Basic Information:

  VIRBase ID:  

HHID00066040

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-200c-5p:  MIMAT0004657          TMED7:  NM_181836     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-200c-5p	TMED7
miRBase Accession/Entrez ID	MIMAT0004657	51014
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	CGI-109//p24g3//p24gamma3//p27

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-200c-5p	rs1220589670 chr12:6963703    C/T rs1277597787 chr12:6963716    A/C rs372372905 chr12:6963719    G/A rs942672545 chr12:6963713    A/G rs1318673559 chr12:6963704    G/A

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	TMED7	chr5:114950536-114950537(-) m6A 3'UTR       26404942 chr5:114951186-114951187(-) m6A 3'UTR       26404942//27773535 chr5:114951224-114951225(-) m6A 3'UTR       26404942//27773535 chr5:114951273-114951274(-) m6A 3'UTR       27773535 chr5:114951319-114951320(-) m6A 3'UTR       27773535 chr5:114951347-114951348(-) m6A 3'UTR       27773535 chr5:114951474-114951475(-) m6A 3'UTR       27773535 chr5:114951488-114951489(-) m6A 3'UTR       27773535 chr5:114951545-114951546(-) Y 3'UTR       25219674 chr5:114951554-114951555(-) m6A 3'UTR       27773535 chr5:114951588-114951589(-) m6A 3'UTR       24981863//26404942//27773535 chr5:114951622-114951623(-) m6A 3'UTR       24209618//24981863//26404942//27773535//22608085 chr5:114951708-114951709(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr5:114951716-114951717(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr5:114951746-114951747(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr5:114951758-114951759(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr5:114951831-114951832(-) m6A 3'UTR//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr5:114951931-114951932(-) m6A CDS//exon       24284625//24209618//24981863//26404942//22608085 chr5:114952084-114952085(-) m6A CDS//exon       24284625//24981863//26404942 chr5:114956153-114956154(-) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//22608085 chr5:114956177-114956178(-) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr5:114956208-114956209(-) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr5:114956256-114956257(-) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr5:114956296-114956297(-) m6A CDS//exon       24284625//24981863//26404942//27773535//22608085 chr5:114961334-114961335(-) m6A CDS//intron       24284625//27773535 chr5:114961399-114961400(-) m6A CDS//intron       27773536 chr5:114961539-114961540(-) m6A 5'UTR//intron       27773536//22575960 chr5:114961609-114961610(-) m6A 5'UTR//exon       24284625//24981863//27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-200c-5p	Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Seminal plasma     23539611 Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
	TMED7	Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Membrane K562 cells     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Ribosome HEK-293 cells     22199352 Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-200c-5p
Interactor2: TMED7

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.