Basic Information:

  VIRBase ID:  

HHID00067033

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-455-3p:  MIMAT0004784          ATXN1L:  NM_001137675     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-455-3p	ATXN1L
miRBase Accession/Entrez ID	MIMAT0004784	342371
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	BOAT//BOAT1

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-455-3p	rs1306463073 chr9:114209503    T/G rs1356418764 chr9:114209506    A/G rs569238209 chr9:114209498    G/A rs569238209 chr9:114209498    G/T rs747812999 chr9:114209499    C/T rs1374604579 chr9:114209488    C/A rs1445598669 chr9:114209492    C/G rs751085413 chr9:114209493    C/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	ATXN1L	chr16:71892629(+) A-I      intronic chr16:71892635(+) A-I      intronic chr16:71892610(+) A-I      intronic chr16:71907766(+) A-I      intronic chr16:71892567(+) A-I      intronic chr16:71892007(+) A-I      intronic chr16:71892283(+) A-I      intronic chr16:71892296(+) A-I      intronic chr16:71892075(+) A-I      intronic chr16:71892290(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	ATXN1L	chr16:71892251(+) T-C intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ATXN1L	chr16:71881933-71881934(+) m6A 5'UTR//exon       24284625 chr16:71881968-71881969(+) m6A 5'UTR//exon       24284625 chr16:71882035-71882036(+) m6A exon//intron       24284625//24981863 chr16:71882040-71882041(+) m6A exon//intron       24284625//24981863 chr16:71882298-71882299(+) m6A exon//intron       - chr16:71883628-71883629(+) m6A 5'UTR//intron       24284625//24209618 chr16:71883648-71883649(+) m6A CDS//intron       24284625//24209618 chr16:71883695-71883696(+) m6A CDS//intron       24284625//24209618//24981863 chr16:71883727-71883728(+) m6A CDS//intron       24284625//24209618//24981863 chr16:71883872-71883873(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr16:71883930-71883931(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22608085 chr16:71884304-71884305(+) m6A CDS//intron       24284625//24209618//24981863 chr16:71884375-71884376(+) m6A CDS//intron       24284625//24209618//24981863//22575960//22608085 chr16:71884455-71884456(+) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr16:71884461-71884462(+) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr16:71884536-71884537(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr16:71884569-71884570(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr16:71884591-71884592(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr16:71884630-71884631(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr16:71884637-71884638(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr16:71884685-71884686(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr16:71884719-71884720(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr16:71884787-71884788(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr16:71884848-71884849(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr16:71884857-71884858(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr16:71884863-71884864(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr16:71884915-71884916(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr16:71884997-71884998(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr16:71885102-71885103(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr16:71885110-71885111(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr16:71885177-71885178(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr16:71885399-71885400(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr16:71885502-71885503(+) Cm CDS//intron       - chr16:71885713-71885714(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863 chr16:71885726-71885727(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863 chr16:71885732-71885733(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863 chr16:71885903-71885904(+) m6A 3'UTR//intron       24284625 chr16:71886204-71886205(+) m6A 3'UTR//intron       - chr16:71888680-71888681(+) m6A 3'UTR//intron       - chr16:71888736-71888737(+) m6A 3'UTR//intron       - chr16:71889482-71889483(+) m6A 3'UTR//intron       24981863 chr16:71889541-71889542(+) m6A 3'UTR//intron       24981863//27773535 chr16:71893696-71893697(+) m6A intron       - chr16:71893796-71893797(+) m6A intron       - chr16:71893822-71893823(+) m6A intron       - chr16:71894060-71894061(+) m6A intron       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-455-3p	Exosome Pooled sera     27278097 Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Seminal plasma     23539611 Microvesicle Fibroblasts|Mesenchymal stem cells     - Mitochondrion Skeletal muscle myoblasts     21637849
	ATXN1L	Chromatin K562 cells     - Exosome Blood     - Nucleolus K562 cells     - Nucleus HeLa-S3 cells     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-455-3p	cis-Diaminedichloroplatinum 2767 Drug interaction    RC00007184

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-455-3p	Gemcitabine 60750       29499934 Prednisone 5865       24858372 Cisplatin 5702198       25356050 Cisplatin 5702198       28633632 Temozolomide 5394       20444541 Etoposide 36462       23028896 Doxorubicin 31703       24858372 Doxorubicin 31703       25698578 Cyclophosphamide 2907       24858372 Docetaxel 148124       28633632 Methyl (9R,10S,11S,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15R,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-8-formyl-10-hydroxy-5-methoxy-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate 134755071       24858372 Rituximab -       24858372

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	hsa-miR-455-3p	Panobinostat       6918837 l-685,458       5479543

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-455-3p
Interactor2: ATXN1L

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.