Basic Information:

  VIRBase ID:  

HHID00066615

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-331-5p:  MIMAT0004700          PACRGL:  NR_133933     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-331-5p	PACRGL
miRBase Accession/Entrez ID	MIMAT0004700	133015
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	C4orf28

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-331-5p	rs1022284453 chr12:95308457    C/T rs1348663338 chr12:95308458    C/T rs1441645779 chr12:95308445    C/G rs779887738 chr12:95308455    T/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	PACRGL	chr4:20711390(+) A-I      Syn:Leu->Leu chr4:20718091(+) A-I      intronic chr4:20718086(+) A-I      intronic chr4:20708262(+) A-I      intronic chr4:20710642(+) A-I      intronic chr4:20708338(+) A-I      intronic chr4:20708404(+) A-I      intronic chr4:20729484(+) A-I      3'UTR chr4:20729479(+) A-I      3'UTR chr4:20710658(+) A-I      intronic chr4:20710682(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	PACRGL	chr4:20702227-20702228(+) m6A 5'UTR//exon//intron       - chr4:20702302-20702303(+) m6A 5'UTR//exon//intron       - chr4:20706144-20706145(+) m6A CDS       24981863 chr4:20706299-20706300(+) m6A CDS       24981863 chr4:20706322-20706323(+) m6A CDS       24981863 chr4:20706388-20706389(+) m6A CDS       24981863 chr4:20706400-20706401(+) m6A CDS       24981863 chr4:20754322-20754323(+) m6A 3'UTR       25456834//24981863//27773535//22608085 chr4:20754417-20754418(+) m6A 3'UTR       25456834//24981863//27773535//22608085 chr4:20754442-20754443(+) m6A 3'UTR       25456834//24981863//27773535//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-331-5p	Exosome Plasma     23663360 Exosome Colon cancer cell line (LIM1863)     25330373 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
	PACRGL	Chromatin K562 cells     - Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)|K562 cells     - Exosome Blood     - Membrane K562 cells     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus HCC cell line (HepG2)|HeLa-S3 cells     - Ribosome Colon cancer cells     24393600

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-331-5p	Atorvastatin 60823 Drug interaction    RC00007103

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-331-5p	Doxorubicin 31703       21070600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-331-5p
Interactor2: PACRGL

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.