Detail Information

Basic Information:


  VIRBase ID:  

HHID00066074

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-194-3p:           SIAH1:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-194-3p SIAH1
miRBase
Accession/Entrez ID		 MIMAT0004671 6477
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - SIAH1A

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-194-3p
rs1163841393 chr11:64891375    C/T
rs1385637052 chr11:64891389    G/A
rs772002778 chr11:64891380    G/T
rs936633098 chr11:64891370    G/A
rs1162071131 chr11:64891384    C/A
rs777631483 chr11:64891382    C/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR SIAH1
chr16:48395694(-) A-I      NonSyn:Lys->Glu
chr16:48395693(-) A-I      NonSyn:Lys->Arg
chr16:48395682(-) A-I      NonSyn:Asn->Asp
chr16:48395683(-) A-I      Syn:Glu->Glu
chr16:48395718(-) A-I      NonSyn:Ile->Val
chr16:48395672(-) A-I      NonSyn:Tyr->Cys
chr16:48395658(-) A-I      NonSyn:Asn->Asp
chr16:48395657(-) A-I      NonSyn:Asn->Ser
chr16:48395729(-) A-I      NonSyn:Gln->Arg
chr16:48395704(-) A-I      NonSyn:Ile->Met
chr16:48411399(-) A-I      intronic
chr16:48411378(-) A-I      intronic
chr16:48398025(-) A-I      intronic
chr16:48398017(-) A-I      intronic
chr16:48398030(-) A-I      intronic
chr16:48398038(-) A-I      intronic
chr16:48411767(-) A-I      intronic
chr16:48411786(-) A-I      intronic
chr16:48412012(-) A-I      intronic
chr16:48412129(-) A-I      intronic
chr16:48412019(-) A-I      intronic
chr16:48412182(-) A-I      intronic
chr16:48415193(-) A-I      intronic
chr16:48416070(-) A-I      intronic
chr16:48416085(-) A-I      intronic
chr16:48412259(-) A-I      intronic
chr16:48412052(-) A-I      intronic
chr16:48412058(-) A-I      intronic
chr16:48411406(-) A-I      intronic
chr16:48411437(-) A-I      intronic
chr16:48412257(-) A-I      intronic
chr16:48400946(-) A-I      intronic
chr16:48401062(-) A-I      intronic
chr16:48411479(-) A-I      intronic
chr16:48412181(-) A-I      intronic
chr16:48412251(-) A-I      intronic
chr16:48412152(-) A-I      intronic
chr16:48403531(-) A-I      intronic
chr16:48411588(-) A-I      intronic
chr16:48403541(-) A-I      intronic
chr16:48412116(-) A-I      intronic
chr16:48411579(-) A-I      intronic
chr16:48411732(-) A-I      intronic
chr16:48403577(-) A-I      intronic
chr16:48412220(-) A-I      intronic
chr16:48416216(-) A-I      intronic
chr16:48411428(-) A-I      intronic
chr16:48409462(-) A-I      intronic
chr16:48412046(-) A-I      intronic
chr16:48411580(-) A-I      intronic
chr16:48411525(-) A-I      intronic
chr16:48403641(-) A-I      intronic
chr16:48411533(-) A-I      intronic
chr16:48414354(-) A-I      intronic
chr16:48400980(-) A-I      intronic
chr16:48402433(-) A-I      intronic
chr16:48400905(-) A-I      intronic
chr16:48400963(-) A-I      intronic
chr16:48411438(-) A-I      intronic
chr16:48412225(-) A-I      intronic
chr16:48400981(-) A-I      intronic
chr16:48411524(-) A-I      intronic
chr16:48403465(-) A-I      intronic
chr16:48411601(-) A-I      intronic
chr16:48403571(-) A-I      intronic
chr16:48411482(-) A-I      intronic
chr16:48403553(-) A-I      intronic
chr16:48416214(-) A-I      intronic
chr16:48411467(-) A-I      intronic
chr16:48414184(-) A-I      intronic
chr16:48414301(-) A-I      intronic
chr16:48412218(-) A-I      intronic
chr16:48411562(-) A-I      intronic
chr16:48410557(-) A-I      intronic
chr16:48411398(-) A-I      intronic
chr16:48415011(-) A-I      intronic
chr16:48398043(-) A-I      intronic
chr16:48402434(-) A-I      intronic
chr16:48411403(-) A-I      intronic
chr16:48412124(-) A-I      intronic
chr16:48403446(-) A-I      intronic
chr16:48401038(-) A-I      intronic
chr16:48398632(-) A-I      intronic
chr16:48411468(-) A-I      intronic
chr16:48411367(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED SIAH1
chr16:48411437(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase SIAH1
chr16:48395290-48395291(-) m6A 3'UTR//intron       24981863//27773535//22608085
chr16:48395339-48395340(-) m6A 3'UTR//intron       24284625//24209618//24981863//27773535//22608085
chr16:48395382-48395383(-) m6A 3'UTR//exon//intron       24284625//24209618//24981863//27773535//27371828//22608085
chr16:48395406-48395407(-) m6A 3'UTR//exon       24284625//24209618//24981863//27773535//27371828//22575960//22608085
chr16:48395454-48395455(-) m6A 3'UTR//exon       24284625//24209618//24981863//27773535//27371828//22575960//22608085
chr16:48395477-48395478(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr16:48395699-48395700(-) m6A CDS//exon       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr16:48395754-48395755(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr16:48395833-48395834(-) m6A CDS       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr16:48395992-48395993(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr16:48396326-48396327(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr16:48396407-48396408(-) m6A 5'UTR//intron       24284625//24209618//27371828//22608085
chr16:48396422-48396423(-) m6A 5'UTR//intron       22608085
chr16:48396433-48396434(-) m6A 5'UTR//intron       22608085
chr16:48396562-48396563(-) m6A 5'UTR//intron       22608085
chr16:48396678-48396679(-) m6A 5'UTR//intron       22608085
chr16:48396816-48396817(-) m6A 5'UTR//intron       22608085

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-194-3p
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
SIAH1
Chromatin K562 cells     -
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HCC cell line (HepG2)|HeLa-S3 cells     -

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-194-3p
Interactor2: SIAH1

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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