Basic Information:

  VIRBase ID:  

HHID00066305

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-374a-3p:  MIMAT0004688          DCK:  NM_000788     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-374a-3p	DCK
miRBase Accession/Entrez ID	MIMAT0004688	1633
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	-

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-374a-3p	rs766292977 chrX:74287300    C/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	DCK	chr4:71871471(+) A-I      intronic chr4:71871482(+) A-I      intronic chr4:71871493(+) A-I      intronic chr4:71894224(+) A-I      intronic chr4:71887559(+) A-I      intronic chr4:71883914(+) A-I      intronic chr4:71883913(+) A-I      intronic chr4:71876747(+) A-I      intronic chr4:71871696(+) A-I      intronic chr4:71861812(+) A-I      intronic chr4:71894164(+) A-I      intronic chr4:71887647(+) A-I      intronic chr4:71887598(+) A-I      intronic chr4:71894476(+) A-I      intronic chr4:71894047(+) A-I      intronic chr4:71871439(+) A-I      intronic chr4:71894369(+) A-I      Syn:Gln->Gln chr4:71887491(+) A-I      intronic chr4:71861819(+) A-I      intronic chr4:71861713(+) A-I      intronic chr4:71871366(+) A-I      intronic chr4:71871402(+) A-I      intronic chr4:71894158(+) A-I      intronic chr4:71861042(+) A-I      intronic chr4:71894099(+) A-I      intronic chr4:71894127(+) A-I      intronic chr4:71864561(+) A-I      intronic chr4:71894811(+) A-I      intronic chr4:71894374(+) A-I      NonSyn:His->Arg

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	DCK	chr4:71871366(+) A-G intron -    22484847 chr4:71871439(+) A-G intron -    22484847 chr4:71885509(+) A-T intron -    22484847 chr4:71887491(+) A-G intron -    22484847 chr4:71894369(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	DCK	chr4:71859283-71859284(+) m6A 5'UTR//intron       24981863 chr4:71859399-71859400(+) m6A 5'UTR//intron       24981863 chr4:71859544-71859545(+) m6A 5'UTR       24284625 chr4:71859606-71859607(+) m6A CDS       24284625

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-374a-3p	Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
	DCK	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)     - Exosome Blood     - Insoluble cytoplasm HCC cell line (HepG2)     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-374a-3p
Interactor2: DCK

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.