Detail Information

Basic Information:


  VIRBase ID:  

HHID00066309

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-374a-3p:           LIPA:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-374a-3p LIPA
miRBase
Accession/Entrez ID		 MIMAT0004688 3988
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - CESD//LAL

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-374a-3p
rs766292977 chrX:74287300    C/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR LIPA
chr10:90990287(-) A-I      intronic
chr10:90989388(-) A-I      intronic
chr10:90989351(-) A-I      intronic
chr10:90989386(-) A-I      intronic
chr10:90989398(-) A-I      intronic
chr10:91008480(-) A-I      intronic
chr10:90990257(-) A-I      intronic
chr10:91091888(-) A-I      intronic
chr10:90990195(-) A-I      intronic
chr10:90990318(-) A-I      intronic
chr10:90989410(-) A-I      intronic
chr10:90990210(-) A-I      intronic
chr10:90990335(-) A-I      intronic
chr10:90989290(-) A-I      intronic
chr10:91007832(-) A-I      intronic
chr10:90989273(-) A-I      intronic
chr10:90989424(-) A-I      intronic
chr10:90989427(-) A-I      intronic
chr10:90990246(-) A-I      intronic
chr10:91008118(-) A-I      intronic
chr10:90990265(-) A-I      intronic
chr10:91009859(-) A-I      intronic
chr10:90993510(-) A-I      intronic
chr10:90989311(-) A-I      intronic
chr10:90993511(-) A-I      intronic
chr10:90990276(-) A-I      intronic
chr10:91007798(-) A-I      intronic
chr10:90990203(-) A-I      intronic
chr10:90976991(-) A-I      intronic
chr10:90977515(-) A-I      intronic
chr10:91006883(-) A-I      intronic
chr10:90976994(-) A-I      intronic
chr10:90977066(-) A-I      intronic
chr10:90977488(-) A-I      intronic
chr10:90977625(-) A-I      intronic
chr10:90990161(-) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase LIPA
chr10:90973365-90973366(-) m6A 3'UTR       -
chr10:90973875-90973876(-) m6A 3'UTR       26404942
chr10:90973903-90973904(-) m6A 3'UTR       26404942
chr10:90973909-90973910(-) m6A 3'UTR       26404942
chr10:90973927-90973928(-) m6A 3'UTR       26404942
chr10:90974415-90974416(-) m6A 3'UTR       -
chr10:90974508-90974509(-) m6A 3'UTR       24981863//26404942//22608085
chr10:90974526-90974527(-) Y 3'UTR       26075521
chr10:90974576-90974577(-) m6A 3'UTR       24284625//24209618//24981863//26404942//22608085
chr10:91007359-91007360(-) m6A CDS//intron       27371828
chr10:91007422-91007423(-) m6A 5'UTR//intron       24981863//27371828
chr10:91007489-91007490(-) m6A 5'UTR//intron       24981863
chr10:91011502-91011503(-) m6A 5'UTR//intron       24981863//27773536
chr10:91011518-91011519(-) m6A 5'UTR//intron       24981863//27773536
chr10:91011582-91011583(-) m6A 5'UTR//intron       24981863//27773536
chr10:91011628-91011629(-) m6A 5'UTR//intron       24981863//27773536
chr10:91095112-91095113(-) m6A exon//intron       24981863
chr10:91095122-91095123(-) m6A exon//intron       24981863
chr10:91095143-91095144(-) m6A exon//intron       24981863
chr10:91095205-91095206(-) m6A exon//intron       24981863
chr10:91174279-91174280(-) m6A 5'UTR       -
chr10:91174285-91174286(-) m6A 5'UTR       -
chr10:91174305-91174306(-) m6A 5'UTR       -

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-374a-3p
Exosome Plasma     23663360
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
LIPA
Exosome Blood     -
Ribosome HEK-293 cells     22199352
Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-374a-3p
Interactor2: LIPA

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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