Basic Information:

  VIRBase ID:  

HHID00066764

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-146b-3p:  MIMAT0004766          B4GALT1:  NM_001378495     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-146b-3p	B4GALT1
miRBase Accession/Entrez ID	MIMAT0004766	2683
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	B4GAL-T1//beta4Gal-T1//CDG2D//GGTB2//GT1//GTB

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-146b-3p	rs1367942461 chr10:102436557    G/A rs1467375133 chr10:102436569    C/A rs766852690 chr10:102436575    TGGTGCCC/T rs768018523 chr10:102436577    G/C rs1425832655 chr10:102436558    C/T rs944616447 chr10:102436564    G/A

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	B4GALT1	chr9:33149441(-) A-I      intronic chr9:33148033(-) A-I      intronic chr9:33146794(-) A-I      intronic chr9:33146784(-) A-I      intronic chr9:33144412(-) A-I      intronic chr9:33144411(-) A-I      intronic chr9:33144397(-) A-I      intronic chr9:33144361(-) A-I      intronic chr9:33143081(-) A-I      intronic chr9:33143005(-) A-I      intronic chr9:33142979(-) A-I      intronic chr9:33142926(-) A-I      intronic chr9:33142650(-) A-I      intronic chr9:33142144(-) A-I      intronic chr9:33142078(-) A-I      intronic chr9:33142077(-) A-I      intronic chr9:33142073(-) A-I      intronic chr9:33141433(-) A-I      intronic chr9:33123136(-) A-I      intronic chr9:33123132(-) A-I      intronic chr9:33123020(-) A-I      intronic chr9:33118573(-) A-I      intronic chr9:33118546(-) A-I      intronic chr9:33116785(-) A-I      intronic chr9:33116758(-) A-I      intronic chr9:33116714(-) A-I      intronic chr9:33116634(-) A-I      intronic chr9:33119498(-) A-I      intronic chr9:33119124(-) A-I      intronic chr9:33119092(-) A-I      intronic chr9:33119087(-) A-I      intronic chr9:33119523(-) A-I      intronic chr9:33119053(-) A-I      intronic chr9:33119024(-) A-I      intronic chr9:33122404(-) A-I      intronic chr9:33122336(-) A-I      intronic chr9:33122244(-) A-I      intronic chr9:33119020(-) A-I      intronic chr9:33118998(-) A-I      intronic chr9:33118980(-) A-I      intronic chr9:33118975(-) A-I      intronic chr9:33118675(-) A-I      intronic chr9:33160754(-) A-I      intronic chr9:33160548(-) A-I      intronic chr9:33165068(-) A-I      intronic chr9:33165076(-) A-I      intronic chr9:33165082(-) A-I      intronic chr9:33165095(-) A-I      intronic chr9:33160547(-) A-I      intronic chr9:33121595(-) A-I      intronic chr9:33120056(-) A-I      intronic chr9:33120054(-) A-I      intronic chr9:33119672(-) A-I      intronic chr9:33119602(-) A-I      intronic chr9:33119566(-) A-I      intronic chr9:33119558(-) A-I      intronic chr9:33149569(-) A-I      intronic chr9:33149500(-) A-I      intronic chr9:33149455(-) A-I      intronic chr9:33149448(-) A-I      intronic chr9:33149444(-) A-I      intronic chr9:33119480(-) A-I      intronic chr9:33147866(-) A-I      intronic chr9:33160633(-) A-I      intronic chr9:33119592(-) A-I      intronic chr9:33122342(-) A-I      intronic chr9:33142744(-) A-I      intronic chr9:33165067(-) A-I      intronic chr9:33118997(-) A-I      intronic chr9:33122294(-) A-I      intronic chr9:33149417(-) A-I      intronic chr9:33116306(-) A-I      intronic chr9:33116326(-) A-I      intronic chr9:33141354(-) A-I      intronic chr9:33141336(-) A-I      intronic chr9:33141476(-) A-I      intronic chr9:33121458(-) A-I      intronic chr9:33141321(-) A-I      intronic chr9:33116368(-) A-I      intronic chr9:33120057(-) A-I      intronic chr9:33119657(-) A-I      intronic chr9:33141268(-) A-I      intronic chr9:33133033(-) A-I      intronic chr9:33143963(-) A-I      intronic chr9:33143060(-) A-I      intronic chr9:33119620(-) A-I      intronic chr9:33122266(-) A-I      intronic chr9:33147321(-) A-I      intronic chr9:33143031(-) A-I      intronic chr9:33133128(-) A-I      intronic chr9:33144487(-) A-I      intronic chr9:33121635(-) A-I      intronic chr9:33121428(-) A-I      intronic chr9:33133168(-) A-I      intronic chr9:33146877(-) A-I      intronic chr9:33122260(-) A-I      intronic chr9:33120060(-) A-I      intronic chr9:33121477(-) A-I      intronic chr9:33120135(-) A-I      intronic chr9:33133151(-) A-I      intronic chr9:33121446(-) A-I      intronic chr9:33144371(-) A-I      intronic chr9:33147813(-) A-I      intronic chr9:33118932(-) A-I      intronic chr9:33118401(-) A-I      intronic chr9:33120073(-) A-I      intronic chr9:33120087(-) A-I      intronic chr9:33121618(-) A-I      intronic chr9:33143112(-) A-I      intronic chr9:33122422(-) A-I      intronic chr9:33142715(-) A-I      intronic chr9:33152110(-) A-I      intronic chr9:33141432(-) A-I      intronic chr9:33116302(-) A-I      intronic chr9:33119133(-) A-I      intronic chr9:33143067(-) A-I      intronic chr9:33121391(-) A-I      intronic chr9:33119132(-) A-I      intronic chr9:33123026(-) A-I      intronic chr9:33120125(-) A-I      intronic chr9:33118440(-) A-I      intronic chr9:33119965(-) A-I      intronic chr9:33119565(-) A-I      intronic chr9:33120082(-) A-I      intronic chr9:33144098(-) A-I      intronic chr9:33119522(-) A-I      intronic chr9:33149491(-) A-I      intronic chr9:33119097(-) A-I      intronic chr9:33141338(-) A-I      intronic chr9:33127228(-) A-I      intronic chr9:33120120(-) A-I      intronic chr9:33120070(-) A-I      intronic chr9:33142692(-) A-I      intronic chr9:33147937(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	B4GALT1	chr9:33119570(-) A-I intron -    21960545 chr9:33126631(-) A-I intron -    21960545 chr9:33148033(-) A-I intron -    21960545 chr9:33116368(-) A-G intron -    22484847 chr9:33116378(-) A-G intron -    22484847 chr9:33119965(-) A-G intron -    22484847 chr9:33122266(-) A-G intron -    22484847 chr9:33122409(-) A-G intron -    22484847 chr9:33133168(-) A-G intron -    22484847 chr9:33141321(-) A-G intron -    22484847 chr9:33141439(-) A-G intron -    22484847 chr9:33149417(-) A-G intron -    22484847 chr9:33149491(-) A-G intron -    22484847 chr9:33165067(-) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	B4GALT1	chr9:33104348-33104349(-) m6A 3'UTR       - chr9:33104412-33104413(-) m6A 3'UTR       - chr9:33104431-33104432(-) m6A 3'UTR       - chr9:33110930-33110931(-) Am 3'UTR//intron       - chr9:33111204-33111205(-) m6A 3'UTR//intron       26404942 chr9:33111294-33111295(-) m6A 3'UTR//intron       26404942 chr9:33111299-33111300(-) m6A 3'UTR//intron       26404942 chr9:33111343-33111344(-) m6A 3'UTR//intron       26404942 chr9:33111450-33111451(-) m6A 3'UTR//intron       26404942 chr9:33111508-33111509(-) m6A 3'UTR//intron       26404942 chr9:33111923-33111924(-) m6A 3'UTR//intron       27773535 chr9:33111949-33111950(-) m6A 3'UTR//intron       27773535 chr9:33112015-33112016(-) m6A 3'UTR//intron       27773535 chr9:33112040-33112041(-) m6A 3'UTR//intron       27773535 chr9:33112567-33112568(-) Y 3'UTR//intron       25219674 chr9:33112606-33112607(-) m6A 3'UTR//intron       26404942 chr9:33113003-33113004(-) m6A 3'UTR//intron       24284625//26404942 chr9:33113152-33113153(-) m6A 3'UTR//intron       24284625//24981863//26404942 chr9:33113185-33113186(-) m6A 3'UTR//intron       24284625//24981863//26404942 chr9:33113410-33113411(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//28052920//26404942//22575960//22608085 chr9:33113428-33113429(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//28052920//26404942//27371828//22575960//22608085 chr9:33113462-33113463(-) m6A CDS//intron       24284625//24209618//25456834//24981863//28052920//26404942//27371828//22575960//22608085 chr9:33113470-33113471(-) m6A CDS//intron       24284625//24209618//25456834//24981863//28052920//26404942//27371828//22575960//22608085 chr9:33113533-33113534(-) m6A CDS//intron       24284625//24209618//25456834//24981863//28052920//26404942//22575960//22608085 chr9:33113555-33113556(-) m6A CDS//intron       24284625//24209618//25456834//24981863//28052920//26404942//22575960//22608085 chr9:33113785-33113786(-) m6A CDS//intron       24284625//24209618//24981863//26404942//22608085 chr9:33113798-33113799(-) m6A CDS//intron       24284625//24209618//24981863//26404942//22608085 chr9:33116065-33116066(-) m6A CDS//intron       26404942 chr9:33135211-33135212(-) m6A CDS       26404942//27773535 chr9:33135322-33135323(-) m6A CDS       26404942 chr9:33135361-33135362(-) m6A CDS       - chr9:33135385-33135386(-) m6A CDS       22575960 chr9:33166932-33166933(-) m6A CDS       24284625//27773536//22575960 chr9:33166973-33166974(-) m6A CDS       24284625//27773536//22575960

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-146b-3p	Exosome Pulmonary epithelial cell line (BEAS-2B)     31520698 Exosome Plasma     23663360 Exosome Mast cells     - Microvesicle Fibroblasts|Mesenchymal stem cells     -
	B4GALT1	Chromatin K562 cells     - Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleoplasm K562 cells     - Nucleus HeLa-S3 cells|K562 cells     - Ribosome HEK-293 cells     22199352

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	hsa-miR-146b-3p	l-685,458       5479543

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-146b-3p
Interactor2: B4GALT1

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.