Detail Information

Basic Information:


  VIRBase ID:  

HHID00067172

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-574-5p:           SNX19:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-574-5p SNX19
miRBase
Accession/Entrez ID		 MIMAT0004795 399979
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - CHET8

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-574-5p
rs1015543190 chr4:38868068    TGTGA/T
rs1253726804 chr4:38868072    AGT/A
rs1302821141 chr4:38868064    T/G
rs1309447183 chr4:38868072    A/T
rs1375708593 chr4:38868074    T/A
rs1392694220 chr4:38868070    TGA/T
rs1226184937 chr4:38868060    T/C
rs1226184937 chr4:38868060    T/G
rs1370445145 chr4:38868052    CGTGTGAGTGTGTGT/C
rs147472159 chr4:38868058    AGT/AGTGT
rs147472159 chr4:38868058    AGT/A
rs769560740 chr4:38868054    TGTGA/T
rs928194144 chr4:38868058    A/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR SNX19
chr11:130754684(-) A-I      intronic
chr11:130761910(-) A-I      intronic
chr11:130761846(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED SNX19
chr11:130751481(-) A-I intron -    21960545

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase SNX19
chr11:130746346-130746347(-) m6A 3'UTR       27773535
chr11:130746410-130746411(-) m6A 3'UTR       27773535
chr11:130747206-130747207(-) Tm 3'UTR       -
chr11:130747344-130747345(-) m6A 3'UTR       24981863
chr11:130747394-130747395(-) m6A 3'UTR       24981863//27773535
chr11:130747484-130747485(-) m6A 3'UTR       27773535
chr11:130747650-130747651(-) m6A 3'UTR       24284625//25456834//24981863//27773535
chr11:130747747-130747748(-) m6A 3'UTR//exon       24284625//25456834//24981863//27773535//27371828
chr11:130747815-130747816(-) m6A 3'UTR//exon       24284625//25456834//24981863//27773535//27371828
chr11:130747820-130747821(-) m6A 3'UTR//exon       24284625//25456834//24981863//27773535//27371828
chr11:130747851-130747852(-) m6A 3'UTR//exon       24284625//25456834//24981863//27773535//27371828//22608085
chr11:130747884-130747885(-) m6A 3'UTR//exon       24284625//24981863//27773535//27371828//22608085
chr11:130747913-130747914(-) m6A 3'UTR//exon       24284625//24981863//27773535//27371828//22608085
chr11:130747924-130747925(-) m6A 3'UTR//exon       24284625//24981863//27773535//27371828//22608085
chr11:130748029-130748030(-) m6A 3'UTR//exon       24284625
chr11:130750953-130750954(-) m6A exon//intron       -
chr11:130762855-130762856(-) m6A exon//intron       27773535
chr11:130775634-130775635(-) m6A 3'UTR//intron       24981863
chr11:130775645-130775646(-) m6A 3'UTR//intron       24981863
chr11:130775867-130775868(-) m6A CDS//exon       24981863
chr11:130775903-130775904(-) m6A CDS//exon       24981863//27773535
chr11:130775926-130775927(-) m6A CDS//exon       27773535
chr11:130775980-130775981(-) m6A CDS//exon//intron       27773535
chr11:130776018-130776019(-) m6A 5'UTR//CDS//exon//intron       27773535
chr11:130776553-130776554(-) m6A 5'UTR//CDS//exon       27773535
chr11:130777887-130777888(-) m6A 5'UTR//CDS//exon//intron       27773535
chr11:130777924-130777925(-) m6A 5'UTR//CDS//exon//intron       27773535
chr11:130777944-130777945(-) m6A 5'UTR//CDS//exon//intron       27773535
chr11:130777955-130777956(-) m6A 5'UTR//CDS//exon//intron       27773535
chr11:130781640-130781641(-) m6A 5'UTR//CDS//exon       24981863//27773535
chr11:130781659-130781660(-) m6A 5'UTR//CDS//exon       24981863//27773535
chr11:130784239-130784240(-) m6A CDS//intron       24284625//24981863//27773535
chr11:130784411-130784412(-) m6A CDS//intron       24284625//24209618//24981863//27773535//27371828//22575960
chr11:130784463-130784464(-) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr11:130784476-130784477(-) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr11:130784534-130784535(-) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr11:130784540-130784541(-) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr11:130784546-130784547(-) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr11:130784598-130784599(-) m6A 5'UTR//CDS//intron       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr11:130784684-130784685(-) m6A CDS//intron       24284625//25456834//24981863//27371828//27773536//22575960//22608085
chr11:130784697-130784698(-) m6A CDS//intron       24284625//25456834//24981863//27371828//27773536
chr11:130784725-130784726(-) m6A CDS//intron       24284625//24981863
chr11:130784782-130784783(-) m6A CDS//intron       24284625//24981863
chr11:130784985-130784986(-) m6A CDS//intron       24284625//24209618//24981863//27773535//27371828//22575960
chr11:130785114-130785115(-) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr11:130785143-130785144(-) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr11:130785385-130785386(-) m6A CDS//intron       24284625//24209618//25456834//24981863//27371828//27773536//22575960//22608085
chr11:130785800-130785801(-) m6A CDS//intron       24284625
chr11:130785821-130785822(-) m6A CDS//intron       24284625
chr11:130785827-130785828(-) m6A CDS//intron       24284625
chr11:130785916-130785917(-) m6A 5'UTR//intron       24284625//24981863//27371828//22575960
chr11:130785944-130785945(-) m6A 5'UTR//intron       24284625//24981863//27371828//22575960
chr11:130785975-130785976(-) m6A 5'UTR//intron       24284625//24981863//27371828//22575960
chr11:130786269-130786270(-) m6A 5'UTR//exon       24981863//27371828//27773536

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-574-5p
Exosome Breast cancer cell line (MCF-7)     20976003
Exosome Breast milk     22211110
Exosome Plasma     23663360
Exosome Human mast cell line (HMC-1)     24009880
Exosome Breast milk|Seminal fluid     -
Extracellular vesicle Colon cancer cell line (LIM1863)     25330373
Microvesicle Seminal plasma     23539611
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
Mitochondrion Cell line (HEK-293|HeLa)     22984580
Nucleus LAC cell line (A549)     32231562
SNX19
Chromatin K562 cells     -
Cytosol K562 cells     -
Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Ribosome Colon cancer cells     24393600

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-574-5p
MMP-9/MMP-13 Inhibitor I 9983251 Drug resistant
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-574-5p
5-Fluorouracil 3385 Drug interaction    RC00007188
Ginsenoside Rh2 119307 Drug interaction    RC00007189
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-574-5p
Imatinib 5291       25349971
Resource Symbol Drug Name PubChem ID
RNAactDrug hsa-miR-574-5p
Panobinostat       6918837
Irinotecan       60838
Topotecan       60700
l-685,458       5479543
Palbociclib       5330286
Paclitaxel       36314
Sorafenib       216239
5-Chloro-N4-(2-(isopropylsulfonyl)phenyl)-N2-(2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)pyrimidine-2,4-diamine       16038120
Dovitinib       135398510
Crizotinib       11626560
Pha-665752       10461815

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-574-5p
Interactor2: SNX19

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region CDS
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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