:           MZT1:      

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Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-576-3p MZT1
miRBase
Accession/Entrez ID		 MIMAT0004796 440145
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - C13orf37//MOZART1

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-576-3p
rs1186952823 chr4:109488766    T/C
rs1472315985 chr4:109488773    C/T
rs71603032 chr4:109488767    T/G
rs910619778 chr4:109488769    G/A
rs1286950821 chr4:109488755    A/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR MZT1
chr13:73299074(-) A-I      intronic
chr13:73290177(-) A-I      intronic
chr13:73299141(-) A-I      intronic
chr13:73299078(-) A-I      intronic
chr13:73298749(-) A-I      intronic
chr13:73292889(-) A-I      intronic
chr13:73292896(-) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase MZT1
chr13:73283631-73283632(-) m6A 3'UTR       27773535
chr13:73283638-73283639(-) m6A 3'UTR       27773535
chr13:73283784-73283785(-) m6A 3'UTR       27773535
chr13:73283794-73283795(-) m6A 3'UTR       27773535
chr13:73301670-73301671(-) m6A CDS       24209618

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-576-3p
Exosome Plasma     23663360
Exosome Colon cancer cell line (LIM1863)     25330373
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
MZT1
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol K562 cells     -
Exosome Blood     -
Ribosome Colon cancer cells     24393600

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-576-3p
D-Glucose 5793 Drug interaction    RC00007190
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-576-3p
Cisplatin 5702198       21575166
Doxorubicin 31703       25451164

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-576-3p
Interactor2: MZT1

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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