Detail Information

Basic Information:


  VIRBase ID:  

HHID00067158

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-574-5p:           NARS2:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-574-5p NARS2
miRBase
Accession/Entrez ID		 MIMAT0004795 79731
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - asnRS//DFNB94//SLM5

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-574-5p
rs1015543190 chr4:38868068    TGTGA/T
rs1253726804 chr4:38868072    AGT/A
rs1302821141 chr4:38868064    T/G
rs1309447183 chr4:38868072    A/T
rs1375708593 chr4:38868074    T/A
rs1392694220 chr4:38868070    TGA/T
rs1226184937 chr4:38868060    T/C
rs1226184937 chr4:38868060    T/G
rs1370445145 chr4:38868052    CGTGTGAGTGTGTGT/C
rs147472159 chr4:38868058    AGT/AGTGT
rs147472159 chr4:38868058    AGT/A
rs769560740 chr4:38868054    TGTGA/T
rs928194144 chr4:38868058    A/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR NARS2
chr11:78222574(-) A-I      intronic
chr11:78162645(-) A-I      intronic
chr11:78172877(-) A-I      intronic
chr11:78174373(-) A-I      intronic
chr11:78174348(-) A-I      intronic
chr11:78174319(-) A-I      intronic
chr11:78148945(-) A-I      intronic
chr11:78148939(-) A-I      intronic
chr11:78150258(-) A-I      intronic
chr11:78150264(-) A-I      intronic
chr11:78172912(-) A-I      intronic
chr11:78211612(-) A-I      intronic
chr11:78200984(-) A-I      intronic
chr11:78156419(-) A-I      intronic
chr11:78148793(-) A-I      intronic
chr11:78197059(-) A-I      intronic
chr11:78191069(-) A-I      intronic
chr11:78150180(-) A-I      intronic
chr11:78156402(-) A-I      intronic
chr11:78190460(-) A-I      intronic
chr11:78186890(-) A-I      intronic
chr11:78186887(-) A-I      intronic
chr11:78186884(-) A-I      intronic
chr11:78184129(-) A-I      intronic
chr11:78177699(-) A-I      intronic
chr11:78152713(-) A-I      intronic
chr11:78177697(-) A-I      intronic
chr11:78174649(-) A-I      intronic
chr11:78232265(-) A-I      intronic
chr11:78204463(-) A-I      intronic
chr11:78174329(-) A-I      intronic
chr11:78174279(-) A-I      intronic
chr11:78174277(-) A-I      intronic
chr11:78152674(-) A-I      intronic
chr11:78200975(-) A-I      intronic
chr11:78156924(-) A-I      intronic
chr11:78174254(-) A-I      intronic
chr11:78174235(-) A-I      intronic
chr11:78179014(-) A-I      intronic
chr11:78170242(-) A-I      intronic
chr11:78170079(-) A-I      intronic
chr11:78169966(-) A-I      intronic
chr11:78152671(-) A-I      intronic
chr11:78151684(-) A-I      intronic
chr11:78165848(-) A-I      intronic
chr11:78165793(-) A-I      intronic
chr11:78165775(-) A-I      intronic
chr11:78217851(-) A-I      intronic
chr11:78150152(-) A-I      intronic
chr11:78155602(-) A-I      intronic
chr11:78201083(-) A-I      intronic
chr11:78151238(-) A-I      intronic
chr11:78149012(-) A-I      intronic
chr11:78149007(-) A-I      intronic
chr11:78151188(-) A-I      intronic
chr11:78151185(-) A-I      intronic
chr11:78170099(-) A-I      intronic
chr11:78148934(-) A-I      intronic
chr11:78148921(-) A-I      intronic
chr11:78222507(-) A-I      intronic
chr11:78222404(-) A-I      intronic
chr11:78218838(-) A-I      intronic
chr11:78196950(-) A-I      intronic
chr11:78178391(-) A-I      intronic
chr11:78200946(-) A-I      intronic
chr11:78148909(-) A-I      intronic
chr11:78177806(-) A-I      intronic
chr11:78148938(-) A-I      intronic
chr11:78232004(-) A-I      intronic
chr11:78156437(-) A-I      intronic
chr11:78150195(-) A-I      intronic
chr11:78170056(-) A-I      intronic
chr11:78148770(-) A-I      intronic
chr11:78174620(-) A-I      intronic
chr11:78150281(-) A-I      intronic
chr11:78174302(-) A-I      intronic
chr11:78170025(-) A-I      intronic
chr11:78225307(-) A-I      intronic
chr11:78212026(-) A-I      intronic
chr11:78212102(-) A-I      intronic
chr11:78213793(-) A-I      intronic
chr11:78213954(-) A-I      intronic
chr11:78213957(-) A-I      intronic
chr11:78213983(-) A-I      intronic
chr11:78174264(-) A-I      intronic
chr11:78231964(-) A-I      intronic
chr11:78211572(-) A-I      intronic
chr11:78214397(-) A-I      intronic
chr11:78214399(-) A-I      intronic
chr11:78204688(-) A-I      intronic
chr11:78214454(-) A-I      intronic
chr11:78191221(-) A-I      intronic
chr11:78214463(-) A-I      intronic
chr11:78216209(-) A-I      intronic
chr11:78218726(-) A-I      intronic
chr11:78218736(-) A-I      intronic
chr11:78218744(-) A-I      intronic
chr11:78148778(-) A-I      intronic
chr11:78280999(-) A-I      intronic
chr11:78222291(-) A-I      intronic
chr11:78222292(-) A-I      intronic
chr11:78222304(-) A-I      intronic
chr11:78222328(-) A-I      intronic
chr11:78222195(-) A-I      intronic
chr11:78214556(-) A-I      intronic
chr11:78222352(-) A-I      intronic
chr11:78222706(-) A-I      intronic
chr11:78224632(-) A-I      intronic
chr11:78224658(-) A-I      intronic
chr11:78224716(-) A-I      intronic
chr11:78224724(-) A-I      intronic
chr11:78231018(-) A-I      intronic
chr11:78231839(-) A-I      intronic
chr11:78232499(-) A-I      intronic
chr11:78214459(-) A-I      intronic
chr11:78233276(-) A-I      intronic
chr11:78233295(-) A-I      intronic
chr11:78252165(-) A-I      intronic
chr11:78255939(-) A-I      intronic
chr11:78255943(-) A-I      intronic
chr11:78274335(-) A-I      intronic
chr11:78274644(-) A-I      intronic
chr11:78274711(-) A-I      intronic
chr11:78274737(-) A-I      intronic
chr11:78274742(-) A-I      intronic
chr11:78201079(-) A-I      intronic
chr11:78274863(-) A-I      intronic
chr11:78280977(-) A-I      intronic
chr11:78280990(-) A-I      intronic
chr11:78149015(-) A-I      intronic
chr11:78211696(-) A-I      intronic
chr11:78190991(-) A-I      intronic
chr11:78275083(-) A-I      intronic
chr11:78200976(-) A-I      intronic
chr11:78156422(-) A-I      intronic
chr11:78233236(-) A-I      intronic
chr11:78232321(-) A-I      intronic
chr11:78155550(-) A-I      intronic
chr11:78191218(-) A-I      intronic
chr11:78220021(-) A-I      intronic
chr11:78216293(-) A-I      intronic
chr11:78224748(-) A-I      intronic
chr11:78211684(-) A-I      intronic
chr11:78222288(-) A-I      intronic
chr11:78174234(-) A-I      intronic
chr11:78217879(-) A-I      intronic
chr11:78148766(-) A-I      intronic
chr11:78184125(-) A-I      intronic
chr11:78148872(-) A-I      intronic
chr11:78201001(-) A-I      intronic
chr11:78148899(-) A-I      intronic
chr11:78174719(-) A-I      intronic
chr11:78190404(-) A-I      intronic
chr11:78174515(-) A-I      intronic
chr11:78197058(-) A-I      intronic
chr11:78231845(-) A-I      intronic
chr11:78213874(-) A-I      intronic
chr11:78232021(-) A-I      intronic
chr11:78222397(-) A-I      intronic
chr11:78281699(-) A-I      intronic
chr11:78171348(-) A-I      intronic
chr11:78211617(-) A-I      intronic
chr11:78212081(-) A-I      intronic
chr11:78172776(-) A-I      intronic
chr11:78211697(-) A-I      intronic
chr11:78224661(-) A-I      intronic
chr11:78233153(-) A-I      intronic
chr11:78233228(-) A-I      intronic
chr11:78174487(-) A-I      intronic
chr11:78171409(-) A-I      intronic
chr11:78212132(-) A-I      intronic
chr11:78213868(-) A-I      intronic
chr11:78174347(-) A-I      intronic
chr11:78212051(-) A-I      intronic
chr11:78214422(-) A-I      intronic
chr11:78233073(-) A-I      intronic
chr11:78155505(-) A-I      intronic
chr11:78216294(-) A-I      intronic
chr11:78148873(-) A-I      intronic
chr11:78148841(-) A-I      intronic
chr11:78150189(-) A-I      intronic
chr11:78156976(-) A-I      intronic
chr11:78158340(-) A-I      intronic
chr11:78174356(-) A-I      intronic
chr11:78232491(-) A-I      intronic
chr11:78232672(-) A-I      intronic
chr11:78152662(-) A-I      intronic
chr11:78174203(-) A-I      intronic
chr11:78274761(-) A-I      intronic
chr11:78148864(-) A-I      intronic
chr11:78212062(-) A-I      intronic
chr11:78148779(-) A-I      intronic
chr11:78273381(-) A-I      intronic
chr11:78155643(-) A-I      intronic
chr11:78213918(-) A-I      intronic
chr11:78220137(-) A-I      intronic
chr11:78219992(-) A-I      intronic
chr11:78232418(-) A-I      intronic
chr11:78224644(-) A-I      intronic
chr11:78214457(-) A-I      intronic
chr11:78233098(-) A-I      intronic
chr11:78233068(-) A-I      intronic
chr11:78163202(-) A-I      intronic
chr11:78179041(-) A-I      intronic
chr11:78214557(-) A-I      intronic
chr11:78174379(-) A-I      intronic
chr11:78232508(-) A-I      intronic
chr11:78174656(-) A-I      intronic
chr11:78217694(-) A-I      intronic
chr11:78155511(-) A-I      intronic
chr11:78200898(-) A-I      intronic
chr11:78174305(-) A-I      intronic
chr11:78171425(-) A-I      intronic
chr11:78212134(-) A-I      intronic
chr11:78217761(-) A-I      intronic
chr11:78220017(-) A-I      intronic
chr11:78174294(-) A-I      intronic
chr11:78213958(-) A-I      intronic
chr11:78232327(-) A-I      intronic
chr11:78148858(-) A-I      intronic
chr11:78174497(-) A-I      intronic
chr11:78255944(-) A-I      intronic
chr11:78231011(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED NARS2
chr11:78170025(-) A-G intron -    22484847
chr11:78170056(-) A-G intron -    22484847
chr11:78174203(-) A-G intron -    22484847
chr11:78174656(-) A-G intron -    22484847
chr11:78232327(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase NARS2
chr11:78147015-78147016(-) m6A 3'UTR       27773535
chr11:78285452-78285453(-) m6A CDS//intron       25456834//27371828//27773536
chr11:78285464-78285465(-) m6A CDS//intron       25456834//27371828//27773536
chr11:78285579-78285580(-) m6A 5'UTR//intron       24284625//25456834//27371828//27773536
chr11:78285702-78285703(-) m6A 5'UTR//intron       24284625//25456834//24981863//27371828//27773536//22575960

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-574-5p
Exosome Breast cancer cell line (MCF-7)     20976003
Exosome Breast milk     22211110
Exosome Plasma     23663360
Exosome Human mast cell line (HMC-1)     24009880
Exosome Breast milk|Seminal fluid     -
Extracellular vesicle Colon cancer cell line (LIM1863)     25330373
Microvesicle Seminal plasma     23539611
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
Mitochondrion Cell line (HEK-293|HeLa)     22984580
Nucleus LAC cell line (A549)     32231562
NARS2
Chromatin K562 cells     -
Cytosol HCC cell line (HepG2)|K562 cells     -
Exosome Blood     -
Insoluble cytoplasm HCC cell line (HepG2)     -
Membrane K562 cells     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -
Ribosome Colon cancer cells     24393600

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-574-5p
MMP-9/MMP-13 Inhibitor I 9983251 Drug resistant
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-574-5p
5-Fluorouracil 3385 Drug interaction    RC00007188
Ginsenoside Rh2 119307 Drug interaction    RC00007189
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-574-5p
Imatinib 5291       25349971
Resource Symbol Drug Name PubChem ID
RNAactDrug hsa-miR-574-5p
Panobinostat       6918837
Irinotecan       60838
Topotecan       60700
l-685,458       5479543
Palbociclib       5330286
Paclitaxel       36314
Sorafenib       216239
5-Chloro-N4-(2-(isopropylsulfonyl)phenyl)-N2-(2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)pyrimidine-2,4-diamine       16038120
Dovitinib       135398510
Crizotinib       11626560
Pha-665752       10461815

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-574-5p
Interactor2: NARS2

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region CDS
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

Starting a new search, please wait ...