Basic Information:

  VIRBase ID:  

HHID00066072

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-194-3p:  MIMAT0004671          RB1:  NM_000321     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-194-3p	RB1
miRBase Accession/Entrez ID	MIMAT0004671	5925
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	OSRC//p105-Rb//p110-RB1//pp110//PPP1R130//pRb//RB

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-194-3p	rs1163841393 chr11:64891375    C/T rs1385637052 chr11:64891389    G/A rs772002778 chr11:64891380    G/T rs936633098 chr11:64891370    G/A rs1162071131 chr11:64891384    C/A rs777631483 chr11:64891382    C/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	RB1	chr13:48997124(+) A-I      intronic chr13:48997123(+) A-I      intronic chr13:48997139(+) A-I      intronic chr13:48997181(+) A-I      intronic chr13:48956188(+) A-I      intronic chr13:48978743(+) A-I      intronic chr13:48964140(+) A-I      intronic chr13:48988381(+) A-I      intronic chr13:48950557(+) A-I      intronic chr13:48950476(+) A-I      intronic chr13:48988376(+) A-I      intronic chr13:49034950(+) A-I      intronic chr13:49034887(+) A-I      intronic chr13:49034872(+) A-I      intronic chr13:49034825(+) A-I      intronic chr13:48988271(+) A-I      intronic chr13:48965708(+) A-I      intronic chr13:48978843(+) A-I      intronic chr13:49034389(+) A-I      intronic chr13:49034239(+) A-I      intronic chr13:49034206(+) A-I      intronic chr13:49034169(+) A-I      intronic chr13:49018532(+) A-I      intronic chr13:49018503(+) A-I      intronic chr13:48950580(+) A-I      intronic chr13:49008334(+) A-I      intronic chr13:48950548(+) A-I      intronic chr13:49008328(+) A-I      intronic chr13:48989662(+) A-I      intronic chr13:48989649(+) A-I      intronic chr13:48978066(+) A-I      intronic chr13:48989590(+) A-I      intronic chr13:48949792(+) A-I      intronic chr13:48950556(+) A-I      intronic chr13:48894987(+) A-I      intronic chr13:48989528(+) A-I      intronic chr13:48978039(+) A-I      intronic chr13:48965619(+) A-I      intronic chr13:48978016(+) A-I      intronic chr13:48950423(+) A-I      intronic chr13:48989667(+) A-I      intronic chr13:48950513(+) A-I      intronic chr13:48966524(+) A-I      intronic chr13:48989516(+) A-I      intronic chr13:48964138(+) A-I      intronic chr13:48966523(+) A-I      intronic chr13:48966444(+) A-I      intronic chr13:48978763(+) A-I      intronic chr13:48989509(+) A-I      intronic chr13:48880518(+) A-I      intronic chr13:48966537(+) A-I      intronic chr13:48988389(+) A-I      intronic chr13:48886111(+) A-I      intronic chr13:48966431(+) A-I      intronic chr13:48950424(+) A-I      intronic chr13:48989582(+) A-I      intronic chr13:48888750(+) A-I      intronic chr13:48966340(+) A-I      intronic chr13:48988220(+) A-I      intronic chr13:48965700(+) A-I      intronic chr13:48964139(+) A-I      intronic chr13:48965681(+) A-I      intronic chr13:48949935(+) A-I      intronic chr13:48965677(+) A-I      intronic chr13:48964143(+) A-I      intronic chr13:48989533(+) A-I      intronic chr13:48906578(+) A-I      intronic chr13:48888158(+) A-I      intronic chr13:48989596(+) A-I      intronic chr13:49034919(+) A-I      intronic chr13:49035055(+) A-I      intronic chr13:48888146(+) A-I      intronic chr13:48888092(+) A-I      intronic chr13:49034285(+) A-I      intronic chr13:48989605(+) A-I      intronic chr13:48965977(+) A-I      intronic chr13:48888067(+) A-I      intronic chr13:48950551(+) A-I      intronic chr13:49035053(+) A-I      intronic chr13:48888011(+) A-I      intronic chr13:49034386(+) A-I      intronic chr13:48950475(+) A-I      intronic chr13:48888888(+) A-I      intronic chr13:48989520(+) A-I      intronic chr13:48965613(+) A-I      intronic chr13:48989581(+) A-I      intronic chr13:48963208(+) A-I      intronic chr13:48950494(+) A-I      intronic chr13:49048387(+) A-I      intronic chr13:48965629(+) A-I      intronic chr13:48978764(+) A-I      intronic chr13:48950422(+) A-I      intronic chr13:48888848(+) A-I      intronic chr13:48965952(+) A-I      intronic chr13:48961733(+) A-I      intronic chr13:48978682(+) A-I      intronic chr13:48888790(+) A-I      intronic chr13:48989650(+) A-I      intronic chr13:49035022(+) A-I      intronic chr13:49034932(+) A-I      intronic chr13:48978719(+) A-I      intronic chr13:49034380(+) A-I      intronic chr13:48966412(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	RB1	chr13:48881835(+) C-A intron -    22484847 chr13:48882797(+) A-C intron -    22484847 chr13:48882798(+) C-A intron -    22484847 chr13:48888108(+) A-C intron -    22484847 chr13:48963208(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	RB1	chr13:48878060-48878061(+) m6A CDS//exon       24209618//24981863//27371828 chr13:48878104-48878105(+) m6A CDS//exon       24209618//27371828 chr13:48878142-48878143(+) m6A CDS//exon       24209618//27371828 chr13:48878154-48878155(+) m6A CDS//exon       24209618//27371828 chr13:48878169-48878170(+) m6A CDS//exon       24209618//27371828 chr13:48919310-48919311(+) Y CDS//exon//intron       26075521 chr13:49030412-49030413(+) m6A CDS//exon       24981863 chr13:49030436-49030437(+) m6A CDS//exon       24981863 chr13:49039177-49039178(+) Y CDS       26075521 chr13:49050836-49050837(+) m6A CDS//exon       24981863 chr13:49050925-49050926(+) m6A CDS//exon       24284625//24981863 chr13:49050937-49050938(+) m6A CDS//exon       24284625//24981863 chr13:49051493-49051494(+) m6A CDS//exon       24284625//24981863 chr13:49051526-49051527(+) m6A CDS//exon       24284625//24981863 chr13:49054144-49054145(+) m6A CDS//exon       24284625//24981863 chr13:49054190-49054191(+) m6A CDS//exon       24981863 chr13:49054217-49054218(+) m6A 3'UTR//exon       24981863 chr13:49054227-49054228(+) m6A 3'UTR//exon       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-194-3p	Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
	RB1	Chromatin K562 cells     - Exosome Blood     - Nucleoplasm K562 cells     - Nucleus Colon cancer cells     24393600 Nucleus HCC cell line (HepG2)|HeLa-S3 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-194-3p
Interactor2: RB1

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	CDS
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.