Basic Information:

  VIRBase ID:  

HHID00066626

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-335-3p:  MIMAT0004703          CDKN1B:  NM_004064     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-335-3p	CDKN1B
miRBase Accession/Entrez ID	MIMAT0004703	1027
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	CDKN4//KIP1//MEN1B//MEN4//P27KIP1

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-335-3p	rs1554436919 chr7:130496173    T/C rs1554436922 chr7:130496183    C/G rs781884324 chr7:130496177    C/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	CDKN1B	chr12:12868290(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	CDKN1B	chr12:12870457-12870458(+) m6A 5'UTR//intron       24284625//24981863//22575960//22608085 chr12:12870481-12870482(+) m6A 5'UTR//intron       24284625//24981863//22575960//22608085 chr12:12870568-12870569(+) m6A 5'UTR//intron       - chr12:12870760-12870761(+) m6A 5'UTR//intron       24209618//24981863//22608085 chr12:12870864-12870865(+) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr12:12870882-12870883(+) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr12:12870903-12870904(+) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr12:12870921-12870922(+) Gm CDS//intron       - chr12:12870924-12870925(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085 chr12:12870976-12870977(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr12:12871042-12871043(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr12:12871152-12871153(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr12:12871167-12871168(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr12:12871175-12871176(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr12:12871188-12871189(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr12:12871773-12871774(+) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr12:12871790-12871791(+) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr12:12871880-12871881(+) m6A 3'UTR//exon//intron       24284625//24981863//22608085 chr12:12874075-12874076(+) m6A 3'UTR//CDS//exon       24284625//24981863//26404942//22608085 chr12:12874098-12874099(+) m6A 3'UTR//CDS//exon       24284625//24981863//26404942//27773535//22608085 chr12:12874247-12874248(+) m6A 3'UTR       24981863//22608085 chr12:12874282-12874283(+) m6A 3'UTR       24981863 chr12:12875101-12875102(+) m6A 3'UTR       27773535 chr12:12875290-12875291(+) m6A 3'UTR       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-335-3p	Exosome Breast milk     22211110 Exosome Plasma     23663360 Exosome Serum     24683445 Exosome Breast milk|Endothelial cells     - Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
	CDKN1B	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Ribosome HEK-293 cells     22199352 Ribosome Colon cancer cells     24393600

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-335-3p	10-Hydroxycamptothecin 97226 Drug interaction    RC00007108 Naringin 442428 Drug interaction    RC00007110 Proanthocyanidin 108065 Drug interaction    RC00007109

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-335-3p	Cisplatin 5702198       21575166 Tamoxifen 2733526       28008602 N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719       26456124

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-335-3p
Interactor2: CDKN1B

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.