Detail Information

Basic Information:


  VIRBase ID:  

HHID00066774

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-146b-3p:           TSC22D2:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-146b-3p TSC22D2
miRBase
Accession/Entrez ID		 MIMAT0004766 9819
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - TILZ4a//TILZ4b//TILZ4c

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-146b-3p
rs1367942461 chr10:102436557    G/A
rs1467375133 chr10:102436569    C/A
rs766852690 chr10:102436575    TGGTGCCC/T
rs768018523 chr10:102436577    G/C
rs1425832655 chr10:102436558    C/T
rs944616447 chr10:102436564    G/A

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR TSC22D2
chr3:150171326(+) A-I      intronic
chr3:150171325(+) A-I      intronic
chr3:150152869(+) A-I      intronic
chr3:150152118(+) A-I      intronic
chr3:150152078(+) A-I      intronic
chr3:150152877(+) A-I      intronic
chr3:150152920(+) A-I      intronic
chr3:150152823(+) A-I      intronic
chr3:150169671(+) A-I      intronic
chr3:150169999(+) A-I      intronic
chr3:150152149(+) A-I      intronic
chr3:150152809(+) A-I      intronic
chr3:150152126(+) A-I      intronic
chr3:150170240(+) A-I      intronic
chr3:150175623(+) A-I      intronic
chr3:150175391(+) A-I      intronic
chr3:150175368(+) A-I      intronic
chr3:150151709(+) A-I      intronic
chr3:150151702(+) A-I      intronic
chr3:150151700(+) A-I      intronic
chr3:150151699(+) A-I      intronic
chr3:150151652(+) A-I      intronic
chr3:150151637(+) A-I      intronic
chr3:150151629(+) A-I      intronic
chr3:150151957(+) A-I      intronic
chr3:150152059(+) A-I      intronic
chr3:150169748(+) A-I      intronic
chr3:150151741(+) A-I      intronic
chr3:150160518(+) A-I      intronic
chr3:150151742(+) A-I      intronic
chr3:150152113(+) A-I      intronic
chr3:150170153(+) A-I      intronic
chr3:150152029(+) A-I      intronic
chr3:150143222(+) A-I      intronic
chr3:150175516(+) A-I      intronic
chr3:150152204(+) A-I      intronic
chr3:150152904(+) A-I      intronic
chr3:150133481(+) A-I      intronic
chr3:150152138(+) A-I      intronic
chr3:150169761(+) A-I      intronic
chr3:150160549(+) A-I      intronic
chr3:150151803(+) A-I      intronic
chr3:150160591(+) A-I      intronic
chr3:150169682(+) A-I      intronic
chr3:150175522(+) A-I      intronic
chr3:150151726(+) A-I      intronic
chr3:150174158(+) A-I      intronic
chr3:150159450(+) A-I      intronic
chr3:150151997(+) A-I      intronic
chr3:150133479(+) A-I      intronic
chr3:150152069(+) A-I      intronic
chr3:150143232(+) A-I      intronic
chr3:150169745(+) A-I      intronic
chr3:150174112(+) A-I      intronic
chr3:150152010(+) A-I      intronic
chr3:150170121(+) A-I      intronic
chr3:150152094(+) A-I      intronic
chr3:150169777(+) A-I      intronic
chr3:150152095(+) A-I      intronic
chr3:150174074(+) A-I      intronic
chr3:150151647(+) A-I      intronic
chr3:150151819(+) A-I      intronic
chr3:150155401(+) A-I      intronic
chr3:150152151(+) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED TSC22D2
chr3:150171288(+) A-I intron -    21960545
chr3:150171313(+) A-I intron -    21960545
chr3:150143232(+) A-G intron -    22484847
chr3:150151647(+) A-G intron -    22484847
chr3:150151726(+) A-G intron -    22484847
chr3:150151733(+) A-G intron -    22484847
chr3:150151741(+) A-G intron -    22484847
chr3:150151803(+) A-G intron -    22484847
chr3:150151819(+) A-G intron -    22484847
chr3:150151997(+) A-G intron -    22484847
chr3:150152010(+) A-G intron -    22484847
chr3:150152016(+) A-G intron -    22484847
chr3:150152069(+) A-G intron -    22484847
chr3:150152071(+) A-G intron -    22484847
chr3:150152094(+) A-G intron -    22484847
chr3:150152113(+) A-G intron -    22484847
chr3:150152138(+) A-G intron -    22484847
chr3:150163624(+) T-G intron -    22484847
chr3:150169680(+) A-G intron -    22484847
chr3:150170138(+) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase TSC22D2
chr3:150126354-150126355(+) m6A 5'UTR       -
chr3:150126537-150126538(+) m6A 5'UTR       24209618
chr3:150126594-150126595(+) m6A 5'UTR       24209618
chr3:150126771-150126772(+) m6A 5'UTR       24284625//24209618//25456834//24981863//22575960//22608085
chr3:150126907-150126908(+) m6A 5'UTR       24284625//24209618//25456834//24981863//26404942//27773536//22575960//22608085
chr3:150126933-150126934(+) m6A 5'UTR       24284625//24209618//25456834//24981863//26404942//27773536//22575960//22608085
chr3:150127025-150127026(+) m6A 5'UTR       24284625//24209618//25456834//24981863//22575960//22608085
chr3:150127037-150127038(+) m6A 5'UTR       24284625//24209618//25456834//24981863//22575960//22608085
chr3:150127043-150127044(+) m6A 5'UTR       24284625//24209618//25456834//24981863//22575960//22608085
chr3:150127091-150127092(+) m6A 5'UTR       24284625//24209618//25456834//24981863//22575960//22608085
chr3:150127222-150127223(+) m6A CDS       24284625//25456834//24981863//22575960//22608085
chr3:150127374-150127375(+) m6A CDS       24284625//25456834//24981863//22575960//22608085
chr3:150127383-150127384(+) m6A CDS       24284625//25456834//24981863//22575960//22608085
chr3:150127396-150127397(+) m6A CDS       24284625//25456834//24981863//22575960//22608085
chr3:150127639-150127640(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr3:150127708-150127709(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr3:150127745-150127746(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr3:150127767-150127768(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr3:150127780-150127781(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr3:150127860-150127861(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085
chr3:150128099-150128100(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085
chr3:150128237-150128238(+) m6A CDS       24284625//24209618//24981863//22575960
chr3:150128462-150128463(+) m6A CDS       25456834//24981863//22608085
chr3:150128880-150128881(+) m6A CDS       24284625//24209618//24981863//26404942//27773535//22608085
chr3:150128886-150128887(+) m6A CDS       24284625//24209618//24981863//26404942//27773535//22608085
chr3:150128933-150128934(+) m6A CDS       24284625//24209618//24981863//26404942//27773535//22608085
chr3:150129013-150129014(+) m6A CDS       24284625//24209618//24981863//26404942//27773535//22608085
chr3:150129037-150129038(+) m6A CDS       24284625//24209618//24981863//26404942//27773535//22608085
chr3:150129091-150129092(+) m6A CDS       24284625//24209618//24981863//26404942//27773535//22608085
chr3:150140873-150140874(+) m6A CDS//exon//intron       24981863//26404942//27773535//22608085
chr3:150156100-150156101(+) m6A 3'UTR//intron       27773535
chr3:150174779-150174780(+) m6A exon//intron       -
chr3:150174904-150174905(+) m6A 3'UTR//CDS//exon//intron       24284625//24209618//24981863//27773535//22608085
chr3:150176221-150176222(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//26404942//27773535//22608085
chr3:150176247-150176248(+) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//26404942//27773535//22608085
chr3:150176451-150176452(+) m6A 3'UTR//exon       24284625//24209618//24981863//26404942//27773535//22608085
chr3:150176552-150176553(+) m6A 3'UTR//exon       22608085
chr3:150176897-150176898(+) m6A 3'UTR//exon       26404942
chr3:150176910-150176911(+) m6A 3'UTR//exon       26404942
chr3:150176961-150176962(+) m6A 3'UTR       26404942
chr3:150177004-150177005(+) m6A 3'UTR       26404942
chr3:150177543-150177544(+) m6A 3'UTR       26404942
chr3:150177567-150177568(+) m6A 3'UTR       26404942
chr3:150183794-150183795(+) m6A 3'UTR       22608085
chr3:150183819-150183820(+) m6A 3'UTR       22608085
chr3:150183901-150183902(+) m6A 3'UTR       22608085

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-146b-3p
Exosome Pulmonary epithelial cell line (BEAS-2B)     31520698
Exosome Plasma     23663360
Exosome Mast cells     -
Microvesicle Fibroblasts|Mesenchymal stem cells     -
TSC22D2
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Membrane K562 cells     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HeLa-S3 cells|K562 cells     -
Ribosome HEK-293 cells     22199352

Related Drug Information:


Resource Symbol Drug Name PubChem ID
RNAactDrug hsa-miR-146b-3p
l-685,458       5479543

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-146b-3p
Interactor2: TSC22D2

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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