Basic Information:

  VIRBase ID:  

HHID00066779

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-146b-3p:  MIMAT0004766          YAE1:  NM_001282446     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-146b-3p	YAE1
miRBase Accession/Entrez ID	MIMAT0004766	57002
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	C7orf36//CIAB2//GK003//YAE1D1

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-146b-3p	rs1367942461 chr10:102436557    G/A rs1467375133 chr10:102436569    C/A rs766852690 chr10:102436575    TGGTGCCC/T rs768018523 chr10:102436577    G/C rs1425832655 chr10:102436558    C/T rs944616447 chr10:102436564    G/A

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	YAE1	chr7:39620052(+) A-I      intronic chr7:39620055(+) A-I      intronic chr7:39616544(+) A-I      intronic chr7:39614001(+) A-I      intronic chr7:39616549(+) A-I      intronic chr7:39613935(+) A-I      intronic chr7:39621367(+) A-I      intronic chr7:39621355(+) A-I      intronic chr7:39621323(+) A-I      intronic chr7:39621284(+) A-I      intronic chr7:39621257(+) A-I      intronic chr7:39616729(+) A-I      intronic chr7:39616716(+) A-I      intronic chr7:39616757(+) A-I      intronic chr7:39616769(+) A-I      intronic chr7:39621310(+) A-I      intronic chr7:39616680(+) A-I      intronic chr7:39621251(+) A-I      intronic chr7:39613996(+) A-I      intronic chr7:39613995(+) A-I      intronic chr7:39621451(+) A-I      intronic chr7:39621588(+) A-I      intronic chr7:39616715(+) A-I      intronic chr7:39621591(+) A-I      intronic chr7:39621431(+) A-I      intronic chr7:39621854(+) A-I      intronic chr7:39616704(+) A-I      intronic chr7:39616695(+) A-I      intronic chr7:39616678(+) A-I      intronic chr7:39614099(+) A-I      intronic chr7:39616660(+) A-I      intronic chr7:39621867(+) A-I      intronic chr7:39640097(+) A-I      intronic chr7:39613988(+) A-I      intronic chr7:39616568(+) A-I      intronic chr7:39616557(+) A-I      intronic chr7:39614459(+) A-I      intronic chr7:39614419(+) A-I      intronic chr7:39614282(+) A-I      intronic chr7:39614281(+) A-I      intronic chr7:39614273(+) A-I      intronic chr7:39621396(+) A-I      intronic chr7:39621566(+) A-I      intronic chr7:39621631(+) A-I      intronic chr7:39621450(+) A-I      intronic chr7:39621215(+) A-I      intronic chr7:39619403(+) A-I      intronic chr7:39614036(+) A-I      intronic chr7:39616633(+) A-I      intronic chr7:39613968(+) A-I      intronic chr7:39621289(+) A-I      intronic chr7:39607821(+) A-I      intronic chr7:39614374(+) A-I      intronic chr7:39607687(+) A-I      intronic chr7:39619451(+) A-I      intronic chr7:39621644(+) A-I      intronic chr7:39614103(+) A-I      intronic chr7:39621656(+) A-I      intronic chr7:39637689(+) A-I      intronic chr7:39621405(+) A-I      intronic chr7:39614180(+) A-I      intronic chr7:39616558(+) A-I      intronic chr7:39621821(+) A-I      intronic chr7:39621347(+) A-I      intronic chr7:39621269(+) A-I      intronic chr7:39614100(+) A-I      intronic chr7:39625803(+) A-I      intronic chr7:39616611(+) A-I      intronic chr7:39621380(+) A-I      intronic chr7:39607686(+) A-I      intronic chr7:39614320(+) A-I      intronic chr7:39614076(+) A-I      intronic chr7:39621320(+) A-I      intronic chr7:39616524(+) A-I      intronic chr7:39614383(+) A-I      intronic chr7:39616571(+) A-I      intronic chr7:39621780(+) A-I      intronic chr7:39614060(+) A-I      intronic chr7:39621270(+) A-I      intronic chr7:39621543(+) A-I      intronic chr7:39621275(+) A-I      intronic chr7:39619380(+) A-I      intronic chr7:39616756(+) A-I      intronic chr7:39614083(+) A-I      intronic chr7:39641238(+) A-I      intronic chr7:39621216(+) A-I      intronic chr7:39621404(+) A-I      intronic chr7:39614171(+) A-I      intronic chr7:39621596(+) A-I      intronic chr7:39614098(+) A-I      intronic chr7:39613948(+) A-I      intronic chr7:39614261(+) A-I      intronic chr7:39621630(+) A-I      intronic chr7:39614401(+) A-I      intronic chr7:39621391(+) A-I      intronic chr7:39621379(+) A-I      intronic chr7:39621221(+) A-I      intronic chr7:39621377(+) A-I      intronic chr7:39621668(+) A-I      intronic chr7:39621626(+) A-I      intronic chr7:39621373(+) A-I      intronic chr7:39621324(+) A-I      intronic chr7:39621653(+) A-I      intronic chr7:39621262(+) A-I      intronic chr7:39621233(+) A-I      intronic chr7:39624371(+) A-I      intronic chr7:39614295(+) A-I      intronic chr7:39638716(+) A-I      intronic chr7:39616550(+) A-I      intronic chr7:39616538(+) A-I      intronic chr7:39614032(+) A-I      intronic chr7:39614156(+) A-I      intronic chr7:39621390(+) A-I      intronic chr7:39607690(+) A-I      intronic

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-146b-3p	Exosome Pulmonary epithelial cell line (BEAS-2B)     31520698 Exosome Plasma     23663360 Exosome Mast cells     - Microvesicle Fibroblasts|Mesenchymal stem cells     -
	YAE1	Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Insoluble cytoplasm HCC cell line (HepG2)     - Nucleoplasm K562 cells     - Ribosome Colon cancer cells     24393600

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	hsa-miR-146b-3p	l-685,458       5479543

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-146b-3p
Interactor2: YAE1

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	CDS
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.