Basic Information:

  VIRBase ID:  

HHID00066320

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-374a-3p:  MIMAT0004688          AAR2:  NM_001271874     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-374a-3p	AAR2
miRBase Accession/Entrez ID	MIMAT0004688	25980
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	C20orf4//CGI-23

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-374a-3p	rs766292977 chrX:74287300    C/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	AAR2	chr20:34829459(+) A-I      intronic chr20:34835614(+) A-I      intronic chr20:34830995(+) A-I      intronic chr20:34830985(+) A-I      intronic chr20:34836375(+) A-I      intronic chr20:34838980(+) A-I      intronic chr20:34830497(+) A-I      intronic chr20:34838996(+) A-I      intronic chr20:34838998(+) A-I      intronic chr20:34830442(+) A-I      intronic chr20:34830506(+) A-I      intronic chr20:34830514(+) A-I      intronic chr20:34825774(+) A-I      intronic chr20:34830500(+) A-I      intronic chr20:34830964(+) A-I      intronic chr20:34836332(+) A-I      intronic chr20:34836311(+) A-I      intronic chr20:34830392(+) A-I      intronic chr20:34826599(+) A-I      intronic chr20:34826424(+) A-I      intronic chr20:34836440(+) A-I      intronic chr20:34830393(+) A-I      intronic chr20:34836357(+) A-I      intronic chr20:34826587(+) A-I      intronic chr20:34835748(+) A-I      intronic chr20:34830417(+) A-I      intronic chr20:34831013(+) A-I      intronic chr20:34835720(+) A-I      intronic chr20:34826520(+) A-I      intronic chr20:34836387(+) A-I      intronic chr20:34826557(+) A-I      intronic chr20:34826401(+) A-I      intronic chr20:34825945(+) A-I      intronic chr20:34831043(+) A-I      intronic chr20:34829453(+) A-I      intronic chr20:34829447(+) A-I      intronic chr20:34825967(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	AAR2	chr20:34824524-34824525(+) m6A 5'UTR//intron       24284625 chr20:34824654-34824655(+) m6A 5'UTR//intron       - chr20:34827863-34827864(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr20:34827877-34827878(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr20:34827980-34827981(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr20:34828085-34828086(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr20:34828145-34828146(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr20:34828304-34828305(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr20:34828399-34828400(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr20:34828481-34828482(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr20:34828501-34828502(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr20:34832622-34832623(+) m6A CDS       24284625//25456834//24981863//22575960//22608085 chr20:34832696-34832697(+) m6A CDS       24284625//22575960 chr20:34832807-34832808(+) m6A CDS       24284625 chr20:34832822-34832823(+) m6A CDS       24284625 chr20:34843596-34843597(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr20:34843609-34843610(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr20:34843617-34843618(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr20:34843751-34843752(+) m6A 3'UTR//intron       24284625//24209618//24981863 chr20:34843949-34843950(+) m6A 3'UTR//intron       24284625//24209618//24981863//22608085 chr20:34843998-34843999(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//22608085 chr20:34844017-34844018(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//22608085 chr20:34844048-34844049(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//22608085 chr20:34844055-34844056(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//22608085 chr20:34844174-34844175(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//22608085 chr20:34844331-34844332(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//22608085 chr20:34844405-34844406(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//22608085 chr20:34844542-34844543(+) m6A 3'UTR//intron       24284625//24209618//24981863//22608085 chr20:34844654-34844655(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//22608085 chr20:34844687-34844688(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//27773535//22608085 chr20:34844731-34844732(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//27773535//22608085 chr20:34844778-34844779(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//27773535//22608085 chr20:34844851-34844852(+) m6A 3'UTR//intron       24209618//24981863//22608085 chr20:34858456-34858457(+) m6A CDS       22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-374a-3p	Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
	AAR2	Chromatin K562 cells     - Exosome Blood     - Nucleolus K562 cells     - Nucleus HeLa-S3 cells|K562 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-374a-3p
Interactor2: AAR2

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.