Basic Information:

  VIRBase ID:  

HHID00067073

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-545-5p:  MIMAT0004785          GID8:  NM_017896     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-545-5p	GID8
miRBase Accession/Entrez ID	MIMAT0004785	54994
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	C20orf11//TWA1

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-545-5p	rs1220393171 chrX:74287172    T/A rs1291368863 chrX:74287173    A/G rs1469046677 chrX:74287167    T/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	GID8	chr20:61571854(+) A-I      intronic chr20:61570395(+) A-I      intronic chr20:61573565(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	GID8	chr20:61572871-61572872(+) m6A CDS       24981863 chr20:61572936-61572937(+) m6A CDS       24981863 chr20:61572942-61572943(+) m6A CDS       24981863 chr20:61572957-61572958(+) m6A CDS       24981863 chr20:61574424-61574425(+) Am CDS       - chr20:61574882-61574883(+) m6A CDS       24981863 chr20:61575015-61575016(+) m6A CDS       24284625//24209618//22575960//22608085 chr20:61576149-61576150(+) m6A CDS       24284625//24209618//24981863//27773535//22575960//22608085 chr20:61576167-61576168(+) m6A CDS       24284625//24209618//24981863//27773535//22575960//22608085 chr20:61576196-61576197(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr20:61576229-61576230(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr20:61576310-61576311(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr20:61576359-61576360(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr20:61576436-61576437(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr20:61576659-61576660(+) m6A 3'UTR       24284625//24209618//24981863 chr20:61576908-61576909(+) m6A 3'UTR       24209618 chr20:61576931-61576932(+) m6A 3'UTR       24209618 chr20:61577311-61577312(+) m6A 3'UTR       - chr20:61577380-61577381(+) m6A 3'UTR       - chr20:61577443-61577444(+) m6A 3'UTR       - chr20:61577700-61577701(+) m6A 3'UTR       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-545-5p	Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Mesenchymal stem cells     -
	GID8	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Insoluble cytoplasm K562 cells     - Membrane HCC cell line (HepG2)     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-545-5p
Interactor2: GID8

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	CDS
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.