Basic Information:

  VIRBase ID:  

HHID00066555

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-148b-5p:  MIMAT0004699          DYRK1A:  NM_001396     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-148b-5p	DYRK1A
miRBase Accession/Entrez ID	MIMAT0004699	1859
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	DYRK//DYRK1//HP86//MNB//MNBH//MRD7

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-148b-5p	rs1163646382 chr12:54337253    C/G rs1340052632 chr12:54337255    C/T rs1354700810 chr12:54337257    C/G rs1403027445 chr12:54337251    T/C rs774342221 chr12:54337241    A/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	DYRK1A	chr21:38750658(+) A-I      intronic chr21:38748540(+) A-I      intronic chr21:38773968(+) A-I      intronic chr21:38775194(+) A-I      intronic chr21:38750675(+) A-I      intronic chr21:38750676(+) A-I      intronic chr21:38778743(+) A-I      intronic chr21:38778748(+) A-I      intronic chr21:38748745(+) A-I      intronic chr21:38748752(+) A-I      intronic chr21:38749551(+) A-I      intronic chr21:38749683(+) A-I      intronic chr21:38749883(+) A-I      intronic chr21:38749888(+) A-I      intronic chr21:38749900(+) A-I      intronic chr21:38749905(+) A-I      intronic chr21:38773169(+) A-I      intronic chr21:38773250(+) A-I      intronic chr21:38773265(+) A-I      intronic chr21:38773286(+) A-I      intronic chr21:38773292(+) A-I      intronic chr21:38773296(+) A-I      intronic chr21:38773319(+) A-I      intronic chr21:38773335(+) A-I      intronic chr21:38773342(+) A-I      intronic chr21:38775121(+) A-I      intronic chr21:38775129(+) A-I      intronic chr21:38775158(+) A-I      intronic chr21:38775249(+) A-I      intronic chr21:38778734(+) A-I      intronic chr21:38778839(+) A-I      intronic chr21:38778841(+) A-I      intronic chr21:38778913(+) A-I      intronic chr21:38783501(+) A-I      intronic chr21:38783538(+) A-I      intronic chr21:38783564(+) A-I      intronic chr21:38783610(+) A-I      intronic chr21:38789743(+) A-I      intronic chr21:38840475(+) A-I      intronic chr21:38840483(+) A-I      intronic chr21:38840513(+) A-I      intronic chr21:38853907(+) A-I      intronic chr21:38854040(+) A-I      intronic chr21:38854044(+) A-I      intronic chr21:38854053(+) A-I      intronic chr21:38866339(+) A-I      intronic chr21:38866428(+) A-I      intronic chr21:38866429(+) A-I      intronic chr21:38866468(+) A-I      intronic chr21:38799679(+) A-I      intronic chr21:38744696(+) A-I      intronic chr21:38747932(+) A-I      intronic chr21:38748026(+) A-I      intronic chr21:38748038(+) A-I      intronic chr21:38748713(+) A-I      intronic chr21:38782942(+) A-I      5'UTR chr21:38799700(+) A-I      intronic chr21:38773293(+) A-I      intronic chr21:38762359(+) A-I      intronic chr21:38854088(+) A-I      intronic chr21:38839753(+) A-I      intronic chr21:38778769(+) A-I      intronic chr21:38748646(+) A-I      intronic chr21:38750557(+) A-I      intronic chr21:38773914(+) A-I      intronic chr21:38748668(+) A-I      intronic chr21:38773295(+) A-I      intronic chr21:38799688(+) A-I      intronic chr21:38746908(+) A-I      intronic chr21:38749660(+) A-I      intronic chr21:38750588(+) A-I      intronic chr21:38798957(+) A-I      intronic chr21:38783230(+) A-I      intronic chr21:38799547(+) A-I      intronic chr21:38839581(+) A-I      intronic chr21:38748626(+) A-I      intronic chr21:38782866(+) A-I      intronic chr21:38748562(+) A-I      intronic chr21:38867018(+) A-I      intronic chr21:38749561(+) A-I      intronic chr21:38748690(+) A-I      intronic chr21:38840646(+) A-I      intronic chr21:38839742(+) A-I      intronic chr21:38840526(+) A-I      intronic chr21:38782858(+) A-I      intronic chr21:38748723(+) A-I      intronic chr21:38747891(+) A-I      intronic chr21:38750714(+) A-I      intronic chr21:38842325(+) A-I      intronic chr21:38782907(+) A-I      5'UTR chr21:38782930(+) A-I      5'UTR chr21:38782969(+) A-I      5'UTR chr21:38782959(+) A-I      5'UTR chr21:38782947(+) A-I      5'UTR chr21:38748732(+) A-I      intronic chr21:38775211(+) A-I      intronic chr21:38749871(+) A-I      intronic chr21:38825289(+) A-I      intronic chr21:38747020(+) A-I      intronic chr21:38749587(+) A-I      intronic chr21:38749682(+) A-I      intronic chr21:38866988(+) A-I      intronic chr21:38750825(+) A-I      intronic chr21:38748640(+) A-I      intronic chr21:38748557(+) A-I      intronic chr21:38799432(+) A-I      intronic chr21:38748085(+) A-I      intronic chr21:38750674(+) A-I      intronic chr21:38750670(+) A-I      intronic chr21:38749486(+) A-I      intronic chr21:38749539(+) A-I      intronic chr21:38866470(+) A-I      intronic chr21:38838089(+) A-I      intronic chr21:38825292(+) A-I      intronic chr21:38744639(+) A-I      intronic chr21:38744629(+) A-I      intronic chr21:38750790(+) A-I      intronic chr21:38799433(+) A-I      intronic chr21:38747945(+) A-I      intronic chr21:38750779(+) A-I      intronic chr21:38783243(+) A-I      intronic chr21:38789554(+) A-I      intronic chr21:38783599(+) A-I      intronic chr21:38750740(+) A-I      intronic chr21:38839754(+) A-I      intronic chr21:38783535(+) A-I      intronic chr21:38778735(+) A-I      intronic chr21:38787896(+) A-I      intronic chr21:38744665(+) A-I      intronic chr21:38799543(+) A-I      intronic chr21:38854046(+) A-I      intronic chr21:38747993(+) A-I      intronic chr21:38783405(+) A-I      intronic chr21:38866359(+) A-I      intronic chr21:38749534(+) A-I      intronic chr21:38773841(+) A-I      intronic chr21:38749845(+) A-I      intronic chr21:38778778(+) A-I      intronic chr21:38748740(+) A-I      intronic chr21:38866403(+) A-I      intronic chr21:38749603(+) A-I      intronic chr21:38748711(+) A-I      intronic chr21:38798958(+) A-I      intronic chr21:38747992(+) A-I      intronic chr21:38750713(+) A-I      intronic chr21:38778788(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	DYRK1A	chr21:38748557(+) A-I intron -    22327324 chr21:38782907(+) A-I exon 5'UTR    22327324 chr21:38782866(+) A-I intron -    21960545 chr21:38782947(+) A-I exon 5'UTR    21960545 chr21:38840467(+) A-I intron -    21960545 chr21:38748557(+) A-G intron -    22484847 chr21:38748562(+) A-G intron -    22484847 chr21:38782907(+) A-G exon 5'UTR    22484847 chr21:38783535(+) A-G intron -    22484847 chr21:38799547(+) A-G intron -    22484847 chr21:38854088(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	DYRK1A	chr21:38739263-38739264(+) m6A exon//intron       24209618//22575960 chr21:38739364-38739365(+) m6A exon//intron       24209618//22575960 chr21:38739464-38739465(+) m6A exon//intron       24209618 chr21:38739594-38739595(+) m1A exon//intron       26863196 chr21:38739696-38739697(+) m6A exon//intron       25456834//24981863 chr21:38739753-38739754(+) m6A exon//intron       25456834//24981863//27371828//22575960 chr21:38739771-38739772(+) m6A exon//intron       25456834//24981863//27371828//22575960 chr21:38739888-38739889(+) m6A 5'UTR//exon//intron       - chr21:38850559-38850560(+) m6A CDS//exon       24981863 chr21:38850581-38850582(+) m6A CDS//exon       24981863 chr21:38852965-38852966(+) m6A CDS//exon       24981863 chr21:38853124-38853125(+) m6A CDS//exon       22575960 chr21:38858826-38858827(+) m6A CDS       22575960 chr21:38884282-38884283(+) m6A 3'UTR//CDS       24284625//24981863//27773535//22608085 chr21:38884300-38884301(+) m6A 3'UTR//CDS       24284625//24981863//27773535//22608085 chr21:38884401-38884402(+) m6A 3'UTR//CDS       24284625//25456834//24981863//26404942//27773535//22575960//22608085 chr21:38884423-38884424(+) m6A 3'UTR//CDS       24284625//25456834//24981863//26404942//27773535//22575960//22608085 chr21:38884613-38884614(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr21:38884620-38884621(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr21:38884675-38884676(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr21:38884689-38884690(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr21:38884746-38884747(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr21:38884844-38884845(+) m6A 3'UTR       24284625//25456834//24981863//27773535//22575960//22608085 chr21:38884897-38884898(+) m6A 3'UTR       24284625//24981863//22575960//22608085 chr21:38884942-38884943(+) m6A 3'UTR       24284625//24981863//22608085 chr21:38884998-38884999(+) m6A 3'UTR       24284625//24981863//22608085 chr21:38885029-38885030(+) m6A 3'UTR       - chr21:38885330-38885331(+) m6A 3'UTR       24284625//25456834//24981863//22575960//22608085 chr21:38885371-38885372(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085 chr21:38885388-38885389(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085 chr21:38885470-38885471(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr21:38885484-38885485(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr21:38885680-38885681(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr21:38885726-38885727(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr21:38885740-38885741(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr21:38885759-38885760(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr21:38885802-38885803(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr21:38886022-38886023(+) m6A 3'UTR       - chr21:38886203-38886204(+) m6A 3'UTR       24284625//24981863//22608085 chr21:38886250-38886251(+) m6A 3'UTR       24284625//24981863//26404942//27773535//22608085 chr21:38886255-38886256(+) m6A 3'UTR       24284625//24981863//26404942//27773535//22608085 chr21:38886261-38886262(+) m6A 3'UTR       24284625//24981863//26404942//27773535//22608085 chr21:38886310-38886311(+) m6A 3'UTR       24284625//24981863//26404942//27773535//22608085 chr21:38886389-38886390(+) m6A 3'UTR       24284625//24981863//22608085 chr21:38886412-38886413(+) m6A 3'UTR       24284625//24981863//22608085 chr21:38886454-38886455(+) m6A 3'UTR       24284625//24981863//22608085 chr21:38886467-38886468(+) m6A 3'UTR       24284625//24981863//22608085 chr21:38886515-38886516(+) m6A 3'UTR       24284625//24981863//22608085 chr21:38886538-38886539(+) m6A 3'UTR       24284625//24981863//22608085 chr21:38887305-38887306(+) m6A 3'UTR       27773535 chr21:38887322-38887323(+) m6A 3'UTR       27773535 chr21:38887328-38887329(+) m6A 3'UTR       27773535 chr21:38887380-38887381(+) m6A 3'UTR       27773535 chr21:38887417-38887418(+) m6A 3'UTR       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-148b-5p	Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
	DYRK1A	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol K562 cells     - Exosome Blood     - Insoluble cytoplasm K562 cells     - Membrane HCC cell line (HepG2)|K562 cells     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-148b-5p
Interactor2: DYRK1A

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	CDS
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.