Basic Information:

  VIRBase ID:  

HHID00066875

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-502-3p:  MIMAT0004775          APAF1:  NM_181861     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-502-3p	APAF1
miRBase Accession/Entrez ID	MIMAT0004775	317
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	APAF-1//CED4

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-502-3p	rs1557183235 chrX:50014657    T/C rs1557183236 chrX:50014658    G/A rs781957096 chrX:50014669    C/T rs782397209 chrX:50014666    A/C rs1206203216 chrX:50014650    A/C rs1206203216 chrX:50014650    A/G rs1448298437 chrX:50014651    T/C rs1557183232 chrX:50014651    T/TA rs1557183233 chrX:50014653    C/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	APAF1	chr12:99047358(+) A-I      intronic chr12:99058893(+) A-I      intronic chr12:99112527(+) A-I      intronic chr12:99058856(+) A-I      intronic chr12:99112503(+) A-I      intronic chr12:99047363(+) A-I      intronic chr12:99047344(+) A-I      intronic chr12:99047337(+) A-I      intronic chr12:99047320(+) A-I      intronic chr12:99047384(+) A-I      intronic chr12:99047306(+) A-I      intronic chr12:99047380(+) A-I      intronic chr12:99047284(+) A-I      intronic chr12:99045537(+) A-I      intronic chr12:99045493(+) A-I      intronic chr12:99045966(+) A-I      intronic chr12:99127336(+) A-I      3'UTR chr12:99112512(+) A-I      intronic chr12:99044074(+) A-I      intronic chr12:99058920(+) A-I      intronic chr12:99044075(+) A-I      intronic chr12:99058912(+) A-I      intronic chr12:99058911(+) A-I      intronic chr12:99058894(+) A-I      intronic chr12:99045538(+) A-I      intronic chr12:99047369(+) A-I      intronic chr12:99066775(+) A-I      intronic chr12:99067003(+) A-I      intronic chr12:99067044(+) A-I      intronic chr12:99067097(+) A-I      intronic chr12:99067142(+) A-I      intronic chr12:99067780(+) A-I      intronic chr12:99081611(+) A-I      intronic chr12:99081646(+) A-I      intronic chr12:99081755(+) A-I      intronic chr12:99083355(+) A-I      intronic chr12:99083498(+) A-I      intronic chr12:99083501(+) A-I      intronic chr12:99083519(+) A-I      intronic chr12:99096341(+) A-I      intronic chr12:99096383(+) A-I      intronic chr12:99096598(+) A-I      intronic chr12:99112054(+) A-I      intronic chr12:99112213(+) A-I      intronic chr12:99113228(+) A-I      intronic chr12:99113269(+) A-I      intronic chr12:99114602(+) A-I      intronic chr12:99114624(+) A-I      intronic chr12:99114630(+) A-I      intronic chr12:99114708(+) A-I      intronic chr12:99114753(+) A-I      intronic chr12:99066788(+) A-I      intronic chr12:99044185(+) A-I      intronic chr12:99044221(+) A-I      intronic chr12:99045488(+) A-I      intronic chr12:99045632(+) A-I      intronic chr12:99045750(+) A-I      intronic chr12:99045993(+) A-I      intronic chr12:99046544(+) A-I      intronic chr12:99046664(+) A-I      intronic chr12:99046677(+) A-I      intronic chr12:99047239(+) A-I      intronic chr12:99047276(+) A-I      intronic chr12:99047285(+) A-I      intronic chr12:99047417(+) A-I      intronic chr12:99048262(+) A-I      intronic chr12:99048303(+) A-I      intronic chr12:99048315(+) A-I      intronic chr12:99048407(+) A-I      intronic chr12:99053328(+) A-I      intronic chr12:99053359(+) A-I      intronic chr12:99053846(+) A-I      intronic chr12:99053874(+) A-I      intronic chr12:99053943(+) A-I      intronic chr12:99066023(+) A-I      intronic chr12:99066650(+) A-I      intronic chr12:99066763(+) A-I      intronic chr12:99066770(+) A-I      intronic chr12:99045517(+) A-I      intronic chr12:99045616(+) A-I      intronic chr12:99082733(+) A-I      intronic chr12:99112589(+) A-I      intronic chr12:99067082(+) A-I      intronic chr12:99045609(+) A-I      intronic chr12:99112510(+) A-I      intronic chr12:99053868(+) A-I      intronic chr12:99047179(+) A-I      intronic chr12:99053963(+) A-I      intronic chr12:99047385(+) A-I      intronic chr12:99041339(+) A-I      intronic chr12:99045705(+) A-I      intronic chr12:99047180(+) A-I      intronic chr12:99044059(+) A-I      intronic chr12:99047376(+) A-I      intronic chr12:99067083(+) A-I      intronic chr12:99044102(+) A-I      intronic chr12:99112542(+) A-I      intronic chr12:99045657(+) A-I      intronic chr12:99128848(+) A-I      3'UTR chr12:99127401(+) A-I      3'UTR chr12:99128844(+) A-I      3'UTR chr12:99128793(+) A-I      3'UTR chr12:99128847(+) A-I      3'UTR chr12:99127171(+) A-I      3'UTR chr12:99128787(+) A-I      3'UTR chr12:99127451(+) A-I      3'UTR chr12:99128748(+) A-I      3'UTR chr12:99127337(+) A-I      3'UTR chr12:99127285(+) A-I      3'UTR chr12:99128792(+) A-I      3'UTR chr12:99112203(+) A-I      intronic chr12:99045462(+) A-I      intronic chr12:99045693(+) A-I      intronic chr12:99044051(+) A-I      intronic chr12:99047355(+) A-I      intronic chr12:99103852(+) A-I      intronic chr12:99047259(+) A-I      intronic chr12:99045767(+) A-I      intronic chr12:99096589(+) A-I      intronic chr12:99046522(+) A-I      intronic chr12:99047392(+) A-I      intronic chr12:99053410(+) A-I      intronic chr12:99045798(+) A-I      intronic chr12:99047367(+) A-I      intronic chr12:99045710(+) A-I      intronic chr12:99045470(+) A-I      intronic chr12:99112517(+) A-I      intronic chr12:99112499(+) A-I      intronic chr12:99045512(+) A-I      intronic chr12:99112531(+) A-I      intronic chr12:99045613(+) A-I      intronic chr12:99045507(+) A-I      intronic chr12:99049423(+) A-I      intronic chr12:99045654(+) A-I      intronic chr12:99113257(+) A-I      intronic chr12:99047315(+) A-I      intronic chr12:99046005(+) A-I      intronic chr12:99112222(+) A-I      intronic chr12:99055335(+) A-I      intronic chr12:99082643(+) A-I      intronic chr12:99053320(+) A-I      intronic chr12:99049431(+) A-I      intronic chr12:99065977(+) A-I      intronic chr12:99067848(+) A-I      intronic chr12:99067146(+) A-I      intronic chr12:99047314(+) A-I      intronic chr12:99045614(+) A-I      intronic chr12:99096607(+) A-I      intronic chr12:99045854(+) A-I      intronic chr12:99098577(+) A-I      intronic chr12:99045732(+) A-I      intronic chr12:99046479(+) A-I      intronic chr12:99113267(+) A-I      intronic chr12:99066115(+) A-I      intronic chr12:99112150(+) A-I      intronic chr12:99045940(+) A-I      intronic chr12:99047202(+) A-I      intronic chr12:99053917(+) A-I      intronic chr12:99045992(+) A-I      intronic chr12:99112661(+) A-I      intronic chr12:99045855(+) A-I      intronic chr12:99049466(+) A-I      intronic chr12:99054780(+) A-I      intronic chr12:99066178(+) A-I      intronic chr12:99045692(+) A-I      intronic chr12:99067159(+) A-I      intronic chr12:99045920(+) A-I      intronic chr12:99046423(+) A-I      intronic chr12:99047220(+) A-I      intronic chr12:99054026(+) A-I      intronic chr12:99054953(+) A-I      intronic chr12:99047279(+) A-I      intronic chr12:99055393(+) A-I      intronic chr12:99047356(+) A-I      intronic chr12:99054025(+) A-I      intronic chr12:99045952(+) A-I      intronic chr12:99045758(+) A-I      intronic chr12:99047225(+) A-I      intronic chr12:99047270(+) A-I      intronic chr12:99046482(+) A-I      intronic chr12:99054781(+) A-I      intronic chr12:99082766(+) A-I      intronic chr12:99122236(+) A-I      intronic chr12:99047249(+) A-I      intronic chr12:99112152(+) A-I      intronic chr12:99067134(+) A-I      intronic chr12:99112036(+) A-I      intronic chr12:99040907(+) A-I      intronic chr12:99054798(+) A-I      intronic chr12:99044060(+) A-I      intronic chr12:99047153(+) A-I      intronic chr12:99067967(+) A-I      intronic chr12:99112632(+) A-I      intronic chr12:99127474(+) A-I      3'UTR chr12:99127091(+) A-I      3'UTR chr12:99127447(+) A-I      3'UTR chr12:99126935(+) A-I      3'UTR chr12:99128771(+) A-I      3'UTR chr12:99127345(+) A-I      3'UTR chr12:99127030(+) A-I      3'UTR chr12:99127234(+) A-I      3'UTR chr12:99127464(+) A-I      3'UTR chr12:99127446(+) A-I      3'UTR chr12:99127473(+) A-I      3'UTR chr12:99127013(+) A-I      3'UTR chr12:99127315(+) A-I      3'UTR chr12:99128811(+) A-I      3'UTR chr12:99127409(+) A-I      3'UTR chr12:99126937(+) A-I      3'UTR chr12:99127094(+) A-I      3'UTR chr12:99128776(+) A-I      3'UTR chr12:99128770(+) A-I      3'UTR chr12:99127350(+) A-I      3'UTR chr12:99128830(+) A-I      3'UTR chr12:99127328(+) A-I      3'UTR chr12:99127311(+) A-I      3'UTR chr12:99127412(+) A-I      3'UTR

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	APAF1	chr12:99126937(+) A-I exon 3'UTR    15258596 chr12:99127013(+) A-I exon 3'UTR    15258596 chr12:99127234(+) A-I exon 3'UTR    15258596 chr12:99127328(+) A-I exon 3'UTR    15258596 chr12:99127337(+) A-I exon 3'UTR    15258596 chr12:99127350(+) A-I exon 3'UTR    15258596 chr12:99127446(+) A-I exon 3'UTR    15258596   //22327324 chr12:99127447(+) A-I exon 3'UTR    15258596   //22327324 chr12:99127474(+) A-I intron -    22327324 chr12:99128776(+) A-I intron -    22327324 chr12:99128811(+) A-I intron -    22327324 chr12:99127446(+) A-G intron -    21725310   //22484847 chr12:99127474(+) A-G intron -    21725310   //22484847 chr12:99128792(+) A-G intron -    21725310 chr12:99045654(+) A-G intron -    22484847 chr12:99045657(+) A-G intron -    22484847 chr12:99045710(+) A-G intron -    22484847 chr12:99110904(+) C-A intron -    22484847 chr12:99127315(+) A-G intron -    22484847 chr12:99127328(+) A-G intron -    22484847 chr12:99127337(+) A-G intron -    22484847 chr12:99127350(+) A-G intron -    22484847 chr12:99127447(+) A-G intron -    22484847 chr12:99044086(+) T-C intron -    22484847 chr12:99047270(+) A-G intron -    22484847 chr12:99047314(+) A-G intron -    22484847 chr12:99053868(+) A-G intron -    22484847 chr12:99053963(+) A-G intron -    22484847 chr12:99054025(+) A-G intron -    22484847 chr12:99054026(+) A-G intron -    22484847 chr12:99054781(+) A-G intron -    22484847 chr12:99054798(+) A-G intron -    22484847 chr12:99054953(+) A-G intron -    22484847 chr12:99065977(+) A-G intron -    22484847 chr12:99066115(+) A-G intron -    22484847 chr12:99066984(+) C-G intron -    22484847 chr12:99067082(+) A-G intron -    22484847 chr12:99067083(+) A-G intron -    22484847 chr12:99067146(+) A-G intron -    22484847 chr12:99067848(+) A-G intron -    22484847 chr12:99067967(+) A-G intron -    22484847 chr12:99081629(+) G-A intron -    22484847 chr12:99096607(+) A-G intron -    22484847 chr12:99106614(+) G-T intron -    22484847 chr12:99112036(+) A-G intron -    22484847 chr12:99112203(+) A-G intron -    22484847 chr12:99112589(+) A-G intron -    22484847 chr12:99126925(+) G-T intron -    22484847 chr12:99127234(+) A-G intron -    22484847 chr12:99127345(+) A-G intron -    22484847 chr12:99127401(+) A-G intron -    22484847 chr12:99127412(+) A-G intron -    22484847 chr12:99127458(+) T-C intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	APAF1	chr12:99039080-99039081(+) m1A 5'UTR       26863196//26863410 chr12:99039130-99039131(+) m6A 5'UTR       24284625//24209618//25456834//24981863//22608085 chr12:99039170-99039171(+) m6A 5'UTR       24284625//24209618//25456834//24981863//22608085 chr12:99039260-99039261(+) m6A 5'UTR       - chr12:99039337-99039338(+) m6A 5'UTR       - chr12:99039454-99039455(+) m6A 5'UTR       - chr12:99126332-99126333(+) m6A 3'UTR//CDS//exon       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-502-3p	Exosome B cell line (Raji)|Primary dendritic cells     21505438 Exosome Plasma     23663360 Exosome Human mast cell line (HMC-1)     24009880 Exosome Colon cancer cell line (LIM1863)     25330373 Exosome Blood     - Microvesicle Plasma     23077538 Microvesicle Seminal plasma     23539611 Microvesicle Blood|Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     - Mitochondrion Skeletal muscle myoblasts     21637849 Mitochondrion Cell line (HEK-293|HeLa)     22984580
	APAF1	Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytoplasm Nasopharyngeal carcinoma cells     20498841 Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus Nasopharyngeal carcinoma cells     20498841

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-502-3p
Interactor2: APAF1

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.