Basic Information:

  VIRBase ID:  

HHID00066766

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-146b-3p:  MIMAT0004766          MAP3K10:  NM_002446     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-146b-3p	MAP3K10
miRBase Accession/Entrez ID	MIMAT0004766	4294
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	MEKK10//MLK2//MST

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-146b-3p	rs1367942461 chr10:102436557    G/A rs1467375133 chr10:102436569    C/A rs766852690 chr10:102436575    TGGTGCCC/T rs768018523 chr10:102436577    G/C rs1425832655 chr10:102436558    C/T rs944616447 chr10:102436564    G/A

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	MAP3K10	chr19:40715843(+) A-I      intronic chr19:40709071(+) A-I      intronic chr19:40706108(+) A-I      intronic chr19:40704890(+) A-I      intronic chr19:40713428(+) A-I      intronic chr19:40713433(+) A-I      intronic chr19:40713442(+) A-I      intronic chr19:40707499(+) A-I      intronic chr19:40715886(+) A-I      intronic chr19:40715840(+) A-I      intronic chr19:40709091(+) A-I      intronic chr19:40706029(+) A-I      intronic chr19:40715449(+) A-I      intronic chr19:40714563(+) A-I      intronic chr19:40714386(+) A-I      intronic chr19:40714325(+) A-I      intronic chr19:40714310(+) A-I      intronic chr19:40714208(+) A-I      intronic chr19:40714206(+) A-I      intronic chr19:40714159(+) A-I      intronic chr19:40714098(+) A-I      intronic chr19:40713538(+) A-I      intronic chr19:40715519(+) A-I      intronic chr19:40717832(+) A-I      intronic chr19:40717811(+) A-I      intronic chr19:40717760(+) A-I      intronic chr19:40716053(+) A-I      intronic chr19:40715504(+) A-I      intronic chr19:40706726(+) A-I      intronic chr19:40713535(+) A-I      intronic chr19:40713531(+) A-I      intronic chr19:40712933(+) A-I      intronic chr19:40713522(+) A-I      intronic chr19:40713521(+) A-I      intronic chr19:40713513(+) A-I      intronic chr19:40700058(+) A-I      intronic chr19:40704788(+) A-I      intronic chr19:40704789(+) A-I      intronic chr19:40704804(+) A-I      intronic chr19:40704916(+) A-I      intronic chr19:40704934(+) A-I      intronic chr19:40705889(+) A-I      intronic chr19:40705955(+) A-I      intronic chr19:40705963(+) A-I      intronic chr19:40705982(+) A-I      intronic chr19:40706035(+) A-I      intronic chr19:40713457(+) A-I      intronic chr19:40712966(+) A-I      intronic chr19:40712435(+) A-I      intronic chr19:40709187(+) A-I      intronic chr19:40708154(+) A-I      intronic chr19:40708146(+) A-I      intronic chr19:40708123(+) A-I      intronic chr19:40708114(+) A-I      intronic chr19:40707526(+) A-I      intronic chr19:40707420(+) A-I      intronic chr19:40707311(+) A-I      intronic chr19:40707289(+) A-I      intronic chr19:40707287(+) A-I      intronic chr19:40707184(+) A-I      intronic chr19:40706800(+) A-I      intronic chr19:40706751(+) A-I      intronic chr19:40715502(+) A-I      intronic chr19:40706590(+) A-I      intronic chr19:40706589(+) A-I      intronic chr19:40706569(+) A-I      intronic chr19:40706131(+) A-I      intronic chr19:40706138(+) A-I      intronic chr19:40706549(+) A-I      intronic chr19:40715946(+) A-I      intronic chr19:40715879(+) A-I      intronic chr19:40715853(+) A-I      intronic chr19:40715832(+) A-I      intronic chr19:40715824(+) A-I      intronic chr19:40715807(+) A-I      intronic chr19:40715556(+) A-I      intronic chr19:40715522(+) A-I      intronic chr19:40707133(+) A-I      intronic chr19:40714536(+) A-I      intronic chr19:40707187(+) A-I      intronic chr19:40706178(+) A-I      intronic chr19:40706791(+) A-I      intronic chr19:40707285(+) A-I      intronic chr19:40706020(+) A-I      intronic chr19:40713909(+) A-I      intronic chr19:40716084(+) A-I      intronic chr19:40709020(+) A-I      intronic chr19:40708017(+) A-I      intronic chr19:40714383(+) A-I      intronic chr19:40716063(+) A-I      intronic chr19:40701519(+) A-I      intronic chr19:40708601(+) A-I      intronic chr19:40706010(+) A-I      intronic chr19:40706582(+) A-I      intronic chr19:40715343(+) A-I      intronic chr19:40706557(+) A-I      intronic chr19:40707529(+) A-I      intronic chr19:40704720(+) A-I      intronic chr19:40713418(+) A-I      intronic chr19:40705811(+) A-I      intronic chr19:40707374(+) A-I      intronic chr19:40705904(+) A-I      intronic chr19:40708209(+) A-I      intronic chr19:40709172(+) A-I      intronic chr19:40705827(+) A-I      intronic chr19:40706044(+) A-I      intronic chr19:40716446(+) A-I      intronic chr19:40709060(+) A-I      intronic chr19:40706706(+) A-I      intronic chr19:40714535(+) A-I      intronic chr19:40705870(+) A-I      intronic chr19:40709135(+) A-I      intronic chr19:40707517(+) A-I      intronic chr19:40702506(+) A-I      intronic chr19:40715596(+) A-I      intronic chr19:40707479(+) A-I      intronic chr19:40709216(+) A-I      intronic chr19:40715557(+) A-I      intronic chr19:40705915(+) A-I      intronic chr19:40704871(+) A-I      intronic chr19:40704864(+) A-I      intronic chr19:40704907(+) A-I      intronic chr19:40706059(+) A-I      intronic chr19:40704895(+) A-I      intronic chr19:40704828(+) A-I      intronic chr19:40704713(+) A-I      intronic chr19:40707183(+) A-I      intronic chr19:40708616(+) A-I      intronic chr19:40708028(+) A-I      intronic chr19:40709245(+) A-I      intronic chr19:40715485(+) A-I      intronic chr19:40709051(+) A-I      intronic chr19:40706183(+) A-I      intronic chr19:40707580(+) A-I      intronic chr19:40707362(+) A-I      intronic chr19:40706166(+) A-I      intronic chr19:40713410(+) A-I      intronic chr19:40707347(+) A-I      intronic chr19:40713820(+) A-I      intronic chr19:40707361(+) A-I      intronic chr19:40707545(+) A-I      intronic chr19:40717797(+) A-I      intronic chr19:40717770(+) A-I      intronic chr19:40709201(+) A-I      intronic chr19:40705924(+) A-I      intronic chr19:40706769(+) A-I      intronic chr19:40705627(+) A-I      intronic chr19:40709125(+) A-I      intronic chr19:40714489(+) A-I      intronic chr19:40715829(+) A-I      intronic chr19:40706626(+) A-I      intronic chr19:40709126(+) A-I      intronic chr19:40707573(+) A-I      intronic chr19:40712219(+) A-I      intronic chr19:40713365(+) A-I      intronic chr19:40705656(+) A-I      intronic chr19:40705833(+) A-I      intronic chr19:40715384(+) A-I      intronic chr19:40707979(+) A-I      intronic chr19:40708993(+) A-I      intronic chr19:40706030(+) A-I      intronic chr19:40705655(+) A-I      intronic chr19:40707209(+) A-I      intronic chr19:40704881(+) A-I      intronic chr19:40712934(+) A-I      intronic chr19:40715569(+) A-I      intronic chr19:40717814(+) A-I      intronic chr19:40712745(+) A-I      intronic chr19:40715856(+) A-I      intronic chr19:40706643(+) A-I      intronic chr19:40707967(+) A-I      intronic chr19:40704980(+) A-I      intronic chr19:40701557(+) A-I      intronic chr19:40708012(+) A-I      intronic chr19:40705810(+) A-I      intronic chr19:40706793(+) A-I      intronic chr19:40708994(+) A-I      intronic chr19:40707304(+) A-I      intronic chr19:40712816(+) A-I      intronic chr19:40712971(+) A-I      intronic chr19:40715857(+) A-I      intronic chr19:40709100(+) A-I      intronic chr19:40715771(+) A-I      intronic chr19:40716176(+) A-I      intronic chr19:40708977(+) A-I      intronic chr19:40716487(+) A-I      intronic chr19:40707500(+) A-I      intronic chr19:40701530(+) A-I      intronic chr19:40705631(+) A-I      intronic chr19:40715420(+) A-I      intronic chr19:40715584(+) A-I      intronic chr19:40712746(+) A-I      intronic chr19:40702688(+) A-I      intronic chr19:40715920(+) A-I      intronic chr19:40709155(+) A-I      intronic chr19:40706655(+) A-I      intronic chr19:40707625(+) A-I      intronic chr19:40712886(+) A-I      intronic chr19:40706691(+) A-I      intronic chr19:40705947(+) A-I      intronic chr19:40707486(+) A-I      intronic chr19:40712203(+) A-I      intronic chr19:40706099(+) A-I      intronic chr19:40709196(+) A-I      intronic chr19:40706022(+) A-I      intronic chr19:40714543(+) A-I      intronic chr19:40709076(+) A-I      intronic chr19:40714365(+) A-I      intronic chr19:40713630(+) A-I      intronic chr19:40706184(+) A-I      intronic chr19:40712915(+) A-I      intronic chr19:40706112(+) A-I      intronic chr19:40712737(+) A-I      intronic chr19:40717687(+) A-I      intronic chr19:40704844(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	MAP3K10	chr19:40706099(+) A-G intron -    22484847 chr19:40707479(+) A-G intron -    22484847 chr19:40708977(+) A-G intron -    22484847 chr19:40709125(+) A-G intron -    22484847 chr19:40709126(+) A-G intron -    22484847 chr19:40709201(+) A-G intron -    22484847 chr19:40712885(+) A-G intron -    22484847 chr19:40712886(+) A-G intron -    22484847 chr19:40714471(+) A-G intron -    22484847 chr19:40714489(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	MAP3K10	chr19:40697699-40697700(+) m6A 5'UTR       - chr19:40697835-40697836(+) m6A 5'UTR       24209618//25456834//24981863//22608085 chr19:40697846-40697847(+) m6A 5'UTR       24209618//25456834//24981863//22608085 chr19:40698001-40698002(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr19:40698083-40698084(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr19:40698115-40698116(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr19:40698326-40698327(+) m6A CDS//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr19:40698338-40698339(+) m6A CDS//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr19:40698560-40698561(+) m6A CDS//exon       24284625//25456834//24981863 chr19:40698602-40698603(+) m6A CDS//exon       24284625//25456834//24981863 chr19:40704305-40704306(+) m6A CDS//exon       24284625//25456834//24981863 chr19:40704320-40704321(+) m6A CDS//exon       24284625//25456834//24981863 chr19:40704341-40704342(+) m6A CDS//exon       24284625//25456834//24981863 chr19:40704370-40704371(+) m6A CDS//exon       24284625//24981863 chr19:40704394-40704395(+) m6A CDS//exon       24284625//24981863 chr19:40711097-40711098(+) m6A 3'UTR//CDS//exon       24284625 chr19:40711150-40711151(+) m6A 3'UTR//CDS//exon       24284625 chr19:40711191-40711192(+) m6A 3'UTR//CDS//exon       24284625 chr19:40711923-40711924(+) m6A 3'UTR//CDS//exon//intron       24284625//24209618//24981863 chr19:40718723-40718724(+) m6A 3'UTR//CDS//exon       24284625//25456834//24981863 chr19:40718767-40718768(+) m6A 3'UTR//CDS//exon       24284625//25456834//24981863 chr19:40718802-40718803(+) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863 chr19:40718821-40718822(+) m1A 3'UTR//CDS//exon       26863196 chr19:40719009-40719010(+) m6A 3'UTR//CDS//exon       24284625//25456834//24981863 chr19:40719051-40719052(+) m6A 3'UTR//CDS//exon       24284625//25456834//24981863 chr19:40719171-40719172(+) m6A exon//intron       24284625 chr19:40719262-40719263(+) m6A exon//intron       - chr19:40719291-40719292(+) m6A exon//intron       - chr19:40719972-40719973(+) m6A 3'UTR//CDS       24981863 chr19:40719999-40720000(+) m6A 3'UTR//CDS       - chr19:40720894-40720895(+) m6A 3'UTR//CDS       24284625//24209618//25456834 chr19:40720991-40720992(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr19:40721023-40721024(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr19:40721033-40721034(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr19:40721052-40721053(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr19:40721083-40721084(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr19:40721131-40721132(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr19:40721137-40721138(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr19:40721152-40721153(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr19:40721158-40721159(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr19:40721336-40721337(+) m6A 3'UTR       - chr19:40721422-40721423(+) m6A 3'UTR       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-146b-3p	Exosome Pulmonary epithelial cell line (BEAS-2B)     31520698 Exosome Plasma     23663360 Exosome Mast cells     - Microvesicle Fibroblasts|Mesenchymal stem cells     -
	MAP3K10	Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Membrane HCC cell line (HepG2)     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HeLa-S3 cells     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	hsa-miR-146b-3p	l-685,458       5479543

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-146b-3p
Interactor2: MAP3K10

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.