Basic Information:

  VIRBase ID:  

HHID00066839

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-500a-5p:  MIMAT0004773          TBK1:  NM_013254     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-500a-5p	TBK1
miRBase Accession/Entrez ID	MIMAT0004773	29110
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	FTDALS4//IIAE8//NAK//T2K

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-500a-5p	rs1221490724 chrX:50008465    A/G rs1557181893 chrX:50008443    T/G rs1557181895 chrX:50008452    C/G rs1557181897 chrX:50008453    T/A rs1557181900 chrX:50008458    G/A rs1557181900 chrX:50008458    G/C rs1557181904 chrX:50008463    A/T rs369176381 chrX:50008450    T/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	TBK1	chr12:64892621(+) A-I      intronic chr12:64894748(+) A-I      intronic chr12:64868794(+) A-I      intronic chr12:64868777(+) A-I      intronic chr12:64868775(+) A-I      intronic chr12:64894686(+) A-I      intronic chr12:64861753(+) A-I      intronic chr12:64886603(+) A-I      intronic chr12:64868767(+) A-I      intronic chr12:64868742(+) A-I      intronic chr12:64868736(+) A-I      intronic chr12:64886841(+) A-I      intronic chr12:64883442(+) A-I      intronic chr12:64886885(+) A-I      intronic chr12:64886873(+) A-I      intronic chr12:64886863(+) A-I      intronic chr12:64883478(+) A-I      intronic chr12:64886856(+) A-I      intronic chr12:64883474(+) A-I      intronic chr12:64886793(+) A-I      intronic chr12:64886739(+) A-I      intronic chr12:64882660(+) A-I      intronic chr12:64894774(+) A-I      intronic chr12:64894727(+) A-I      intronic chr12:64894722(+) A-I      intronic chr12:64894696(+) A-I      intronic chr12:64894656(+) A-I      intronic chr12:64886320(+) A-I      intronic chr12:64894643(+) A-I      intronic chr12:64894642(+) A-I      intronic chr12:64894600(+) A-I      intronic chr12:64861825(+) A-I      intronic chr12:64893087(+) A-I      intronic chr12:64893086(+) A-I      intronic chr12:64893059(+) A-I      intronic chr12:64893008(+) A-I      intronic chr12:64892999(+) A-I      intronic chr12:64882737(+) A-I      intronic chr12:64886314(+) A-I      intronic chr12:64886266(+) A-I      intronic chr12:64892904(+) A-I      intronic chr12:64892609(+) A-I      intronic chr12:64892607(+) A-I      intronic chr12:64886186(+) A-I      intronic chr12:64886216(+) A-I      intronic chr12:64886191(+) A-I      intronic chr12:64872060(+) A-I      intronic chr12:64886190(+) A-I      intronic chr12:64886187(+) A-I      intronic chr12:64886878(+) A-I      intronic chr12:64886151(+) A-I      intronic chr12:64883449(+) A-I      intronic chr12:64884587(+) A-I      intronic chr12:64892589(+) A-I      intronic chr12:64892489(+) A-I      intronic chr12:64888185(+) A-I      intronic chr12:64888122(+) A-I      intronic chr12:64888116(+) A-I      intronic chr12:64888095(+) A-I      intronic chr12:64887986(+) A-I      intronic chr12:64887362(+) A-I      intronic chr12:64883488(+) A-I      intronic chr12:64883479(+) A-I      intronic chr12:64887322(+) A-I      intronic chr12:64887276(+) A-I      intronic chr12:64887246(+) A-I      intronic chr12:64887211(+) A-I      intronic chr12:64887208(+) A-I      intronic chr12:64887187(+) A-I      intronic chr12:64865354(+) A-I      intronic chr12:64865353(+) A-I      intronic chr12:64865347(+) A-I      intronic chr12:64865298(+) A-I      intronic chr12:64865294(+) A-I      intronic chr12:64865236(+) A-I      intronic chr12:64857805(+) A-I      intronic chr12:64857341(+) A-I      intronic chr12:64857250(+) A-I      intronic chr12:64857229(+) A-I      intronic chr12:64857187(+) A-I      intronic chr12:64856964(+) A-I      intronic chr12:64892597(+) A-I      intronic chr12:64882596(+) A-I      intronic chr12:64867565(+) A-I      intronic chr12:64868634(+) A-I      intronic chr12:64868643(+) A-I      intronic chr12:64872024(+) A-I      intronic chr12:64872035(+) A-I      intronic chr12:64872048(+) A-I      intronic chr12:64872058(+) A-I      intronic chr12:64886936(+) A-I      intronic chr12:64882753(+) A-I      intronic chr12:64857841(+) A-I      intronic chr12:64892521(+) A-I      intronic chr12:64857894(+) A-I      intronic chr12:64886750(+) A-I      intronic chr12:64872034(+) A-I      intronic chr12:64888169(+) A-I      intronic chr12:64886702(+) A-I      intronic chr12:64886948(+) A-I      intronic chr12:64893105(+) A-I      intronic chr12:64894639(+) A-I      intronic chr12:64887314(+) A-I      intronic chr12:64892615(+) A-I      intronic chr12:64857297(+) A-I      intronic chr12:64884657(+) A-I      intronic chr12:64887197(+) A-I      intronic chr12:64886566(+) A-I      intronic chr12:64887151(+) A-I      intronic chr12:64883985(+) A-I      intronic chr12:64894760(+) A-I      intronic chr12:64888092(+) A-I      intronic chr12:64886825(+) A-I      intronic chr12:64887980(+) A-I      intronic chr12:64868732(+) A-I      intronic chr12:64883541(+) A-I      intronic chr12:64892981(+) A-I      intronic chr12:64867434(+) A-I      intronic chr12:64865074(+) A-I      intronic chr12:64887327(+) A-I      intronic chr12:64892693(+) A-I      intronic chr12:64887248(+) A-I      intronic chr12:64871978(+) A-I      intronic chr12:64894800(+) A-I      intronic chr12:64888125(+) A-I      intronic chr12:64883603(+) A-I      intronic chr12:64862152(+) A-I      intronic chr12:64885139(+) A-I      intronic chr12:64888065(+) A-I      intronic chr12:64884021(+) A-I      intronic chr12:64857369(+) A-I      intronic chr12:64861912(+) A-I      intronic chr12:64886815(+) A-I      intronic chr12:64865393(+) A-I      intronic chr12:64887413(+) A-I      intronic chr12:64868791(+) A-I      intronic chr12:64884480(+) A-I      intronic chr12:64888139(+) A-I      intronic chr12:64856990(+) A-I      intronic chr12:64887145(+) A-I      intronic chr12:64892503(+) A-I      intronic chr12:64884581(+) A-I      intronic chr12:64892571(+) A-I      intronic chr12:64857322(+) A-I      intronic chr12:64892498(+) A-I      intronic chr12:64885195(+) A-I      intronic chr12:64888115(+) A-I      intronic chr12:64872031(+) A-I      intronic chr12:64856896(+) A-I      intronic chr12:64857080(+) A-I      intronic chr12:64867596(+) A-I      intronic chr12:64872207(+) A-I      intronic chr12:64888078(+) A-I      intronic chr12:64892486(+) A-I      intronic chr12:64857324(+) A-I      intronic chr12:64888216(+) A-I      intronic chr12:64887286(+) A-I      intronic chr12:64857702(+) A-I      intronic chr12:64892480(+) A-I      intronic chr12:64883372(+) A-I      intronic chr12:64887987(+) A-I      intronic chr12:64865078(+) A-I      intronic chr12:64857005(+) A-I      intronic chr12:64893022(+) A-I      intronic chr12:64893068(+) A-I      intronic chr12:64867587(+) A-I      intronic chr12:64857858(+) A-I      intronic chr12:64857773(+) A-I      intronic chr12:64888211(+) A-I      intronic chr12:64872115(+) A-I      intronic chr12:64857785(+) A-I      intronic chr12:64888152(+) A-I      intronic chr12:64857903(+) A-I      intronic chr12:64892648(+) A-I      intronic chr12:64887328(+) A-I      intronic chr12:64888234(+) A-I      intronic chr12:64892458(+) A-I      intronic chr12:64886850(+) A-I      intronic chr12:64868642(+) A-I      intronic chr12:64888161(+) A-I      intronic chr12:64892481(+) A-I      intronic chr12:64857809(+) A-I      intronic chr12:64857916(+) A-I      intronic chr12:64865316(+) A-I      intronic chr12:64892656(+) A-I      intronic chr12:64892550(+) A-I      intronic chr12:64854387(+) A-I      intronic chr12:64886166(+) A-I      intronic chr12:64884582(+) A-I      intronic chr12:64887242(+) A-I      intronic chr12:64884454(+) A-I      intronic chr12:64882759(+) A-I      intronic chr12:64887249(+) A-I      intronic chr12:64886756(+) A-I      intronic chr12:64894719(+) A-I      intronic chr12:64892545(+) A-I      intronic chr12:64892923(+) A-I      intronic chr12:64877629(+) A-I      intronic chr12:64892576(+) A-I      intronic chr12:64883563(+) A-I      intronic chr12:64872139(+) A-I      intronic chr12:64885292(+) A-I      intronic chr12:64884517(+) A-I      intronic chr12:64892924(+) A-I      intronic chr12:64888123(+) A-I      intronic chr12:64877628(+) A-I      intronic chr12:64856974(+) A-I      intronic chr12:64886859(+) A-I      intronic chr12:64892632(+) A-I      intronic chr12:64892474(+) A-I      intronic chr12:64861839(+) A-I      intronic chr12:64893099(+) A-I      intronic chr12:64886204(+) A-I      intronic chr12:64857864(+) A-I      intronic chr12:64888008(+) A-I      intronic chr12:64854354(+) A-I      intronic chr12:64868813(+) A-I      intronic chr12:64887243(+) A-I      intronic chr12:64886780(+) A-I      intronic chr12:64867515(+) A-I      intronic chr12:64886242(+) A-I      intronic chr12:64857827(+) A-I      intronic chr12:64886921(+) A-I      intronic chr12:64894813(+) A-I      intronic chr12:64885256(+) A-I      intronic chr12:64893750(+) A-I      intronic chr12:64887270(+) A-I      intronic chr12:64892953(+) A-I      intronic chr12:64857031(+) A-I      intronic chr12:64892616(+) A-I      intronic chr12:64892511(+) A-I      intronic chr12:64892575(+) A-I      intronic chr12:64894741(+) A-I      intronic chr12:64892989(+) A-I      intronic chr12:64857699(+) A-I      intronic chr12:64867552(+) A-I      intronic chr12:64886896(+) A-I      intronic chr12:64888093(+) A-I      intronic chr12:64868740(+) A-I      intronic chr12:64888112(+) A-I      intronic chr12:64857210(+) A-I      intronic chr12:64857272(+) A-I      intronic chr12:64892625(+) A-I      intronic chr12:64887160(+) A-I      intronic chr12:64892691(+) A-I      intronic chr12:64883586(+) A-I      intronic chr12:64893005(+) A-I      intronic chr12:64892574(+) A-I      intronic chr12:64884014(+) A-I      intronic chr12:64867574(+) A-I      intronic chr12:64887247(+) A-I      intronic chr12:64892651(+) A-I      intronic chr12:64892580(+) A-I      intronic chr12:64888043(+) A-I      intronic chr12:64887178(+) A-I      intronic chr12:64892557(+) A-I      intronic chr12:64886831(+) A-I      intronic chr12:64857796(+) A-I      intronic chr12:64886881(+) A-I      intronic chr12:64886703(+) A-I      intronic chr12:64892577(+) A-I      intronic chr12:64887251(+) A-I      intronic chr12:64893668(+) A-I      intronic chr12:64867428(+) A-I      intronic chr12:64882563(+) A-I      intronic chr12:64857708(+) A-I      intronic chr12:64894801(+) A-I      intronic chr12:64867610(+) A-I      intronic chr12:64872030(+) A-I      intronic chr12:64884555(+) A-I      intronic chr12:64893658(+) A-I      intronic chr12:64857092(+) A-I      intronic chr12:64888192(+) A-I      intronic chr12:64892880(+) A-I      intronic chr12:64893578(+) A-I      intronic chr12:64872195(+) A-I      intronic chr12:64864973(+) A-I      intronic chr12:64856897(+) A-I      intronic chr12:64893077(+) A-I      intronic chr12:64886805(+) A-I      intronic chr12:64892893(+) A-I      intronic chr12:64882586(+) A-I      intronic chr12:64887206(+) A-I      intronic chr12:64857783(+) A-I      intronic chr12:64887287(+) A-I      intronic chr12:64886817(+) A-I      intronic chr12:64865019(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	TBK1	chr12:64857092(+) A-I intron -    22327324 chr12:64887980(+) A-I intron -    22327324 chr12:64854387(+) A-I intron -    21960545 chr12:64861753(+) A-I intron -    21960545 chr12:64865048(+) A-I intron -    21960545 chr12:64893578(+) A-I intron -    21960545 chr12:64857092(+) A-G intron -    22484847 chr12:64857702(+) A-G intron -    22484847 chr12:64861912(+) A-G intron -    22484847 chr12:64862185(+) T-C intron -    22484847 chr12:64865019(+) A-G intron -    22484847 chr12:64886815(+) A-G intron -    22484847 chr12:64886825(+) A-G intron -    22484847 chr12:64887242(+) A-G intron -    22484847 chr12:64887247(+) A-G intron -    22484847 chr12:64887248(+) A-G intron -    22484847 chr12:64887286(+) A-G intron -    22484847 chr12:64887314(+) A-G intron -    22484847 chr12:64887980(+) A-G intron -    22484847 chr12:64888125(+) A-G intron -    22484847 chr12:64888169(+) A-G intron -    22484847 chr12:64888192(+) A-G intron -    22484847 chr12:64892511(+) A-G intron -    22484847 chr12:64892521(+) A-G intron -    22484847 chr12:64892545(+) A-G intron -    22484847 chr12:64892577(+) A-G intron -    22484847 chr12:64893668(+) A-G intron -    22484847 chr12:64857005(+) A-G intron -    22484847 chr12:64857324(+) A-G intron -    22484847 chr12:64857650(+) G-T intron -    22484847 chr12:64857651(+) T-G intron -    22484847 chr12:64857663(+) G-T intron -    22484847 chr12:64857708(+) A-G intron -    22484847 chr12:64857746(+) T-C intron -    22484847 chr12:64857763(+) T-C intron -    22484847 chr12:64857783(+) A-G intron -    22484847 chr12:64857785(+) A-G intron -    22484847 chr12:64857809(+) A-G intron -    22484847 chr12:64857827(+) A-G intron -    22484847 chr12:64857833(+) C-A intron -    22484847 chr12:64857841(+) A-G intron -    22484847 chr12:64857858(+) A-G intron -    22484847 chr12:64857864(+) A-G intron -    22484847 chr12:64857894(+) A-G intron -    22484847 chr12:64857916(+) A-G intron -    22484847 chr12:64861839(+) A-G intron -    22484847 chr12:64864973(+) A-G intron -    22484847 chr12:64865316(+) A-G intron -    22484847 chr12:64867428(+) A-G intron -    22484847 chr12:64867610(+) A-G intron -    22484847 chr12:64868642(+) A-G intron -    22484847 chr12:64872031(+) A-G intron -    22484847 chr12:64872034(+) A-G intron -    22484847 chr12:64872115(+) A-G intron -    22484847 chr12:64872139(+) A-G intron -    22484847 chr12:64882563(+) A-G intron -    22484847 chr12:64882586(+) A-G intron -    22484847 chr12:64884582(+) A-G intron -    22484847 chr12:64885238(+) A-T intron -    22484847 chr12:64885256(+) A-G intron -    22484847 chr12:64886166(+) A-G intron -    22484847 chr12:64886204(+) A-G intron -    22484847 chr12:64886756(+) A-G intron -    22484847 chr12:64886805(+) A-G intron -    22484847 chr12:64886817(+) A-G intron -    22484847 chr12:64886881(+) A-G intron -    22484847 chr12:64886896(+) A-G intron -    22484847 chr12:64886921(+) A-G intron -    22484847 chr12:64886948(+) A-G intron -    22484847 chr12:64887145(+) A-G intron -    22484847 chr12:64887160(+) A-G intron -    22484847 chr12:64887178(+) A-G intron -    22484847 chr12:64887287(+) A-G intron -    22484847 chr12:64887328(+) A-G intron -    22484847 chr12:64892458(+) A-G intron -    22484847 chr12:64892481(+) A-G intron -    22484847 chr12:64892498(+) A-G intron -    22484847 chr12:64892550(+) A-G intron -    22484847 chr12:64892571(+) A-G intron -    22484847 chr12:64892616(+) A-G intron -    22484847 chr12:64892839(+) C-T intron -    22484847 chr12:64892893(+) A-G intron -    22484847 chr12:64892923(+) A-G intron -    22484847 chr12:64892924(+) A-G intron -    22484847 chr12:64892981(+) A-G intron -    22484847 chr12:64893005(+) A-G intron -    22484847 chr12:64893022(+) A-G intron -    22484847 chr12:64893077(+) A-G intron -    22484847 chr12:64893767(+) T-C intron -    22484847 chr12:64894719(+) A-G intron -    22484847 chr12:64894741(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	TBK1	chr12:64845957-64845958(+) m6A 5'UTR       24981863 chr12:64889377-64889378(+) m6A CDS//exon       24981863 chr12:64889487-64889488(+) m6A CDS//exon       24981863 chr12:64889540-64889541(+) m6A CDS//exon       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-500a-5p	Exosome Primary dendritic cells     21505438 Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Seminal plasma     23539611 Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     - Mitochondrion Skeletal muscle myoblasts     21637849 Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
	TBK1	Chromatin K562 cells     - Cytosol K562 cells     - Exosome Blood     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-500a-5p
Interactor2: TBK1

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	CDS
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.