Detail Information

Basic Information:


  VIRBase ID:  

HHID00066129

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-34c-3p:           ARL4A:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-34c-3p ARL4A
miRBase
Accession/Entrez ID		 MIMAT0004677 10124
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - ARL4

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-34c-3p
rs1282850577 chr11:111513500    G/T
rs1295199361 chr11:111513499    G/A
rs1395145737 chr11:111513493    C/A
rs745869935 chr11:111513497    A/G
rs757470011 chr11:111513484    A/G
rs772208301 chr11:111513505    G/A
rs779046195 chr11:111513496    C/T
rs886120164 chr11:111513498    C/T
rs894158732 chr11:111513504    G/A
rs1051896302 chr11:111513489    C/T

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase ARL4A
chr7:12726489-12726490(+) m6A 5'UTR       24981863
chr7:12726596-12726597(+) m6A 5'UTR       24981863
chr7:12727198-12727199(+) m6A 5'UTR//intron       24981863
chr7:12727332-12727333(+) m6A 5'UTR//intron       24284625//24981863//27773535
chr7:12727338-12727339(+) m6A 5'UTR//intron       24284625//24981863//27773535
chr7:12727829-12727830(+) m6A 5'UTR       24284625//24209618//25456834//24981863//27773535//22608085
chr7:12727859-12727860(+) m6A 5'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr7:12727898-12727899(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr7:12727903-12727904(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr7:12727964-12727965(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22608085
chr7:12727978-12727979(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22608085
chr7:12728080-12728081(+) m6A CDS       24981863//22608085
chr7:12728180-12728181(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr7:12728215-12728216(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr7:12728220-12728221(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr7:12728283-12728284(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr7:12728297-12728298(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr7:12728343-12728344(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr7:12728412-12728413(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22608085
chr7:12728421-12728422(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22608085
chr7:12728609-12728610(+) m6A 3'UTR       24981863
chr7:12728748-12728749(+) m6A 3'UTR       24981863//27773535//22608085
chr7:12728788-12728789(+) m6A 3'UTR       24981863//27773535//22608085
chr7:12729278-12729279(+) m6A 3'UTR       24981863//22608085
chr7:12729321-12729322(+) m6A 3'UTR       24981863//22608085
chr7:12729596-12729597(+) m6A 3'UTR       27773535

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-34c-3p
Exosome Plasma     23663360
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Seminal plasma     23539611
Microvesicle Fibroblasts|Mesenchymal stem cells     -
ARL4A
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-34c-3p
5-Fluorouracil 3385 Drug interaction    RC00007062
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-34c-3p
Doxorubicin 31703       25698578
Resource Symbol Drug Name PubChem ID
RNAactDrug hsa-miR-34c-3p
l-685,458       5479543
Crizotinib       11626560

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-34c-3p
Interactor2: ARL4A

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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