Basic Information:

  VIRBase ID:  

HHID00066315

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-374a-3p:  MIMAT0004688          SMARCA2:  NM_001289397     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-374a-3p	SMARCA2
miRBase Accession/Entrez ID	MIMAT0004688	6595
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	BAF190//BRM//hBRM//hSNF2a//NCBRS//SNF2//SNF2L2//SNF2LA//Sth1p//SWI2

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-374a-3p	rs766292977 chrX:74287300    C/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	SMARCA2	chr9:2131775(+) A-I      intronic chr9:2130001(+) A-I      intronic chr9:2129966(+) A-I      intronic chr9:2129954(+) A-I      intronic chr9:2129953(+) A-I      intronic chr9:2148730(+) A-I      intronic chr9:2187451(+) A-I      intronic chr9:2148786(+) A-I      intronic chr9:2148748(+) A-I      intronic chr9:2148731(+) A-I      intronic chr9:2145231(+) A-I      intronic chr9:2148683(+) A-I      intronic chr9:2133472(+) A-I      intronic chr9:2133416(+) A-I      intronic chr9:2148666(+) A-I      intronic chr9:2147919(+) A-I      intronic chr9:2147894(+) A-I      intronic chr9:2147805(+) A-I      intronic chr9:2129357(+) A-I      intronic chr9:2129339(+) A-I      intronic chr9:2129338(+) A-I      intronic chr9:2129261(+) A-I      intronic chr9:2069546(+) A-I      intronic chr9:2069471(+) A-I      intronic chr9:2069444(+) A-I      intronic chr9:2069324(+) A-I      intronic chr9:2069127(+) A-I      intronic chr9:2069098(+) A-I      intronic chr9:2069034(+) A-I      intronic chr9:2069016(+) A-I      intronic chr9:2131779(+) A-I      intronic chr9:2147685(+) A-I      intronic chr9:2131855(+) A-I      intronic chr9:2131819(+) A-I      intronic chr9:2147727(+) A-I      intronic chr9:2147726(+) A-I      intronic chr9:2145085(+) A-I      intronic chr9:2147684(+) A-I      intronic chr9:2069046(+) A-I      intronic chr9:2147636(+) A-I      intronic chr9:2155400(+) A-I      intronic chr9:2147885(+) A-I      intronic chr9:2145223(+) A-I      intronic chr9:2187417(+) A-I      intronic chr9:2152332(+) A-I      intronic chr9:2176651(+) A-I      intronic chr9:2187584(+) A-I      intronic chr9:2069058(+) A-I      intronic chr9:2145209(+) A-I      intronic chr9:2133385(+) A-I      intronic chr9:2148671(+) A-I      intronic chr9:2074629(+) A-I      intronic chr9:2186655(+) A-I      intronic chr9:2133411(+) A-I      intronic chr9:2130115(+) A-I      intronic chr9:2187571(+) A-I      intronic chr9:2069369(+) A-I      intronic chr9:2069101(+) A-I      intronic chr9:2130116(+) A-I      intronic chr9:2174799(+) A-I      intronic chr9:2148770(+) A-I      intronic chr9:2131846(+) A-I      intronic chr9:2174693(+) A-I      intronic chr9:2129987(+) A-I      intronic chr9:2069448(+) A-I      intronic chr9:2153347(+) A-I      intronic chr9:2147582(+) A-I      intronic chr9:2129947(+) A-I      intronic chr9:2147590(+) A-I      intronic chr9:2069056(+) A-I      intronic chr9:2176692(+) A-I      intronic chr9:2186538(+) A-I      intronic chr9:2125629(+) A-I      intronic chr9:2074696(+) A-I      intronic chr9:2133557(+) A-I      intronic chr9:2148783(+) A-I      intronic chr9:2186746(+) A-I      intronic chr9:2147891(+) A-I      intronic chr9:2129303(+) A-I      intronic chr9:2148675(+) A-I      intronic chr9:2069368(+) A-I      intronic chr9:2187443(+) A-I      intronic chr9:2153412(+) A-I      intronic chr9:2187510(+) A-I      intronic chr9:2069394(+) A-I      intronic chr9:2186554(+) A-I      intronic chr9:2129169(+) A-I      intronic chr9:2187493(+) A-I      intronic chr9:2149254(+) A-I      intronic chr9:2186560(+) A-I      intronic chr9:2176810(+) A-I      intronic chr9:2069480(+) A-I      intronic chr9:2187462(+) A-I      intronic chr9:2069393(+) A-I      intronic chr9:2129141(+) A-I      intronic chr9:2068936(+) A-I      intronic chr9:2131820(+) A-I      intronic chr9:2135645(+) A-I      intronic chr9:2187416(+) A-I      intronic chr9:2147612(+) A-I      intronic chr9:2174813(+) A-I      intronic chr9:2129297(+) A-I      intronic chr9:2069543(+) A-I      intronic chr9:2187535(+) A-I      intronic chr9:2153355(+) A-I      intronic chr9:2155387(+) A-I      intronic chr9:2187634(+) A-I      intronic chr9:2187567(+) A-I      intronic chr9:2129202(+) A-I      intronic chr9:2069479(+) A-I      intronic chr9:2186735(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	SMARCA2	chr9:2166442(+) T-C intron -    22484847 chr9:2129271(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	SMARCA2	chr9:2032998-2032999(+) Tm 5'UTR//CDS//exon       - chr9:2039892-2039893(+) m6A CDS       24284625 chr9:2047436-2047437(+) m6A CDS       - chr9:2047450-2047451(+) m6A CDS       - chr9:2058356-2058357(+) Am CDS//exon       - chr9:2058425-2058426(+) m6A CDS//exon       24981863 chr9:2060841-2060842(+) m6A CDS//exon       24981863 chr9:2060861-2060862(+) m6A CDS//exon       24981863 chr9:2060890-2060891(+) m6A CDS//exon       24981863 chr9:2060962-2060963(+) m1A CDS//exon       26863196 chr9:2060983-2060984(+) m1A CDS//exon       26863196 chr9:2070458-2070459(+) m6A CDS       24209618//25456834//24981863//22575960 chr9:2073098-2073099(+) m6A exon//intron       - chr9:2073133-2073134(+) m6A exon//intron       - chr9:2073158-2073159(+) m6A exon//intron       - chr9:2073182-2073183(+) m6A exon//intron       - chr9:2073268-2073269(+) m6A CDS//exon       24209618//24981863//22575960 chr9:2073288-2073289(+) m6A CDS//exon       24209618//24981863//22575960 chr9:2076258-2076259(+) m6A CDS//exon       24981863 chr9:2086971-2086972(+) m6A CDS//exon//intron       - chr9:2115897-2115898(+) m6A CDS//exon//intron       - chr9:2119484-2119485(+) m6A CDS//exon       - chr9:2119491-2119492(+) m6A CDS//exon       - chr9:2123725-2123726(+) m6A CDS//exon       24209618 chr9:2123731-2123732(+) m6A CDS//exon       24209618 chr9:2123755-2123756(+) m6A CDS//exon       24209618 chr9:2123848-2123849(+) m1A CDS//exon       26863196 chr9:2123899-2123900(+) m6A CDS//exon       24209618//24981863 chr9:2158546-2158547(+) m6A 5'UTR//intron       24981863 chr9:2159950-2159951(+) m6A 5'UTR//intron       24981863 chr9:2161828-2161829(+) m6A 3'UTR//CDS//exon       24981863//22608085 chr9:2161849-2161850(+) m6A 3'UTR//CDS       24981863//22608085 chr9:2161890-2161891(+) m6A 3'UTR//CDS       24981863 chr9:2186105-2186106(+) m6A 3'UTR//CDS//exon       24981863//27773535 chr9:2186210-2186211(+) m1A 3'UTR//CDS//exon       26863196 chr9:2191319-2191320(+) m6A 3'UTR//CDS//exon       24209618//24981863//27773535//22608085 chr9:2191362-2191363(+) m6A 3'UTR//CDS//exon       24209618//24981863//27773535//22608085 chr9:2192705-2192706(+) m6A 3'UTR//CDS//exon       24981863//22608085 chr9:2192748-2192749(+) m6A 3'UTR//exon       - chr9:2192766-2192767(+) m6A 3'UTR//exon       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-374a-3p	Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
	SMARCA2	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)     - Cytosolic polysome Human T lymphocytes (Jurkat E6-1)     12923260 Exosome Blood     - Membrane HCC cell line (HepG2)     - Nucleoplasm K562 cells     - Nucleus Colon cancer cells     24393600 Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-374a-3p
Interactor2: SMARCA2

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	CDS
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.