Basic Information:

  VIRBase ID:  

HHID00066306

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-374a-3p:  MIMAT0004688          HIC1:  NM_001098202     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-374a-3p	HIC1
miRBase Accession/Entrez ID	MIMAT0004688	3090
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	hic-1//ZBTB29//ZNF901

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-374a-3p	rs766292977 chrX:74287300    C/T

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	HIC1	chr17:1958425-1958426(+) m6A 5'UTR       - chr17:1958434-1958435(+) m6A 5'UTR       - chr17:1959622-1959623(+) m6A 5'UTR//CDS//intron       - chr17:1959672-1959673(+) m6A 5'UTR//intron       - chr17:1959991-1959992(+) m6A CDS       - chr17:1960180-1960181(+) m6A CDS       24981863//22608085 chr17:1960222-1960223(+) m6A CDS       24981863//22608085 chr17:1960592-1960593(+) m6A CDS       - chr17:1960654-1960655(+) m6A CDS       - chr17:1960732-1960733(+) m6A CDS       - chr17:1960871-1960872(+) m6A CDS       - chr17:1961398-1961399(+) m6A CDS       - chr17:1961479-1961480(+) m6A CDS       24284625 chr17:1961571-1961572(+) m6A CDS       24284625 chr17:1961923-1961924(+) m6A CDS       24981863//22575960//22608085 chr17:1961955-1961956(+) m6A CDS       24981863//22575960//22608085 chr17:1962102-1962103(+) m6A CDS       24981863 chr17:1962225-1962226(+) m6A 3'UTR       - chr17:1962580-1962581(+) m6A 3'UTR       - chr17:1963896-1963897(+) m1A 3'UTR       26863196

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-374a-3p	Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
	HIC1	Exosome Blood     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-374a-3p
Interactor2: HIC1

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.