Basic Information:

  VIRBase ID:  

HHID00066319

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-374a-3p:  MIMAT0004688          ENDOD1:  NM_015036     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-374a-3p	ENDOD1
miRBase Accession/Entrez ID	MIMAT0004688	23052
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	-

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-374a-3p	rs766292977 chrX:74287300    C/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	ENDOD1	chr11:94859919(+) A-I      intronic chr11:94859984(+) A-I      intronic chr11:94859906(+) A-I      intronic chr11:94856089(+) A-I      intronic chr11:94859908(+) A-I      intronic chr11:94855443(+) A-I      intronic chr11:94847423(+) A-I      intronic chr11:94855440(+) A-I      intronic chr11:94840461(+) A-I      intronic chr11:94855426(+) A-I      intronic chr11:94855410(+) A-I      intronic chr11:94860036(+) A-I      intronic chr11:94833934(+) A-I      intronic chr11:94833881(+) A-I      intronic chr11:94840418(+) A-I      intronic chr11:94833779(+) A-I      intronic chr11:94840387(+) A-I      intronic chr11:94847367(+) A-I      intronic chr11:94841048(+) A-I      intronic chr11:94833753(+) A-I      intronic chr11:94833896(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ENDOD1	chr11:94861604-94861605(+) m6A CDS       24284625//24209618//24981863//22575960//22608085 chr11:94861665-94861666(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr11:94861787-94861788(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr11:94861823-94861824(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr11:94861856-94861857(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr11:94861871-94861872(+) m6A CDS       24284625//24209618//25456834//24981863//22608085 chr11:94861964-94861965(+) m6A CDS       24209618//25456834//24981863//22608085 chr11:94862007-94862008(+) m6A CDS       24209618//24981863//22608085 chr11:94862039-94862040(+) m6A CDS       24209618//24981863//22608085 chr11:94862053-94862054(+) m6A CDS       24209618//24981863//22608085 chr11:94862063-94862064(+) m6A CDS       24209618//24981863//22608085 chr11:94862229-94862230(+) m6A CDS       24981863//22608085 chr11:94862306-94862307(+) m6A CDS       24981863//22608085 chr11:94862600-94862601(+) m6A CDS       24209618//25456834//24981863//22575960//22608085 chr11:94862743-94862744(+) m6A 3'UTR       24209618//24981863//22608085 chr11:94862752-94862753(+) m6A 3'UTR       24209618//24981863//22608085 chr11:94864099-94864100(+) m6A 3'UTR       24981863 chr11:94864190-94864191(+) m6A 3'UTR       24981863 chr11:94864230-94864231(+) m6A 3'UTR       24981863 chr11:94865070-94865071(+) m6A 3'UTR       24981863 chr11:94865110-94865111(+) m6A 3'UTR       24981863//22608085 chr11:94865158-94865159(+) m6A 3'UTR       25456834//24981863//22608085 chr11:94865197-94865198(+) m6A 3'UTR       25456834//24981863//22608085 chr11:94865257-94865258(+) m6A 3'UTR       25456834//24981863//22608085 chr11:94865374-94865375(+) m6A 3'UTR       24981863//22608085 chr11:94865447-94865448(+) m6A 3'UTR       24209618//24981863//22608085 chr11:94865468-94865469(+) m6A 3'UTR       24209618//24981863//22608085 chr11:94865478-94865479(+) m6A 3'UTR       24209618//24981863//22608085 chr11:94865517-94865518(+) m6A 3'UTR       24209618//24981863//26404942//22608085 chr11:94865529-94865530(+) m6A 3'UTR       24209618//24981863//26404942//22608085 chr11:94865550-94865551(+) m6A 3'UTR       24209618//24981863//22608085 chr11:94865584-94865585(+) m6A 3'UTR       24209618//24981863//22575960//22608085 chr11:94865598-94865599(+) m6A 3'UTR       24209618//24981863//22575960//22608085 chr11:94865627-94865628(+) m6A 3'UTR       24209618//25456834//24981863//27773535//22575960//22608085 chr11:94865672-94865673(+) m6A 3'UTR       24209618//24981863//22608085 chr11:94865686-94865687(+) m6A 3'UTR       24209618//24981863//22608085 chr11:94865694-94865695(+) m6A 3'UTR       24209618//24981863//22608085 chr11:94865735-94865736(+) m6A 3'UTR       24209618//24981863//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-374a-3p	Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
	ENDOD1	Exosome Blood     - Nucleoplasm K562 cells     - Ribosome HEK-293 cells     22199352 Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-374a-3p
Interactor2: ENDOD1

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.