Basic Information:

  VIRBase ID:  

HHID00066312

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-374a-3p:  MIMAT0004688          PDE4B:  NM_001037340     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-374a-3p	PDE4B
miRBase Accession/Entrez ID	MIMAT0004688	5142
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	DPDE4//PDEIVB

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-374a-3p	rs766292977 chrX:74287300    C/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	PDE4B	chr1:66630108(+) A-I      intronic chr1:66630104(+) A-I      intronic chr1:66630040(+) A-I      intronic chr1:66630041(+) A-I      intronic chr1:66630042(+) A-I      intronic chr1:66630047(+) A-I      intronic chr1:66630088(+) A-I      intronic chr1:66630098(+) A-I      intronic chr1:66630099(+) A-I      intronic chr1:66630651(+) A-I      intronic chr1:66630229(+) A-I      intronic chr1:66630198(+) A-I      intronic chr1:66630184(+) A-I      intronic chr1:66602326(+) A-I      intronic chr1:66602313(+) A-I      intronic chr1:66750234(+) A-I      intronic chr1:66676145(+) A-I      intronic chr1:66734308(+) A-I      intronic chr1:66759746(+) A-I      intronic chr1:66640332(+) A-I      intronic chr1:66676070(+) A-I      intronic chr1:66613833(+) A-I      intronic chr1:66502765(+) A-I      intronic chr1:66454928(+) A-I      intronic chr1:66639569(+) A-I      intronic chr1:66630032(+) A-I      intronic chr1:66613767(+) A-I      intronic chr1:66602338(+) A-I      intronic chr1:66630018(+) A-I      intronic chr1:66274759(+) A-I      intronic chr1:66630241(+) A-I      intronic chr1:66612141(+) A-I      intronic chr1:66630205(+) A-I      intronic chr1:66745249(+) A-I      intronic chr1:66639675(+) A-I      intronic chr1:66401376(+) A-I      intronic chr1:66613885(+) A-I      intronic chr1:66602331(+) A-I      intronic chr1:66804199(+) A-I      intronic chr1:66611931(+) A-I      intronic chr1:66288823(+) A-I      intronic chr1:66639570(+) A-I      intronic chr1:66630031(+) A-I      intronic chr1:66630201(+) A-I      intronic chr1:66496468(+) A-I      intronic chr1:66630168(+) A-I      intronic chr1:66734339(+) A-I      intronic chr1:66632170(+) A-I      intronic chr1:66502695(+) A-I      intronic chr1:66496495(+) A-I      intronic chr1:66485143(+) A-I      intronic chr1:66602306(+) A-I      intronic chr1:66632951(+) A-I      intronic chr1:66630511(+) A-I      intronic chr1:66485118(+) A-I      intronic chr1:66743140(+) A-I      intronic chr1:66501464(+) A-I      intronic chr1:66519422(+) A-I      intronic chr1:66613725(+) A-I      intronic chr1:66694224(+) A-I      intronic chr1:66582270(+) A-I      intronic chr1:66630022(+) A-I      intronic chr1:66274750(+) A-I      intronic chr1:66630140(+) A-I      intronic chr1:66630479(+) A-I      intronic chr1:66753644(+) A-I      intronic chr1:66761212(+) A-I      intronic chr1:66835755(+) A-I      intronic chr1:66456847(+) A-I      intronic chr1:66485132(+) A-I      intronic chr1:66483938(+) A-I      intronic chr1:66734240(+) A-I      intronic chr1:66720791(+) A-I      intronic chr1:66467551(+) A-I      intronic chr1:66761170(+) A-I      intronic chr1:66639642(+) A-I      intronic chr1:66542076(+) A-I      intronic chr1:66270910(+) A-I      intronic chr1:66377951(+) A-I      intronic chr1:66406155(+) A-I      intronic chr1:66540622(+) A-I      intronic chr1:66502705(+) A-I      intronic chr1:66745201(+) A-I      intronic chr1:66483881(+) A-I      intronic chr1:66454929(+) A-I      intronic chr1:66485138(+) A-I      intronic chr1:66485219(+) A-I      intronic chr1:66639653(+) A-I      intronic chr1:66496547(+) A-I      intronic chr1:66630062(+) A-I      intronic chr1:66632928(+) A-I      intronic chr1:66612073(+) A-I      intronic chr1:66483934(+) A-I      intronic chr1:66406036(+) A-I      intronic chr1:66630203(+) A-I      intronic chr1:66542063(+) A-I      intronic chr1:66501453(+) A-I      intronic chr1:66743351(+) A-I      intronic chr1:66613832(+) A-I      intronic chr1:66694227(+) A-I      intronic chr1:66406221(+) A-I      intronic chr1:66613699(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	PDE4B	chr1:66829350(+) C-T intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	PDE4B	chr1:66458314-66458315(+) m6A 5'UTR//exon//intron       24981863 chr1:66458483-66458484(+) m6A 5'UTR//exon//intron       24981863 chr1:66458501-66458502(+) m6A 5'UTR//exon//intron       24981863 chr1:66458587-66458588(+) m6A 5'UTR//exon//intron       24981863//26404942 chr1:66458615-66458616(+) m6A CDS//exon//intron       24981863//26404942 chr1:66458630-66458631(+) m6A CDS//exon//intron       24981863//26404942 chr1:66458649-66458650(+) m6A CDS//exon//intron       24981863//26404942 chr1:66458675-66458676(+) m6A CDS//exon//intron       24981863//26404942 chr1:66458701-66458702(+) m6A CDS//exon//intron       24981863//26404942 chr1:66458746-66458747(+) m6A CDS//exon//intron       24981863 chr1:66797807-66797808(+) m6A 5'UTR//intron       - chr1:66797843-66797844(+) m6A 5'UTR//intron       24981863 chr1:66797874-66797875(+) m6A 5'UTR//intron       24981863 chr1:66797903-66797904(+) m6A 5'UTR//intron       24981863 chr1:66797984-66797985(+) m6A 5'UTR//intron       24981863 chr1:66798139-66798140(+) m6A CDS//intron       24981863 chr1:66798235-66798236(+) m6A CDS       24981863 chr1:66833820-66833821(+) m6A exon//intron       - chr1:66834497-66834498(+) m6A CDS       - chr1:66834541-66834542(+) m6A CDS       - chr1:66834578-66834579(+) m6A CDS       - chr1:66834624-66834625(+) m6A CDS       24981863 chr1:66838034-66838035(+) m6A CDS       25456834//24981863//26404942 chr1:66838068-66838069(+) m6A CDS       25456834//24981863//26404942//22608085 chr1:66838098-66838099(+) m6A CDS       25456834//24981863//26404942//22575960//22608085 chr1:66838152-66838153(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr1:66838158-66838159(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr1:66838192-66838193(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr1:66838222-66838223(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr1:66838243-66838244(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr1:66838293-66838294(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr1:66838313-66838314(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr1:66838323-66838324(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr1:66838338-66838339(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr1:66838384-66838385(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr1:66838446-66838447(+) m6A 3'UTR       24209618//25456834//24981863//26404942//22575960//22608085 chr1:66838457-66838458(+) m6A 3'UTR       24209618//25456834//24981863//26404942//22575960//22608085 chr1:66838508-66838509(+) m6A 3'UTR       24209618//25456834//24981863//26404942//22608085 chr1:66838613-66838614(+) m6A 3'UTR       25456834//24981863//26404942 chr1:66838635-66838636(+) m6A 3'UTR       25456834//24981863//26404942 chr1:66838642-66838643(+) m6A 3'UTR       25456834//24981863//26404942 chr1:66838674-66838675(+) m6A 3'UTR       25456834//24981863//26404942 chr1:66838696-66838697(+) m6A 3'UTR       25456834//24981863//26404942 chr1:66838774-66838775(+) m6A 3'UTR       24981863//26404942 chr1:66838948-66838949(+) m6A 3'UTR       24981863 chr1:66839028-66839029(+) m6A 3'UTR       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-374a-3p	Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
	PDE4B	Exosome Blood     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-374a-3p
Interactor2: PDE4B

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.