Basic Information:

  VIRBase ID:  

HHID00066716

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-20b-3p:  MIMAT0004752          ZNF770:  NM_014106     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-20b-3p	ZNF770
miRBase Accession/Entrez ID	MIMAT0004752	54989
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	PRO1914

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-20b-3p	rs1447596630 chrX:134169823    C/A rs1447596630 chrX:134169823    C/G rs756043449 chrX:134169822    C/G rs756043449 chrX:134169822    C/T rs766220784 chrX:134169828    C/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	ZNF770	chr15:35272815(-) A-I      3'UTR chr15:35272821(-) A-I      3'UTR chr15:35272786(-) A-I      3'UTR chr15:35272812(-) A-I      3'UTR chr15:35272794(-) A-I      3'UTR chr15:35272969(-) A-I      3'UTR

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ZNF770	chr15:35270763-35270764(-) m6A 3'UTR       27773535 chr15:35271583-35271584(-) m6A 3'UTR       24981863 chr15:35271594-35271595(-) m6A 3'UTR       24981863 chr15:35271674-35271675(-) m6A 3'UTR       24981863 chr15:35274013-35274014(-) m6A CDS       22608085 chr15:35274069-35274070(-) m6A CDS       22608085 chr15:35274075-35274076(-) m6A CDS       22608085 chr15:35274096-35274097(-) m6A CDS       22608085 chr15:35274138-35274139(-) m6A CDS       22608085 chr15:35274159-35274160(-) m6A CDS       22608085 chr15:35274168-35274169(-) m6A CDS       22608085 chr15:35274222-35274223(-) m6A CDS       22608085 chr15:35274235-35274236(-) m6A CDS       22608085 chr15:35274319-35274320(-) m6A CDS       24981863//22608085 chr15:35274355-35274356(-) m6A CDS       24284625//24981863//27773535//22608085 chr15:35274422-35274423(-) m6A CDS       24284625//24981863//27773535//22608085 chr15:35274446-35274447(-) m6A CDS       24284625//24981863//27773535//27371828//22608085 chr15:35274455-35274456(-) m6A CDS       24284625//24981863//27773535//27371828//22608085 chr15:35274462-35274463(-) m6A CDS       24284625//24981863//27773535//27371828//22608085 chr15:35274485-35274486(-) m6A CDS       24284625//24981863//27773535//22608085 chr15:35274498-35274499(-) m6A CDS       24284625//24981863//27773535//22608085 chr15:35274635-35274636(-) m6A CDS       24981863 chr15:35274930-35274931(-) m6A CDS       24284625//24981863//27773535//22608085 chr15:35274945-35274946(-) m6A CDS       24284625//24981863//27773535//22575960//22608085 chr15:35274993-35274994(-) m6A CDS       24284625//24981863//28052920//27773535//22575960//22608085 chr15:35275113-35275114(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085 chr15:35275299-35275300(-) m6A CDS       24284625//24209618//24981863//28052920//27773535//27371828//22575960//22608085 chr15:35275319-35275320(-) m6A CDS       24284625//24209618//24981863//28052920//27773535//27371828//22575960//22608085 chr15:35275352-35275353(-) m6A CDS       24284625//24981863//28052920//27773535//22575960//22608085 chr15:35275440-35275441(-) m6A CDS       24284625//24981863//27773535//22575960//22608085 chr15:35275448-35275449(-) m6A CDS       24284625//24981863//27773535//22575960//22608085 chr15:35275523-35275524(-) m6A CDS       24284625//24981863//27773535//22608085 chr15:35275564-35275565(-) m6A CDS       24284625//24981863//27773535//22608085 chr15:35275575-35275576(-) m6A CDS       24284625//24981863//27773535//22608085 chr15:35275621-35275622(-) m6A CDS       24284625//24981863//27773535//22608085 chr15:35275671-35275672(-) m6A 5'UTR       24284625//24981863//27773535//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-20b-3p	Exosome Human mast cell line (HMC-1)     24009880 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Seminal plasma     23539611 Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     - Mitochondrion Cell line (HEK-293)     22984580
	ZNF770	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleoplasm K562 cells     - Nucleus HeLa-S3 cells     - Ribosome Colon cancer cells     24393600

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-20b-3p	Temozolomide 5394       31053733

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-20b-3p
Interactor2: ZNF770

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.