Basic Information:

  VIRBase ID:  

HHID00066775

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-146b-3p:  MIMAT0004766          AHSA1:  NM_012111     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-146b-3p	AHSA1
miRBase Accession/Entrez ID	MIMAT0004766	10598
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	AHA1//C14orf3//hAha1//p38

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-146b-3p	rs1367942461 chr10:102436557    G/A rs1467375133 chr10:102436569    C/A rs766852690 chr10:102436575    TGGTGCCC/T rs768018523 chr10:102436577    G/C rs1425832655 chr10:102436558    C/T rs944616447 chr10:102436564    G/A

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	AHSA1	chr14:77933880(+) A-I      intronic chr14:77933877(+) A-I      intronic chr14:77933876(+) A-I      intronic chr14:77933859(+) A-I      intronic chr14:77933858(+) A-I      intronic chr14:77932464(+) A-I      intronic chr14:77932463(+) A-I      intronic chr14:77933849(+) A-I      intronic chr14:77932336(+) A-I      intronic chr14:77932553(+) A-I      intronic chr14:77933851(+) A-I      intronic chr14:77933894(+) A-I      intronic chr14:77933464(+) A-I      intronic chr14:77927009(+) A-I      intronic chr14:77932331(+) A-I      intronic chr14:77927070(+) A-I      intronic chr14:77927801(+) A-I      intronic chr14:77933635(+) A-I      intronic chr14:77933582(+) A-I      intronic chr14:77927839(+) A-I      intronic chr14:77933661(+) A-I      intronic chr14:77932414(+) A-I      intronic chr14:77932415(+) A-I      intronic chr14:77933803(+) A-I      intronic chr14:77932580(+) A-I      intronic chr14:77932440(+) A-I      intronic chr14:77933898(+) A-I      intronic chr14:77933667(+) A-I      intronic chr14:77927423(+) A-I      intronic chr14:77927008(+) A-I      intronic chr14:77933470(+) A-I      intronic chr14:77932270(+) A-I      intronic chr14:77933657(+) A-I      intronic chr14:77927341(+) A-I      intronic chr14:77933834(+) A-I      intronic chr14:77927340(+) A-I      intronic chr14:77926933(+) A-I      intronic chr14:77927034(+) A-I      intronic chr14:77926995(+) A-I      intronic chr14:77933621(+) A-I      intronic chr14:77932454(+) A-I      intronic chr14:77932462(+) A-I      intronic chr14:77927391(+) A-I      intronic chr14:77927752(+) A-I      intronic chr14:77927012(+) A-I      intronic chr14:77933518(+) A-I      intronic chr14:77927038(+) A-I      intronic chr14:77927823(+) A-I      intronic chr14:77933580(+) A-I      intronic chr14:77933697(+) A-I      intronic chr14:77932239(+) A-I      intronic chr14:77932273(+) A-I      intronic chr14:77927504(+) A-I      intronic chr14:77927103(+) A-I      intronic chr14:77927828(+) A-I      intronic chr14:77933627(+) A-I      intronic chr14:77932402(+) A-I      intronic chr14:77927044(+) A-I      intronic chr14:77935256(+) A-I      intronic chr14:77933886(+) A-I      intronic chr14:77932335(+) A-I      intronic chr14:77932234(+) A-I      intronic chr14:77932263(+) A-I      intronic chr14:77927619(+) A-I      intronic chr14:77927381(+) A-I      intronic chr14:77933906(+) A-I      intronic chr14:77927459(+) A-I      intronic chr14:77927736(+) A-I      intronic chr14:77933487(+) A-I      intronic chr14:77933478(+) A-I      intronic chr14:77933940(+) A-I      intronic chr14:77933883(+) A-I      intronic chr14:77935139(+) A-I      intronic chr14:77927696(+) A-I      intronic chr14:77927355(+) A-I      intronic chr14:77932432(+) A-I      intronic chr14:77933691(+) A-I      intronic chr14:77932442(+) A-I      intronic chr14:77933987(+) A-I      intronic chr14:77926970(+) A-I      intronic chr14:77932383(+) A-I      intronic chr14:77932351(+) A-I      intronic chr14:77933917(+) A-I      intronic chr14:77927726(+) A-I      intronic chr14:77933588(+) A-I      intronic chr14:77933522(+) A-I      intronic chr14:77933595(+) A-I      intronic chr14:77927776(+) A-I      intronic chr14:77932554(+) A-I      intronic chr14:77933527(+) A-I      intronic chr14:77932342(+) A-I      intronic chr14:77933890(+) A-I      intronic chr14:77933583(+) A-I      intronic chr14:77932315(+) A-I      intronic chr14:77933611(+) A-I      intronic chr14:77933773(+) A-I      intronic chr14:77933782(+) A-I      intronic chr14:77932250(+) A-I      intronic chr14:77927046(+) A-I      intronic chr14:77933955(+) A-I      intronic chr14:77932400(+) A-I      intronic chr14:77933916(+) A-I      intronic chr14:77932593(+) A-I      intronic chr14:77927753(+) A-I      intronic chr14:77932441(+) A-I      intronic chr14:77926989(+) A-I      intronic chr14:77932309(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	AHSA1	chr14:77927103(+) A-I intron -    22327324 chr14:77927103(+) A-G intron -    22484847 chr14:77932331(+) A-G intron -    22484847 chr14:77932342(+) A-G intron -    22484847 chr14:77933580(+) A-G intron -    22484847 chr14:77933582(+) A-G intron -    22484847 chr14:77933595(+) A-G intron -    22484847 chr14:77933890(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	AHSA1	chr14:77924281-77924282(+) m6A 5'UTR       24981863 chr14:77924318-77924319(+) m6A 5'UTR       24284625//24209618//24981863 chr14:77924554-77924555(+) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//26404942//27371828//22575960 chr14:77926001-77926002(+) m6A 5'UTR//CDS//exon       24209618//24981863//26404942//27773535//22575960 chr14:77926035-77926036(+) m1A 5'UTR//CDS//exon       26863196 chr14:77926105-77926106(+) m6A 5'UTR//CDS//exon       24209618//26404942//27773535 chr14:77926135-77926136(+) m6A 5'UTR//CDS//exon       26404942//27773535 chr14:77926140-77926141(+) m6A 5'UTR//CDS//exon       26404942//27773535 chr14:77926145-77926146(+) m6A 5'UTR//CDS//exon       26404942//27773535 chr14:77928533-77928534(+) m6A 5'UTR//CDS//exon       24981863//27773535 chr14:77928565-77928566(+) m6A 5'UTR//CDS//exon       24981863//27773535 chr14:77928998-77928999(+) Y 5'UTR//CDS//exon//intron       26075521 chr14:77929055-77929056(+) m6A CDS//exon//intron       24981863//26404942//27773535 chr14:77929098-77929099(+) m6A CDS//exon//intron       24981863//26404942//27773535 chr14:77929154-77929155(+) m6A exon//intron       24981863//27773535 chr14:77929173-77929174(+) m6A exon//intron       24981863//27773535 chr14:77929423-77929424(+) m6A exon//intron       24981863//26404942 chr14:77930988-77930989(+) m6A CDS//exon//intron       24981863//26404942 chr14:77931014-77931015(+) m6A CDS//exon//intron       24981863//26404942 chr14:77931902-77931903(+) m6A CDS//exon//intron       24981863//26404942 chr14:77931913-77931914(+) m6A CDS//exon//intron       24981863//26404942 chr14:77931959-77931960(+) m6A CDS//exon//intron       26404942 chr14:77934468-77934469(+) m6A CDS//exon//intron       26404942//27773535//22575960 chr14:77934548-77934549(+) m6A 3'UTR//intron       27773535//22575960 chr14:77934597-77934598(+) m6A 3'UTR//intron       27773535 chr14:77934783-77934784(+) Y intron       25192136 chr14:77934810-77934811(+) m6A CDS//exon//intron       22575960 chr14:77934979-77934980(+) m6A 3'UTR//intron       22575960 chr14:77935000-77935001(+) m6A 3'UTR//intron       22575960 chr14:77935368-77935369(+) m6A 3'UTR//intron       24284625//24981863 chr14:77935380-77935381(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr14:77935393-77935394(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr14:77935420-77935421(+) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr14:77935466-77935467(+) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr14:77935482-77935483(+) Am 3'UTR//CDS//exon       - chr14:77935558-77935559(+) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr14:77935607-77935608(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr14:77935622-77935623(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr14:77935798-77935799(+) m6A 3'UTR//exon       24284625//24981863//22608085 chr14:77935812-77935813(+) m6A 3'UTR//exon       24284625//24981863//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-146b-3p	Exosome Pulmonary epithelial cell line (BEAS-2B)     31520698 Exosome Plasma     23663360 Exosome Mast cells     - Microvesicle Fibroblasts|Mesenchymal stem cells     -
	AHSA1	Chromatin K562 cells     - Cytosol K562 cells     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)     - Ribosome Colon cancer cells     24393600

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	hsa-miR-146b-3p	l-685,458       5479543

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-146b-3p
Interactor2: AHSA1

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	CDS
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.