Detail Information

Basic Information:


  VIRBase ID:  

HHID00067164

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-574-5p:           ANKRD40:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-574-5p ANKRD40
miRBase
Accession/Entrez ID		 MIMAT0004795 91369
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - -

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-574-5p
rs1015543190 chr4:38868068    TGTGA/T
rs1253726804 chr4:38868072    AGT/A
rs1302821141 chr4:38868064    T/G
rs1309447183 chr4:38868072    A/T
rs1375708593 chr4:38868074    T/A
rs1392694220 chr4:38868070    TGA/T
rs1226184937 chr4:38868060    T/C
rs1226184937 chr4:38868060    T/G
rs1370445145 chr4:38868052    CGTGTGAGTGTGTGT/C
rs147472159 chr4:38868058    AGT/AGTGT
rs147472159 chr4:38868058    AGT/A
rs769560740 chr4:38868054    TGTGA/T
rs928194144 chr4:38868058    A/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR ANKRD40
chr17:48771274(-) A-I      3'UTR
chr17:48784125(-) A-I      intronic
chr17:48783098(-) A-I      intronic
chr17:48771266(-) A-I      3'UTR
chr17:48783512(-) A-I      intronic
chr17:48771247(-) A-I      3'UTR
chr17:48771248(-) A-I      3'UTR
chr17:48783130(-) A-I      intronic
chr17:48783189(-) A-I      intronic
chr17:48783190(-) A-I      intronic
chr17:48783192(-) A-I      intronic
chr17:48771249(-) A-I      3'UTR
chr17:48784153(-) A-I      intronic
chr17:48781764(-) A-I      intronic
chr17:48782308(-) A-I      intronic
chr17:48782311(-) A-I      intronic
chr17:48782326(-) A-I      intronic
chr17:48782340(-) A-I      intronic
chr17:48782353(-) A-I      intronic
chr17:48782363(-) A-I      intronic
chr17:48782388(-) A-I      intronic
chr17:48783665(-) A-I      intronic
chr17:48783681(-) A-I      intronic
chr17:48783702(-) A-I      intronic
chr17:48783731(-) A-I      intronic
chr17:48784018(-) A-I      intronic
chr17:48784045(-) A-I      intronic
chr17:48783133(-) A-I      intronic
chr17:48783128(-) A-I      intronic
chr17:48784167(-) A-I      intronic
chr17:48783594(-) A-I      intronic
chr17:48783611(-) A-I      intronic
chr17:48781619(-) A-I      intronic
chr17:48783621(-) A-I      intronic
chr17:48783647(-) A-I      intronic
chr17:48783656(-) A-I      intronic
chr17:48783660(-) A-I      intronic
chr17:48783662(-) A-I      intronic
chr17:48783271(-) A-I      intronic
chr17:48783516(-) A-I      intronic
chr17:48783556(-) A-I      intronic
chr17:48784143(-) A-I      intronic
chr17:48783090(-) A-I      intronic
chr17:48783089(-) A-I      intronic
chr17:48783154(-) A-I      intronic
chr17:48783195(-) A-I      intronic
chr17:48783186(-) A-I      intronic
chr17:48781863(-) A-I      intronic
chr17:48781761(-) A-I      intronic
chr17:48783238(-) A-I      intronic
chr17:48783159(-) A-I      intronic
chr17:48779581(-) A-I      intronic
chr17:48783127(-) A-I      intronic
chr17:48783580(-) A-I      intronic
chr17:48783191(-) A-I      intronic
chr17:48781631(-) A-I      intronic
chr17:48784060(-) A-I      intronic
chr17:48783136(-) A-I      intronic
chr17:48783050(-) A-I      intronic
chr17:48783257(-) A-I      intronic
chr17:48783115(-) A-I      intronic
chr17:48783150(-) A-I      intronic
chr17:48783199(-) A-I      intronic
chr17:48783715(-) A-I      intronic
chr17:48781837(-) A-I      intronic
chr17:48784028(-) A-I      intronic
chr17:48783118(-) A-I      intronic
chr17:48784183(-) A-I      intronic
chr17:48777722(-) A-I      intronic
chr17:48783301(-) A-I      intronic
chr17:48783262(-) A-I      intronic
chr17:48782232(-) A-I      intronic
chr17:48783182(-) A-I      intronic
chr17:48783293(-) A-I      intronic
chr17:48783200(-) A-I      intronic
chr17:48782219(-) A-I      intronic
chr17:48783056(-) A-I      intronic
chr17:48784202(-) A-I      intronic
chr17:48781688(-) A-I      intronic
chr17:48783240(-) A-I      intronic
chr17:48783505(-) A-I      intronic
chr17:48783292(-) A-I      intronic
chr17:48783225(-) A-I      intronic
chr17:48782909(-) A-I      intronic
chr17:48783119(-) A-I      intronic
chr17:48783124(-) A-I      intronic
chr17:48783176(-) A-I      intronic
chr17:48784208(-) A-I      intronic
chr17:48783097(-) A-I      intronic
chr17:48783204(-) A-I      intronic
chr17:48783226(-) A-I      intronic
chr17:48783579(-) A-I      intronic
chr17:48777721(-) A-I      intronic
chr17:48783215(-) A-I      intronic
chr17:48782983(-) A-I      intronic
chr17:48782206(-) A-I      intronic
chr17:48783249(-) A-I      intronic
chr17:48783629(-) A-I      intronic
chr17:48781794(-) A-I      intronic
chr17:48783201(-) A-I      intronic
chr17:48782231(-) A-I      intronic
chr17:48782982(-) A-I      intronic
chr17:48782158(-) A-I      intronic
chr17:48783094(-) A-I      intronic
chr17:48782286(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED ANKRD40
chr17:48783089(-) A-I intron -    22028664
chr17:48783090(-) A-I intron -    22028664
chr17:48783097(-) A-I intron -    22028664
chr17:48783115(-) A-I intron -    22028664
chr17:48783136(-) A-I intron -    22028664
chr17:48783154(-) A-I intron -    22028664
chr17:48783159(-) A-I intron -    22028664
chr17:48783176(-) A-I intron -    22028664
chr17:48783182(-) A-I intron -    22028664
chr17:48783186(-) A-I intron -    22028664
chr17:48783191(-) A-I intron -    22028664
chr17:48783195(-) A-I intron -    22028664
chr17:48783199(-) A-I intron -    22028664
chr17:48783201(-) A-I intron -    22028664
chr17:48783204(-) A-I intron -    22028664
chr17:48783215(-) A-I intron -    22028664
chr17:48783225(-) A-I intron -    22028664
chr17:48783226(-) A-I intron -    22028664
chr17:48783238(-) A-I intron -    22028664
chr17:48783249(-) A-I intron -    22028664
chr17:48783257(-) A-I intron -    22028664
chr17:48783262(-) A-I intron -    22028664
chr17:48783292(-) A-I intron -    22028664
chr17:48781863(-) A-G intron -    22484847
chr17:48782231(-) A-G intron -    22484847
chr17:48782232(-) A-G intron -    22484847
chr17:48782286(-) A-G intron -    22484847
chr17:48783118(-) A-G intron -    22484847
chr17:48783176(-) A-G intron -    22484847
chr17:48783199(-) A-G intron -    22484847
chr17:48783200(-) A-G intron -    22484847
chr17:48783579(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase ANKRD40
chr17:48770786-48770787(-) Y 3'UTR       26075521
chr17:48771286-48771287(-) m6A 3'UTR       24209618
chr17:48771321-48771322(-) m6A 3'UTR       24209618
chr17:48772560-48772561(-) m6A 3'UTR       27773535
chr17:48772607-48772608(-) m6A 3'UTR       27773535
chr17:48772696-48772697(-) m6A 3'UTR       24284625//27773535//22608085
chr17:48772850-48772851(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr17:48772888-48772889(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr17:48772911-48772912(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr17:48772928-48772929(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr17:48773130-48773131(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr17:48773151-48773152(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr17:48773297-48773298(-) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr17:48773346-48773347(-) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr17:48773369-48773370(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr17:48773462-48773463(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr17:48776925-48776926(-) m6A CDS       24284625//27773535
chr17:48776942-48776943(-) m6A CDS       24284625//27773535
chr17:48777004-48777005(-) m6A CDS       24284625//27773535
chr17:48777017-48777018(-) m6A CDS       24284625//27773535
chr17:48777033-48777034(-) m6A CDS       24284625//27773535
chr17:48777189-48777190(-) m6A CDS       24981863//26404942//27773535
chr17:48777200-48777201(-) m1A CDS       26863196
chr17:48777247-48777248(-) m1A CDS       26863196
chr17:48777907-48777908(-) m6A exon//intron       24981863
chr17:48778021-48778022(-) Y 5'UTR//CDS//exon       26075521
chr17:48778047-48778048(-) m6A 5'UTR//CDS//exon       24209618//24981863//27773535
chr17:48778075-48778076(-) m6A 5'UTR//CDS//exon       24209618//24981863//27773535
chr17:48778174-48778175(-) m6A 5'UTR//intron       24209618
chr17:48784905-48784906(-) m6A CDS//exon       24209618//24981863
chr17:48784931-48784932(-) m6A CDS//exon       24209618//24981863
chr17:48784950-48784951(-) m6A CDS//exon       24209618//24981863
chr17:48785272-48785273(-) m6A 5'UTR       24981863//27773536

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-574-5p
Exosome Breast cancer cell line (MCF-7)     20976003
Exosome Breast milk     22211110
Exosome Plasma     23663360
Exosome Human mast cell line (HMC-1)     24009880
Exosome Breast milk|Seminal fluid     -
Extracellular vesicle Colon cancer cell line (LIM1863)     25330373
Microvesicle Seminal plasma     23539611
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
Mitochondrion Cell line (HEK-293|HeLa)     22984580
Nucleus LAC cell line (A549)     32231562
ANKRD40
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Membrane HCC cell line (HepG2)     -
Nucleoplasm K562 cells     -
Ribosome Colon cancer cells     24393600

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-574-5p
MMP-9/MMP-13 Inhibitor I 9983251 Drug resistant
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-574-5p
5-Fluorouracil 3385 Drug interaction    RC00007188
Ginsenoside Rh2 119307 Drug interaction    RC00007189
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-574-5p
Imatinib 5291       25349971
Resource Symbol Drug Name PubChem ID
RNAactDrug hsa-miR-574-5p
Panobinostat       6918837
Irinotecan       60838
Topotecan       60700
l-685,458       5479543
Palbociclib       5330286
Paclitaxel       36314
Sorafenib       216239
5-Chloro-N4-(2-(isopropylsulfonyl)phenyl)-N2-(2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)pyrimidine-2,4-diamine       16038120
Dovitinib       135398510
Crizotinib       11626560
Pha-665752       10461815

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-574-5p
Interactor2: ANKRD40

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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