Basic Information:

  VIRBase ID:  

HHID00066327

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-374a-3p:  MIMAT0004688          ABHD3:  NM_138340     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-374a-3p	ABHD3
miRBase Accession/Entrez ID	MIMAT0004688	171586
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	LABH3

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-374a-3p	rs766292977 chrX:74287300    C/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	ABHD3	chr18:19249107(-) A-I      intronic chr18:19249093(-) A-I      intronic chr18:19247146(-) A-I      intronic chr18:19245601(-) A-I      intronic chr18:19245572(-) A-I      intronic chr18:19245357(-) A-I      intronic chr18:19245152(-) A-I      intronic chr18:19245143(-) A-I      intronic chr18:19234069(-) A-I      intronic chr18:19234085(-) A-I      intronic chr18:19248075(-) A-I      intronic chr18:19245074(-) A-I      intronic chr18:19233288(-) A-I      intronic chr18:19233278(-) A-I      intronic chr18:19233304(-) A-I      intronic chr18:19233305(-) A-I      intronic chr18:19250913(-) A-I      intronic chr18:19250888(-) A-I      intronic chr18:19250810(-) A-I      intronic chr18:19250866(-) A-I      intronic chr18:19250874(-) A-I      intronic chr18:19235787(-) A-I      intronic chr18:19235777(-) A-I      intronic chr18:19235416(-) A-I      intronic chr18:19239832(-) A-I      intronic chr18:19250826(-) A-I      intronic chr18:19245534(-) A-I      intronic chr18:19245380(-) A-I      intronic chr18:19245339(-) A-I      intronic chr18:19232495(-) A-I      intronic chr18:19245262(-) A-I      intronic chr18:19245233(-) A-I      intronic chr18:19245100(-) A-I      intronic chr18:19245088(-) A-I      intronic chr18:19245082(-) A-I      intronic chr18:19245081(-) A-I      intronic chr18:19245034(-) A-I      intronic chr18:19244936(-) A-I      intronic chr18:19234103(-) A-I      intronic chr18:19235359(-) A-I      intronic chr18:19233311(-) A-I      intronic chr18:19232781(-) A-I      intronic chr18:19233313(-) A-I      intronic chr18:19233080(-) A-I      intronic chr18:19233081(-) A-I      intronic chr18:19233303(-) A-I      intronic chr18:19235396(-) A-I      intronic chr18:19235526(-) A-I      intronic chr18:19235629(-) A-I      intronic chr18:19235644(-) A-I      intronic chr18:19235692(-) A-I      intronic chr18:19235701(-) A-I      intronic chr18:19235715(-) A-I      intronic chr18:19235719(-) A-I      intronic chr18:19235758(-) A-I      intronic chr18:19232624(-) A-I      intronic chr18:19250853(-) A-I      intronic chr18:19232627(-) A-I      intronic chr18:19233586(-) A-I      intronic chr18:19233775(-) A-I      intronic chr18:19235769(-) A-I      intronic chr18:19233795(-) A-I      intronic chr18:19233918(-) A-I      intronic chr18:19244933(-) A-I      intronic chr18:19232636(-) A-I      intronic chr18:19242108(-) A-I      intronic chr18:19232653(-) A-I      intronic chr18:19242106(-) A-I      intronic chr18:19232654(-) A-I      intronic chr18:19242103(-) A-I      intronic chr18:19242067(-) A-I      intronic chr18:19242062(-) A-I      intronic chr18:19242054(-) A-I      intronic chr18:19242053(-) A-I      intronic chr18:19242041(-) A-I      intronic chr18:19242002(-) A-I      intronic chr18:19241771(-) A-I      intronic chr18:19241766(-) A-I      intronic chr18:19232494(-) A-I      intronic chr18:19233922(-) A-I      intronic chr18:19233931(-) A-I      intronic chr18:19232674(-) A-I      intronic chr18:19232570(-) A-I      intronic chr18:19233935(-) A-I      intronic chr18:19232628(-) A-I      intronic chr18:19234032(-) A-I      intronic chr18:19241758(-) A-I      intronic chr18:19241570(-) A-I      intronic chr18:19241342(-) A-I      intronic chr18:19239830(-) A-I      intronic chr18:19238111(-) A-I      intronic chr18:19238101(-) A-I      intronic chr18:19238096(-) A-I      intronic chr18:19238049(-) A-I      intronic chr18:19238046(-) A-I      intronic chr18:19236035(-) A-I      intronic chr18:19236034(-) A-I      intronic chr18:19236030(-) A-I      intronic chr18:19236017(-) A-I      intronic chr18:19236008(-) A-I      intronic chr18:19235995(-) A-I      intronic chr18:19235952(-) A-I      intronic chr18:19235926(-) A-I      intronic chr18:19245333(-) A-I      intronic chr18:19235915(-) A-I      intronic chr18:19232700(-) A-I      intronic chr18:19234102(-) A-I      intronic chr18:19248053(-) A-I      intronic chr18:19248014(-) A-I      intronic chr18:19248005(-) A-I      intronic chr18:19247996(-) A-I      intronic chr18:19234014(-) A-I      intronic chr18:19247970(-) A-I      intronic chr18:19247957(-) A-I      intronic chr18:19247933(-) A-I      intronic chr18:19247927(-) A-I      intronic chr18:19247483(-) A-I      intronic chr18:19247469(-) A-I      intronic chr18:19247439(-) A-I      intronic chr18:19247429(-) A-I      intronic chr18:19247421(-) A-I      intronic chr18:19247408(-) A-I      intronic chr18:19247406(-) A-I      intronic chr18:19247380(-) A-I      intronic chr18:19247378(-) A-I      intronic chr18:19247370(-) A-I      intronic chr18:19247366(-) A-I      intronic chr18:19247338(-) A-I      intronic chr18:19247244(-) A-I      intronic chr18:19247197(-) A-I      intronic chr18:19247132(-) A-I      intronic chr18:19247131(-) A-I      intronic chr18:19247127(-) A-I      intronic chr18:19247120(-) A-I      intronic chr18:19246546(-) A-I      intronic chr18:19246356(-) A-I      intronic chr18:19246283(-) A-I      intronic chr18:19246279(-) A-I      intronic chr18:19246266(-) A-I      intronic chr18:19246240(-) A-I      intronic chr18:19246238(-) A-I      intronic chr18:19246223(-) A-I      intronic chr18:19246045(-) A-I      intronic chr18:19246023(-) A-I      intronic chr18:19245735(-) A-I      intronic chr18:19245726(-) A-I      intronic chr18:19245721(-) A-I      intronic chr18:19245716(-) A-I      intronic chr18:19245704(-) A-I      intronic chr18:19245673(-) A-I      intronic chr18:19245649(-) A-I      intronic chr18:19245642(-) A-I      intronic chr18:19245626(-) A-I      intronic chr18:19245552(-) A-I      intronic chr18:19284120(-) A-I      intronic chr18:19284075(-) A-I      intronic chr18:19284074(-) A-I      intronic chr18:19276776(-) A-I      intronic chr18:19275086(-) A-I      intronic chr18:19275041(-) A-I      intronic chr18:19270880(-) A-I      intronic chr18:19270844(-) A-I      intronic chr18:19270751(-) A-I      intronic chr18:19270739(-) A-I      intronic chr18:19270712(-) A-I      intronic chr18:19270699(-) A-I      intronic chr18:19270380(-) A-I      intronic chr18:19270360(-) A-I      intronic chr18:19270358(-) A-I      intronic chr18:19266055(-) A-I      intronic chr18:19265917(-) A-I      intronic chr18:19265835(-) A-I      intronic chr18:19262016(-) A-I      intronic chr18:19261998(-) A-I      intronic chr18:19260256(-) A-I      intronic chr18:19260250(-) A-I      intronic chr18:19260249(-) A-I      intronic chr18:19260209(-) A-I      intronic chr18:19260086(-) A-I      intronic chr18:19260067(-) A-I      intronic chr18:19260027(-) A-I      intronic chr18:19258189(-) A-I      intronic chr18:19258162(-) A-I      intronic chr18:19258135(-) A-I      intronic chr18:19255809(-) A-I      intronic chr18:19250863(-) A-I      intronic chr18:19250851(-) A-I      intronic chr18:19250835(-) A-I      intronic chr18:19250758(-) A-I      intronic chr18:19250732(-) A-I      intronic chr18:19250731(-) A-I      intronic chr18:19249147(-) A-I      intronic chr18:19249143(-) A-I      intronic chr18:19249018(-) A-I      intronic chr18:19245178(-) A-I      intronic chr18:19249155(-) A-I      intronic chr18:19236077(-) A-I      intronic chr18:19267150(-) A-I      intronic chr18:19253307(-) A-I      intronic chr18:19246533(-) A-I      intronic chr18:19258078(-) A-I      intronic chr18:19242182(-) A-I      intronic chr18:19245244(-) A-I      intronic chr18:19248099(-) A-I      intronic chr18:19236078(-) A-I      intronic chr18:19239829(-) A-I      intronic chr18:19241739(-) A-I      intronic chr18:19232203(-) A-I      intronic chr18:19246293(-) A-I      intronic chr18:19265931(-) A-I      intronic chr18:19235679(-) A-I      intronic chr18:19267037(-) A-I      intronic chr18:19250912(-) A-I      intronic chr18:19244795(-) A-I      intronic chr18:19254488(-) A-I      intronic chr18:19281227(-) A-I      intronic chr18:19247474(-) A-I      intronic chr18:19262015(-) A-I      intronic chr18:19232851(-) A-I      intronic chr18:19241364(-) A-I      intronic chr18:19233863(-) A-I      intronic chr18:19260153(-) A-I      intronic chr18:19244808(-) A-I      intronic chr18:19238157(-) A-I      intronic chr18:19241908(-) A-I      intronic chr18:19246337(-) A-I      intronic chr18:19258089(-) A-I      intronic chr18:19244708(-) A-I      intronic chr18:19236190(-) A-I      intronic chr18:19235714(-) A-I      intronic chr18:19241997(-) A-I      intronic chr18:19242204(-) A-I      intronic chr18:19232271(-) A-I      intronic chr18:19233651(-) A-I      intronic chr18:19241429(-) A-I      intronic chr18:19281232(-) A-I      intronic chr18:19244973(-) A-I      intronic chr18:19247917(-) A-I      intronic chr18:19247273(-) A-I      intronic chr18:19241505(-) A-I      intronic chr18:19250880(-) A-I      intronic chr18:19233175(-) A-I      intronic chr18:19248967(-) A-I      intronic chr18:19232236(-) A-I      intronic chr18:19233951(-) A-I      intronic chr18:19253861(-) A-I      intronic chr18:19242245(-) A-I      intronic chr18:19255368(-) A-I      intronic chr18:19262092(-) A-I      intronic chr18:19250782(-) A-I      intronic chr18:19244934(-) A-I      intronic chr18:19248115(-) A-I      intronic chr18:19236054(-) A-I      intronic chr18:19233391(-) A-I      intronic chr18:19245651(-) A-I      intronic chr18:19245375(-) A-I      intronic chr18:19245264(-) A-I      intronic chr18:19245084(-) A-I      intronic chr18:19247940(-) A-I      intronic chr18:19260159(-) A-I      intronic chr18:19250867(-) A-I      intronic chr18:19253838(-) A-I      intronic chr18:19258111(-) A-I      intronic chr18:19239873(-) A-I      intronic chr18:19245315(-) A-I      intronic chr18:19239882(-) A-I      intronic chr18:19248040(-) A-I      intronic chr18:19254412(-) A-I      intronic chr18:19244815(-) A-I      intronic chr18:19248966(-) A-I      intronic chr18:19233274(-) A-I      intronic chr18:19232772(-) A-I      intronic chr18:19236031(-) A-I      intronic chr18:19245661(-) A-I      intronic chr18:19247420(-) A-I      intronic chr18:19241900(-) A-I      intronic chr18:19258195(-) A-I      intronic chr18:19265925(-) A-I      intronic chr18:19246111(-) A-I      intronic chr18:19245101(-) A-I      intronic chr18:19244654(-) A-I      intronic chr18:19245076(-) A-I      intronic chr18:19235584(-) A-I      intronic chr18:19232697(-) A-I      intronic chr18:19244875(-) A-I      intronic chr18:19262011(-) A-I      intronic chr18:19248927(-) A-I      intronic chr18:19242197(-) A-I      intronic chr18:19237937(-) A-I      intronic chr18:19245376(-) A-I      intronic chr18:19245397(-) A-I      intronic chr18:19241928(-) A-I      intronic chr18:19241529(-) A-I      intronic chr18:19237986(-) A-I      intronic chr18:19248954(-) A-I      intronic chr18:19235718(-) A-I      intronic chr18:19233616(-) A-I      intronic chr18:19241336(-) A-I      intronic chr18:19241444(-) A-I      intronic chr18:19278675(-) A-I      intronic chr18:19245173(-) A-I      intronic chr18:19233382(-) A-I      intronic chr18:19250806(-) A-I      intronic chr18:19247173(-) A-I      intronic chr18:19248050(-) A-I      intronic chr18:19245377(-) A-I      intronic chr18:19245607(-) A-I      intronic chr18:19256383(-) A-I      intronic chr18:19245585(-) A-I      intronic chr18:19246343(-) A-I      intronic chr18:19245368(-) A-I      intronic chr18:19246115(-) A-I      intronic chr18:19241426(-) A-I      intronic chr18:19261976(-) A-I      intronic chr18:19245400(-) A-I      intronic chr18:19246563(-) A-I      intronic chr18:19235386(-) A-I      intronic chr18:19277210(-) A-I      intronic chr18:19250892(-) A-I      intronic chr18:19257223(-) A-I      intronic chr18:19239072(-) A-I      intronic chr18:19257930(-) A-I      intronic chr18:19261853(-) A-I      intronic chr18:19233971(-) A-I      intronic chr18:19242243(-) A-I      intronic chr18:19246194(-) A-I      intronic chr18:19261881(-) A-I      intronic chr18:19248949(-) A-I      intronic chr18:19235897(-) A-I      intronic chr18:19235376(-) A-I      intronic chr18:19247398(-) A-I      intronic chr18:19238082(-) A-I      intronic chr18:19241671(-) A-I      intronic chr18:19242341(-) A-I      intronic chr18:19245043(-) A-I      intronic chr18:19260103(-) A-I      intronic chr18:19244968(-) A-I      intronic chr18:19261893(-) A-I      intronic chr18:19253276(-) A-I      intronic chr18:19232481(-) A-I      intronic chr18:19233955(-) A-I      intronic chr18:19245044(-) A-I      intronic chr18:19267038(-) A-I      intronic chr18:19235430(-) A-I      intronic chr18:19250939(-) A-I      intronic chr18:19245274(-) A-I      intronic chr18:19240038(-) A-I      intronic chr18:19233328(-) A-I      intronic chr18:19241509(-) A-I      intronic chr18:19280427(-) A-I      intronic chr18:19238938(-) A-I      intronic chr18:19239824(-) A-I      intronic chr18:19246518(-) A-I      intronic chr18:19245616(-) A-I      intronic chr18:19246110(-) A-I      intronic chr18:19255513(-) A-I      intronic chr18:19237924(-) A-I      intronic chr18:19244991(-) A-I      intronic chr18:19250973(-) A-I      intronic chr18:19234031(-) A-I      intronic chr18:19244868(-) A-I      intronic chr18:19260892(-) A-I      intronic chr18:19249112(-) A-I      intronic chr18:19235752(-) A-I      intronic chr18:19242230(-) A-I      intronic chr18:19259582(-) A-I      intronic chr18:19284055(-) A-I      intronic chr18:19233865(-) A-I      intronic chr18:19258124(-) A-I      intronic chr18:19278634(-) A-I      intronic chr18:19246251(-) A-I      intronic chr18:19250969(-) A-I      intronic chr18:19232771(-) A-I      intronic chr18:19237908(-) A-I      intronic chr18:19239758(-) A-I      intronic chr18:19253839(-) A-I      intronic chr18:19244978(-) A-I      intronic chr18:19238950(-) A-I      intronic chr18:19245294(-) A-I      intronic chr18:19250784(-) A-I      intronic chr18:19238139(-) A-I      intronic chr18:19253366(-) A-I      intronic chr18:19235421(-) A-I      intronic chr18:19234086(-) A-I      intronic chr18:19254341(-) A-I      intronic chr18:19245070(-) A-I      intronic chr18:19249117(-) A-I      intronic chr18:19242005(-) A-I      intronic chr18:19241476(-) A-I      intronic chr18:19233383(-) A-I      intronic chr18:19234077(-) A-I      intronic chr18:19245062(-) A-I      intronic chr18:19250931(-) A-I      intronic chr18:19235427(-) A-I      intronic chr18:19250741(-) A-I      intronic chr18:19241884(-) A-I      intronic chr18:19258112(-) A-I      intronic chr18:19248156(-) A-I      intronic chr18:19245451(-) A-I      intronic chr18:19239726(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	ABHD3	chr18:19236300(-) A-I intron -    22327324 chr18:19247343(-) A-I intron -    22327324 chr18:19232705(-) A-G intron -    22484847 chr18:19233382(-) A-G intron -    22484847 chr18:19233383(-) A-G intron -    22484847 chr18:19233903(-) A-G intron -    22484847 chr18:19236078(-) A-G intron -    22484847 chr18:19236238(-) A-G intron -    22484847 chr18:19236274(-) A-G intron -    22484847 chr18:19241336(-) A-G intron -    22484847 chr18:19241364(-) A-G intron -    22484847 chr18:19241884(-) A-G intron -    22484847 chr18:19241900(-) A-G intron -    22484847 chr18:19241908(-) A-G intron -    22484847 chr18:19241928(-) A-G intron -    22484847 chr18:19244736(-) A-G intron -    22484847 chr18:19244815(-) A-G intron -    22484847 chr18:19244862(-) A-G intron -    22484847 chr18:19244968(-) A-G intron -    22484847 chr18:19244973(-) A-G intron -    22484847 chr18:19245185(-) A-G intron -    22484847 chr18:19245372(-) A-G intron -    22484847 chr18:19245375(-) A-G intron -    22484847 chr18:19245376(-) A-G intron -    22484847 chr18:19245377(-) A-G intron -    22484847 chr18:19245378(-) A-G intron -    22484847 chr18:19245396(-) A-G intron -    22484847 chr18:19245397(-) A-G intron -    22484847 chr18:19245585(-) A-G intron -    22484847 chr18:19246334(-) A-G intron -    22484847 chr18:19246337(-) A-G intron -    22484847 chr18:19246343(-) A-G intron -    22484847 chr18:19247271(-) A-G intron -    22484847 chr18:19247334(-) A-G intron -    22484847 chr18:19247343(-) A-G intron -    22484847 chr18:19247474(-) A-G intron -    22484847 chr18:19247917(-) A-G intron -    22484847 chr18:19247936(-) A-G intron -    22484847 chr18:19248156(-) A-G intron -    22484847 chr18:19249155(-) A-G intron -    22484847 chr18:19250713(-) A-G intron -    22484847 chr18:19250719(-) A-G intron -    22484847 chr18:19250741(-) A-G intron -    22484847 chr18:19250939(-) A-G intron -    22484847 chr18:19250969(-) A-G intron -    22484847 chr18:19253514(-) A-G intron -    22484847 chr18:19259885(-) A-G intron -    22484847 chr18:19261853(-) A-G intron -    22484847 chr18:19262015(-) A-G intron -    22484847 chr18:19265846(-) T-C intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ABHD3	chr18:19230904-19230905(-) m6A 3'UTR       27773535 chr18:19230965-19230966(-) m6A 3'UTR       27773535 chr18:19231011-19231012(-) m6A 3'UTR       27773535 chr18:19231030-19231031(-) m6A 3'UTR       27773535 chr18:19231087-19231088(-) m6A 3'UTR       27773535 chr18:19231223-19231224(-) m6A 3'UTR       27773535 chr18:19231255-19231256(-) m6A 3'UTR       27773535 chr18:19231268-19231269(-) m6A 3'UTR       27773535 chr18:19231305-19231306(-) m6A 3'UTR       27773535 chr18:19231394-19231395(-) m6A 3'UTR       27773535 chr18:19231399-19231400(-) m6A 3'UTR       27773535//22608085 chr18:19231415-19231416(-) m6A 3'UTR       27773535//22608085 chr18:19231520-19231521(-) m6A 3'UTR       24284625//24981863//22608085 chr18:19231560-19231561(-) m6A CDS       24284625//24981863//22608085 chr18:19231566-19231567(-) m6A CDS       24284625//24981863//22608085 chr18:19231626-19231627(-) m6A CDS       24981863//22608085 chr18:19243989-19243990(-) m6A 3'UTR//5'UTR//exon//intron       27773535 chr18:19244009-19244010(-) m6A 3'UTR//5'UTR//exon//intron       27773535 chr18:19282362-19282363(-) Y 5'UTR//CDS//exon       26075521 chr18:19284566-19284567(-) m6A CDS//exon       27773536 chr18:19284606-19284607(-) m6A CDS//exon       27773536 chr18:19284649-19284650(-) m6A 5'UTR//exon       24981863//27773536 chr18:19284736-19284737(-) m6A 5'UTR//exon       24981863//27773536

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-374a-3p	Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
	ABHD3	Chromatin K562 cells     - Exosome Blood     - Insoluble cytoplasm K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-374a-3p
Interactor2: ABHD3

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.