Basic Information:

  VIRBase ID:  

HHID00066322

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-374a-3p:  MIMAT0004688          TBC1D14:  NM_001113361     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-374a-3p	TBC1D14
miRBase Accession/Entrez ID	MIMAT0004688	57533
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	-

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-374a-3p	rs766292977 chrX:74287300    C/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	TBC1D14	chr4:7020844(+) A-I      intronic chr4:7019038(+) A-I      intronic chr4:7018852(+) A-I      intronic chr4:7018841(+) A-I      intronic chr4:6997770(+) A-I      intronic chr4:6997749(+) A-I      intronic chr4:6997746(+) A-I      intronic chr4:6997665(+) A-I      intronic chr4:6997633(+) A-I      intronic chr4:6991989(+) A-I      intronic chr4:6982971(+) A-I      intronic chr4:6977709(+) A-I      intronic chr4:6977705(+) A-I      intronic chr4:6977700(+) A-I      intronic chr4:6977172(+) A-I      intronic chr4:6977171(+) A-I      intronic chr4:6977075(+) A-I      intronic chr4:6977065(+) A-I      intronic chr4:6977029(+) A-I      intronic chr4:6977005(+) A-I      intronic chr4:6976960(+) A-I      intronic chr4:6976876(+) A-I      intronic chr4:6976778(+) A-I      intronic chr4:6976768(+) A-I      intronic chr4:6976765(+) A-I      intronic chr4:6976708(+) A-I      intronic chr4:6960401(+) A-I      intronic chr4:6960382(+) A-I      intronic chr4:6960235(+) A-I      intronic chr4:6959515(+) A-I      intronic chr4:6959493(+) A-I      intronic chr4:6954856(+) A-I      intronic chr4:6951172(+) A-I      intronic chr4:6950807(+) A-I      intronic chr4:6950774(+) A-I      intronic chr4:6950527(+) A-I      intronic chr4:6950526(+) A-I      intronic chr4:6950496(+) A-I      intronic chr4:6950491(+) A-I      intronic chr4:6948309(+) A-I      intronic chr4:6948188(+) A-I      intronic chr4:6936731(+) A-I      intronic chr4:7013961(+) A-I      intronic chr4:6936543(+) A-I      intronic chr4:6935173(+) A-I      intronic chr4:6935165(+) A-I      intronic chr4:6933976(+) A-I      intronic chr4:6933853(+) A-I      intronic chr4:7013773(+) A-I      intronic chr4:6932729(+) A-I      intronic chr4:6932728(+) A-I      intronic chr4:6932727(+) A-I      intronic chr4:6932275(+) A-I      intronic chr4:6915641(+) A-I      intronic chr4:7013485(+) A-I      intronic chr4:7013468(+) A-I      intronic chr4:7013401(+) A-I      intronic chr4:7010162(+) A-I      intronic chr4:6999909(+) A-I      intronic chr4:6999940(+) A-I      intronic chr4:7031423(+) A-I      intronic chr4:7031409(+) A-I      intronic chr4:6999980(+) A-I      intronic chr4:7031402(+) A-I      intronic chr4:7031401(+) A-I      intronic chr4:7031398(+) A-I      intronic chr4:7031396(+) A-I      intronic chr4:7031393(+) A-I      intronic chr4:7031392(+) A-I      intronic chr4:7031387(+) A-I      intronic chr4:7031375(+) A-I      intronic chr4:7028728(+) A-I      intronic chr4:7028693(+) A-I      intronic chr4:7028676(+) A-I      intronic chr4:7013388(+) A-I      intronic chr4:7000346(+) A-I      intronic chr4:6932837(+) A-I      intronic chr4:6932833(+) A-I      intronic chr4:6932817(+) A-I      intronic chr4:6932794(+) A-I      intronic chr4:6932785(+) A-I      intronic chr4:6999993(+) A-I      intronic chr4:7000098(+) A-I      intronic chr4:7000316(+) A-I      intronic chr4:7031431(+) A-I      intronic chr4:7030426(+) A-I      intronic chr4:7030334(+) A-I      intronic chr4:7030328(+) A-I      intronic chr4:7030234(+) A-I      intronic chr4:7030218(+) A-I      intronic chr4:7028699(+) A-I      intronic chr4:7028468(+) A-I      intronic chr4:7028462(+) A-I      intronic chr4:7028459(+) A-I      intronic chr4:7028390(+) A-I      intronic chr4:7028352(+) A-I      intronic chr4:7000431(+) A-I      intronic chr4:6983004(+) A-I      intronic chr4:7000500(+) A-I      intronic chr4:7010160(+) A-I      intronic chr4:7010279(+) A-I      intronic chr4:7013323(+) A-I      intronic chr4:6936591(+) A-I      intronic chr4:7023213(+) A-I      intronic chr4:7022554(+) A-I      intronic chr4:7022521(+) A-I      intronic chr4:7020994(+) A-I      intronic chr4:7020929(+) A-I      intronic chr4:6932757(+) A-I      intronic chr4:6977101(+) A-I      intronic chr4:7031405(+) A-I      intronic chr4:7013851(+) A-I      intronic chr4:6948186(+) A-I      intronic chr4:7013410(+) A-I      intronic chr4:7000405(+) A-I      intronic chr4:7023175(+) A-I      intronic chr4:7000463(+) A-I      intronic chr4:7022507(+) A-I      intronic chr4:6948886(+) A-I      intronic chr4:6977127(+) A-I      intronic chr4:6996467(+) A-I      intronic chr4:7030787(+) A-I      intronic chr4:7027781(+) A-I      intronic chr4:6959524(+) A-I      intronic chr4:6933966(+) A-I      intronic chr4:6932445(+) A-I      intronic chr4:7028720(+) A-I      intronic chr4:6981294(+) A-I      intronic chr4:6948083(+) A-I      intronic chr4:6960345(+) A-I      intronic chr4:6959406(+) A-I      intronic chr4:7013882(+) A-I      intronic chr4:6971164(+) A-I      intronic chr4:7020998(+) A-I      intronic chr4:7028497(+) A-I      intronic chr4:7031502(+) A-I      intronic chr4:7031547(+) A-I      intronic chr4:7030644(+) A-I      intronic chr4:7031458(+) A-I      intronic chr4:7028922(+) A-I      intronic chr4:7030722(+) A-I      intronic chr4:7013908(+) A-I      intronic chr4:7000315(+) A-I      intronic chr4:7013353(+) A-I      intronic chr4:6932404(+) A-I      intronic chr4:6948942(+) A-I      intronic chr4:6932479(+) A-I      intronic chr4:6996570(+) A-I      intronic chr4:7018959(+) A-I      intronic chr4:6936650(+) A-I      intronic chr4:6981139(+) A-I      intronic chr4:6948099(+) A-I      intronic chr4:6981171(+) A-I      intronic chr4:6999369(+) A-I      intronic chr4:6948134(+) A-I      intronic chr4:7030829(+) A-I      intronic chr4:6932654(+) A-I      intronic chr4:7018875(+) A-I      intronic chr4:6932471(+) A-I      intronic chr4:6992187(+) A-I      intronic chr4:7031337(+) A-I      intronic chr4:7031445(+) A-I      intronic chr4:7000330(+) A-I      intronic chr4:6935268(+) A-I      intronic chr4:7013841(+) A-I      intronic chr4:7020954(+) A-I      intronic chr4:7028407(+) A-I      intronic chr4:6948279(+) A-I      intronic chr4:7030615(+) A-I      intronic chr4:7000383(+) A-I      intronic chr4:7031472(+) A-I      intronic chr4:6981276(+) A-I      intronic chr4:6962054(+) A-I      intronic chr4:7028599(+) A-I      intronic chr4:7024834(+) A-I      intronic chr4:7031473(+) A-I      intronic chr4:7013361(+) A-I      intronic chr4:7028856(+) A-I      intronic chr4:7022567(+) A-I      intronic chr4:6922781(+) A-I      intronic chr4:6935101(+) A-I      intronic chr4:6932247(+) A-I      intronic chr4:7028782(+) A-I      intronic chr4:7020946(+) A-I      intronic chr4:6991990(+) A-I      intronic chr4:7018907(+) A-I      intronic chr4:7013845(+) A-I      intronic chr4:6954817(+) A-I      intronic chr4:7028516(+) A-I      intronic chr4:6936236(+) A-I      intronic chr4:7023203(+) A-I      intronic chr4:7028558(+) A-I      intronic chr4:7028377(+) A-I      intronic chr4:7027777(+) A-I      intronic chr4:6997583(+) A-I      intronic chr4:7020932(+) A-I      intronic chr4:6936722(+) A-I      intronic chr4:6981287(+) A-I      intronic chr4:6950485(+) A-I      intronic chr4:7018867(+) A-I      intronic chr4:6932900(+) A-I      intronic chr4:6996536(+) A-I      intronic chr4:7000366(+) A-I      intronic chr4:7024754(+) A-I      intronic chr4:6948287(+) A-I      intronic chr4:6999967(+) A-I      intronic chr4:7018871(+) A-I      intronic chr4:6936619(+) A-I      intronic chr4:7024931(+) A-I      intronic chr4:7031376(+) A-I      intronic chr4:6935216(+) A-I      intronic chr4:7013384(+) A-I      intronic chr4:7030595(+) A-I      intronic chr4:7028533(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	TBC1D14	chr4:6946203(+) A-I intron -    15342557 chr4:6946691(+) A-I intron -    15342557 chr4:6947212(+) A-I intron -    15342557 chr4:6947256(+) A-I intron -    15342557 chr4:6947261(+) A-I intron -    15342557 chr4:6947280(+) A-I intron -    15342557 chr4:6947311(+) A-I intron -    15342557 chr4:6947314(+) A-I intron -    15342557 chr4:6947315(+) A-I intron -    15342557 chr4:6947316(+) A-I intron -    15342557 chr4:6947356(+) A-I intron -    15342557 chr4:6947388(+) A-I intron -    15342557 chr4:6947397(+) A-I intron -    15342557 chr4:6947441(+) G-A intron -    21725310 chr4:6932247(+) A-G intron -    22484847 chr4:6932404(+) A-G intron -    22484847 chr4:6932405(+) A-G intron -    22484847 chr4:6932479(+) A-G intron -    22484847 chr4:6932654(+) A-G intron -    22484847 chr4:6932767(+) A-G intron -    22484847 chr4:6948083(+) A-G intron -    22484847 chr4:6948134(+) A-G intron -    22484847 chr4:6948287(+) A-G intron -    22484847 chr4:6950485(+) A-G intron -    22484847 chr4:6953124(+) T-C intron -    22484847 chr4:6954806(+) A-G intron -    22484847 chr4:6954809(+) A-G intron -    22484847 chr4:6954817(+) A-G intron -    22484847 chr4:6954852(+) A-G intron -    22484847 chr4:6960345(+) A-G intron -    22484847 chr4:6966899(+) T-G intron -    22484847 chr4:6976838(+) A-G intron -    22484847 chr4:6976909(+) A-G intron -    22484847 chr4:6999908(+) A-G intron -    22484847 chr4:6999967(+) A-G intron -    22484847 chr4:7000330(+) A-G intron -    22484847 chr4:7000366(+) A-G intron -    22484847 chr4:7000378(+) A-G intron -    22484847 chr4:7000405(+) A-G intron -    22484847 chr4:7000463(+) A-G intron -    22484847 chr4:7013340(+) A-G intron -    22484847 chr4:7013353(+) A-G intron -    22484847 chr4:7013361(+) A-G intron -    22484847 chr4:7013410(+) A-G intron -    22484847 chr4:7013465(+) A-G intron -    22484847 chr4:7013882(+) A-G intron -    22484847 chr4:7013908(+) A-G intron -    22484847 chr4:7018867(+) A-G intron -    22484847 chr4:7018907(+) A-G intron -    22484847 chr4:7018959(+) A-G intron -    22484847 chr4:7020932(+) A-G intron -    22484847 chr4:7020946(+) A-G intron -    22484847 chr4:7020954(+) A-G intron -    22484847 chr4:7020998(+) A-G intron -    22484847 chr4:7022507(+) A-G intron -    22484847 chr4:7022553(+) A-G intron -    22484847 chr4:7022557(+) A-G intron -    22484847 chr4:7023175(+) A-G intron -    22484847 chr4:7023203(+) A-G intron -    22484847 chr4:7028362(+) A-G intron -    22484847 chr4:7028377(+) A-G intron -    22484847 chr4:7028442(+) A-G intron -    22484847 chr4:7028465(+) A-G intron -    22484847 chr4:7028856(+) A-G intron -    22484847 chr4:7028922(+) A-G intron -    22484847 chr4:7031405(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	TBC1D14	chr4:6925110-6925111(+) m6A 5'UTR       - chr4:6925130-6925131(+) m6A CDS       24284625 chr4:6925189-6925190(+) m6A CDS       24284625//22608085 chr4:6925201-6925202(+) m6A CDS       24284625//22608085 chr4:6925268-6925269(+) m6A CDS       24284625//24981863//22608085 chr4:6925285-6925286(+) m6A CDS       24284625//24981863//22608085 chr4:6925309-6925310(+) m6A CDS       24284625//24981863//22608085 chr4:6925339-6925340(+) m6A CDS       24284625//24981863//22608085 chr4:6925478-6925479(+) m6A CDS       24284625//25456834//24981863//22575960//22608085 chr4:6925512-6925513(+) m6A CDS       24284625//25456834//24981863//22575960//22608085 chr4:6925605-6925606(+) m6A CDS       24284625//25456834//24981863//22575960//22608085 chr4:6925642-6925643(+) m6A CDS       24284625//25456834//24981863//26404942//22575960//22608085 chr4:6925651-6925652(+) m6A CDS       24284625//25456834//24981863//26404942//22575960//22608085 chr4:6925746-6925747(+) m6A CDS       24284625//24209618//24981863//26404942//22575960//22608085 chr4:6925768-6925769(+) m6A CDS       24284625//24209618//24981863//26404942//22575960//22608085 chr4:6956025-6956026(+) m6A 5'UTR//intron       24284625//24981863//22608085 chr4:6956061-6956062(+) m6A CDS//intron       24284625//24981863//22608085 chr4:6969032-6969033(+) m6A CDS       24284625//24981863 chr4:6969048-6969049(+) m6A CDS       24284625//24981863 chr4:6969069-6969070(+) m6A CDS       24284625//24981863 chr4:6995920-6995921(+) m6A 5'UTR//CDS       24209618//24981863 chr4:6995933-6995934(+) m6A 5'UTR//CDS       24209618//24981863 chr4:6995987-6995988(+) m6A 5'UTR//CDS//exon       24209618//24981863 chr4:6996019-6996020(+) m6A 5'UTR//CDS//exon       24981863 chr4:6998066-6998067(+) m6A 5'UTR//CDS//exon       24981863 chr4:6998093-6998094(+) m6A 5'UTR//CDS//exon       24981863 chr4:7006641-7006642(+) Gm CDS       - chr4:7026855-7026856(+) m6A CDS       24284625//25456834 chr4:7026873-7026874(+) m6A CDS       24284625//25456834 chr4:7026915-7026916(+) m6A CDS       24284625//25456834//22575960 chr4:7026972-7026973(+) m6A CDS       24284625//25456834//22575960//22608085 chr4:7032075-7032076(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr4:7032186-7032187(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085 chr4:7032211-7032212(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr4:7032232-7032233(+) Y 3'UTR       26075521 chr4:7032257-7032258(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr4:7032262-7032263(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr4:7032274-7032275(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr4:7032290-7032291(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr4:7032338-7032339(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085 chr4:7032503-7032504(+) m6A 3'UTR       24284625//24209618 chr4:7033001-7033002(+) m6A 3'UTR       24284625 chr4:7033074-7033075(+) m6A 3'UTR       24284625 chr4:7033181-7033182(+) m6A 3'UTR       24284625//22608085 chr4:7033207-7033208(+) m6A 3'UTR       24284625//22608085 chr4:7033290-7033291(+) m6A 3'UTR       24284625//22608085 chr4:7033303-7033304(+) m6A 3'UTR       24284625//22608085 chr4:7033332-7033333(+) m6A 3'UTR       24284625//22608085 chr4:7033432-7033433(+) m6A 3'UTR       24284625 chr4:7033649-7033650(+) m6A 3'UTR       24284625//24209618//24981863//22608085 chr4:7033763-7033764(+) m6A 3'UTR       24284625//24209618//24981863//22608085 chr4:7033818-7033819(+) m6A 3'UTR       24284625//24209618//24981863//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-374a-3p	Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
	TBC1D14	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     - Exosome Blood     - Membrane K562 cells     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-374a-3p
Interactor2: TBC1D14

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.