Basic Information:

  VIRBase ID:  

HHID00066838

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-500a-5p:  MIMAT0004773          DUSP14:  NM_007026     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-500a-5p	DUSP14
miRBase Accession/Entrez ID	MIMAT0004773	11072
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	MKP-L//MKP6

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-500a-5p	rs1221490724 chrX:50008465    A/G rs1557181893 chrX:50008443    T/G rs1557181895 chrX:50008452    C/G rs1557181897 chrX:50008453    T/A rs1557181900 chrX:50008458    G/A rs1557181900 chrX:50008458    G/C rs1557181904 chrX:50008463    A/T rs369176381 chrX:50008450    T/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	DUSP14	chr17:35856902(+) A-I      intronic chr17:35865077(+) A-I      intronic chr17:35865059(+) A-I      intronic chr17:35861812(+) A-I      intronic chr17:35856766(+) A-I      intronic chr17:35856840(+) A-I      intronic chr17:35856970(+) A-I      intronic chr17:35857313(+) A-I      intronic chr17:35857918(+) A-I      intronic chr17:35859904(+) A-I      intronic chr17:35869686(+) A-I      intronic chr17:35859546(+) A-I      intronic chr17:35867756(+) A-I      intronic chr17:35866316(+) A-I      intronic chr17:35866296(+) A-I      intronic chr17:35866136(+) A-I      intronic chr17:35866122(+) A-I      intronic chr17:35865098(+) A-I      intronic chr17:35865139(+) A-I      intronic chr17:35859775(+) A-I      intronic chr17:35869440(+) A-I      intronic chr17:35859910(+) A-I      intronic chr17:35859912(+) A-I      intronic chr17:35865011(+) A-I      intronic chr17:35864090(+) A-I      intronic chr17:35864066(+) A-I      intronic chr17:35864080(+) A-I      intronic chr17:35864059(+) A-I      intronic chr17:35864850(+) A-I      intronic chr17:35855803(+) A-I      intronic chr17:35862392(+) A-I      intronic chr17:35863094(+) A-I      intronic chr17:35859753(+) A-I      intronic chr17:35869626(+) A-I      intronic chr17:35869603(+) A-I      intronic chr17:35867658(+) A-I      intronic chr17:35867638(+) A-I      intronic chr17:35866251(+) A-I      intronic chr17:35866190(+) A-I      intronic chr17:35866135(+) A-I      intronic chr17:35866114(+) A-I      intronic chr17:35866106(+) A-I      intronic chr17:35865187(+) A-I      intronic chr17:35857692(+) A-I      intronic chr17:35857682(+) A-I      intronic chr17:35857361(+) A-I      intronic chr17:35857310(+) A-I      intronic chr17:35856808(+) A-I      intronic chr17:35856684(+) A-I      intronic chr17:35856673(+) A-I      intronic chr17:35856660(+) A-I      intronic chr17:35855883(+) A-I      intronic chr17:35855869(+) A-I      intronic chr17:35867742(+) A-I      intronic chr17:35868584(+) A-I      intronic chr17:35856804(+) A-I      intronic chr17:35865384(+) A-I      intronic chr17:35867676(+) A-I      intronic chr17:35868606(+) A-I      intronic chr17:35865072(+) A-I      intronic chr17:35866119(+) A-I      intronic chr17:35869633(+) A-I      intronic chr17:35867659(+) A-I      intronic chr17:35865282(+) A-I      intronic chr17:35863347(+) A-I      intronic chr17:35863119(+) A-I      intronic chr17:35863447(+) A-I      intronic chr17:35857635(+) A-I      intronic chr17:35861862(+) A-I      intronic chr17:35863071(+) A-I      intronic chr17:35867628(+) A-I      intronic chr17:35865234(+) A-I      intronic chr17:35856710(+) A-I      intronic chr17:35858045(+) A-I      intronic chr17:35862391(+) A-I      intronic chr17:35864777(+) A-I      intronic chr17:35866191(+) A-I      intronic chr17:35856702(+) A-I      intronic chr17:35863453(+) A-I      intronic chr17:35862492(+) A-I      intronic chr17:35856044(+) A-I      intronic chr17:35867807(+) A-I      intronic chr17:35864250(+) A-I      intronic chr17:35864907(+) A-I      intronic chr17:35856544(+) A-I      intronic chr17:35865458(+) A-I      intronic chr17:35868585(+) A-I      intronic chr17:35869562(+) A-I      intronic chr17:35863420(+) A-I      intronic chr17:35863103(+) A-I      intronic chr17:35856437(+) A-I      intronic chr17:35866185(+) A-I      intronic chr17:35857958(+) A-I      intronic chr17:35863388(+) A-I      intronic chr17:35861806(+) A-I      intronic chr17:35856762(+) A-I      intronic chr17:35863276(+) A-I      intronic chr17:35856439(+) A-I      intronic chr17:35863377(+) A-I      intronic chr17:35861852(+) A-I      intronic chr17:35861885(+) A-I      intronic chr17:35869500(+) A-I      intronic chr17:35867724(+) A-I      intronic chr17:35866154(+) A-I      intronic chr17:35865107(+) A-I      intronic chr17:35862306(+) A-I      intronic chr17:35856895(+) A-I      intronic chr17:35857521(+) A-I      intronic chr17:35863302(+) A-I      intronic chr17:35863275(+) A-I      intronic chr17:35869442(+) A-I      intronic chr17:35863306(+) A-I      intronic chr17:35858031(+) A-I      intronic chr17:35856756(+) A-I      intronic chr17:35861897(+) A-I      intronic chr17:35859499(+) A-I      intronic chr17:35865245(+) A-I      intronic chr17:35864823(+) A-I      intronic chr17:35869606(+) A-I      intronic chr17:35868590(+) A-I      intronic chr17:35857712(+) A-I      intronic chr17:35865413(+) A-I      intronic chr17:35867739(+) A-I      intronic chr17:35857810(+) A-I      intronic chr17:35866214(+) A-I      intronic chr17:35863345(+) A-I      intronic chr17:35856557(+) A-I      intronic chr17:35867615(+) A-I      intronic chr17:35867827(+) A-I      intronic chr17:35856701(+) A-I      intronic chr17:35856841(+) A-I      intronic chr17:35857708(+) A-I      intronic chr17:35866159(+) A-I      intronic chr17:35868568(+) A-I      intronic chr17:35867704(+) A-I      intronic chr17:35857710(+) A-I      intronic chr17:35864758(+) A-I      intronic chr17:35864950(+) A-I      intronic chr17:35866217(+) A-I      intronic chr17:35868663(+) A-I      intronic chr17:35866220(+) A-I      intronic chr17:35856453(+) A-I      intronic chr17:35856047(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	DUSP14	chr17:35851633-35851634(+) m6A 5'UTR//intron       24284625//24981863 chr17:35851640-35851641(+) m6A 5'UTR//intron       24284625//24981863 chr17:35870735-35870736(+) m6A 5'UTR//intron       24981863 chr17:35870819-35870820(+) m6A 5'UTR       24284625//24209618//24981863 chr17:35870834-35870835(+) m6A 5'UTR       24284625//24209618//24981863 chr17:35870854-35870855(+) m6A 5'UTR       24284625//24209618//24981863 chr17:35872289-35872290(+) m6A 5'UTR       24284625//24209618//24981863 chr17:35872325-35872326(+) m6A 5'UTR       24284625//24209618//24981863//26404942//22608085 chr17:35872407-35872408(+) m6A CDS       24284625//24209618//24981863//26404942//22608085 chr17:35872441-35872442(+) m6A CDS       24284625//24209618//24981863//26404942//22608085 chr17:35872634-35872635(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr17:35872852-35872853(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr17:35872899-35872900(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-500a-5p	Exosome Primary dendritic cells     21505438 Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Seminal plasma     23539611 Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     - Mitochondrion Skeletal muscle myoblasts     21637849 Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
	DUSP14	Chromatin K562 cells     - Cytosol HeLa-S3 cells     - Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-500a-5p
Interactor2: DUSP14

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.