Basic Information:

  VIRBase ID:  

HHID00066324

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-374a-3p:  MIMAT0004688          WFDC8:  NM_130896     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-374a-3p	WFDC8
miRBase Accession/Entrez ID	MIMAT0004688	90199
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	C20orf170//dJ461P17.1//HEL-S-292//WAP8

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-374a-3p	rs766292977 chrX:74287300    C/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	WFDC8	chr20:44180010(-) A-I      3'UTR chr20:44180075(-) A-I      3'UTR chr20:44180119(-) A-I      3'UTR chr20:44180185(-) A-I      3'UTR chr20:44180186(-) A-I      3'UTR chr20:44180211(-) A-I      3'UTR chr20:44180146(-) A-I      3'UTR chr20:44180101(-) A-I      3'UTR chr20:44180110(-) A-I      3'UTR chr20:44207634(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	WFDC8	chr20:44180074(-) A-I exon 3'UTR    15342557 chr20:44180101(-) A-I exon 3'UTR    15342557 chr20:44180110(-) A-I exon 3'UTR    15342557 chr20:44180146(-) A-I exon 3'UTR    15342557 chr20:44180168(-) A-I exon 3'UTR    15342557 chr20:44184375(-) A-I exon CDS    15342557

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-374a-3p	Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
	WFDC8	Cytoplasm Nasopharyngeal carcinoma cells     20498841 Exosome Blood     - Nucleus Nasopharyngeal carcinoma cells     20498841

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-374a-3p
Interactor2: WFDC8

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.