Basic Information:

  VIRBase ID:  

HHID00066039

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-200c-5p:  MIMAT0004657          SRRM2:  NM_016333     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-200c-5p	SRRM2
miRBase Accession/Entrez ID	MIMAT0004657	23524
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	300-KD//Cwc21//CWF21//HSPC075//SRL300//SRm300

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-200c-5p	rs1220589670 chr12:6963703    C/T rs1277597787 chr12:6963716    A/C rs372372905 chr12:6963719    G/A rs942672545 chr12:6963713    A/G rs1318673559 chr12:6963704    G/A

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	SRRM2	chr16:2810181(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	SRRM2	chr16:2802507-2802508(+) m6A 5'UTR       - chr16:2802743-2802744(+) m6A 5'UTR//exon       24209618//25456834//27371828//22575960 chr16:2802779-2802780(+) m6A 5'UTR//exon       24209618//25456834//22575960 chr16:2802810-2802811(+) m6A 5'UTR//exon       24209618//25456834//24981863//27371828//22575960 chr16:2803468-2803469(+) m6A 5'UTR//intron       24209618//25456834//24981863//22575960 chr16:2803484-2803485(+) m6A 5'UTR//intron       24209618//25456834//24981863//22575960 chr16:2803528-2803529(+) m6A 5'UTR//intron       24209618//24981863 chr16:2803582-2803583(+) m6A 5'UTR//intron       24209618 chr16:2803601-2803602(+) m6A 5'UTR//intron       24209618 chr16:2803626-2803627(+) m6A 5'UTR//intron       24209618 chr16:2806487-2806488(+) m6A CDS//exon//intron       24284625//24209618//22575960 chr16:2806540-2806541(+) m6A CDS//exon//intron       24284625//24209618//24981863//22575960 chr16:2806587-2806588(+) Gm CDS//exon//intron       - chr16:2807481-2807482(+) m6A 5'UTR//CDS//exon       24284625//24209618//24981863//22575960 chr16:2807540-2807541(+) m6A CDS//exon       24284625//24209618//24981863//22575960 chr16:2807560-2807561(+) m6A CDS//exon       24209618//24981863//22575960 chr16:2807612-2807613(+) m6A exon//intron       24209618//24981863//22575960 chr16:2807661-2807662(+) m6A exon//intron       24981863 chr16:2807832-2807833(+) m6A CDS//exon       22575960 chr16:2807913-2807914(+) m6A CDS//exon       24981863//27773535//22575960 chr16:2807937-2807938(+) m6A CDS//exon       24981863//27773535//22575960 chr16:2808884-2808885(+) m6A exon//intron       24981863//27773535 chr16:2808903-2808904(+) m6A exon//intron       24981863//27773535 chr16:2809031-2809032(+) Am CDS//exon       - chr16:2809387-2809388(+) m6A CDS//exon       24284625//24981863 chr16:2809818-2809819(+) m6A exon//intron       - chr16:2809898-2809899(+) m6A exon//intron       24981863 chr16:2810128-2810129(+) m6A exon//intron       24284625//25456834//24981863//26404942//27773535//22608085 chr16:2810138-2810139(+) m6A exon//intron       24284625//25456834//24981863//26404942//27773535//22608085 chr16:2810323-2810324(+) m6A CDS//exon       22575960 chr16:2810403-2810404(+) m6A CDS//exon       26404942//22575960 chr16:2810443-2810444(+) m6A CDS//exon       24981863//26404942 chr16:2810454-2810455(+) m6A CDS//exon       24981863//26404942 chr16:2810477-2810478(+) m6A CDS//exon       24981863//26404942 chr16:2810489-2810490(+) m6A CDS//exon       24981863//26404942 chr16:2810556-2810557(+) m6A 3'UTR//exon//intron       24981863 chr16:2811614-2811615(+) m6A CDS//exon       24284625//24981863//22575960 chr16:2811703-2811704(+) m6A CDS//exon//intron       24284625//24981863//26404942//27773535//22575960 chr16:2811733-2811734(+) m6A CDS//exon//intron       24284625//24981863//26404942//27773535//22575960 chr16:2811761-2811762(+) m6A CDS//exon//intron       24284625//24981863//26404942//27773535//22575960 chr16:2811854-2811855(+) m6A CDS//exon//intron       24284625//26404942//22575960 chr16:2812023-2812024(+) m6A CDS//exon//intron       24284625//26404942//22575960 chr16:2812257-2812258(+) m6A CDS//intron       24284625//22575960 chr16:2812290-2812291(+) m6A CDS//intron       24284625//22575960 chr16:2812320-2812321(+) m6A CDS//intron       24284625//24981863//22575960 chr16:2812350-2812351(+) m6A CDS//intron       24284625//24981863//22575960 chr16:2812383-2812384(+) m6A CDS//intron       24284625//24981863//22575960 chr16:2812407-2812408(+) m6A CDS//intron       24284625//24981863//22575960 chr16:2812479-2812480(+) m6A CDS//intron       24284625//24981863//22575960//22608085 chr16:2812512-2812513(+) m6A CDS//intron       24284625//24981863//26404942//22575960//22608085 chr16:2812545-2812546(+) m6A CDS//intron       24284625//24981863//26404942//22575960//22608085 chr16:2812581-2812582(+) m6A CDS//intron       24284625//24981863//26404942//22575960//22608085 chr16:2812614-2812615(+) m6A CDS//intron       24284625//24981863//26404942//22575960//22608085 chr16:2812652-2812653(+) Tm CDS//intron       - chr16:2812677-2812678(+) m6A CDS//intron       24981863//26404942//22575960//22608085 chr16:2812723-2812724(+) m6A CDS//intron       24981863//26404942 chr16:2812734-2812735(+) m6A CDS//intron       24981863//26404942 chr16:2812889-2812890(+) m6A CDS//intron       24981863//27773535//22575960 chr16:2812902-2812903(+) m6A CDS//intron       24981863//27773535//22575960//22608085 chr16:2813000-2813001(+) m6A CDS//intron       24981863//27773535//22575960//22608085 chr16:2813013-2813014(+) m6A CDS//intron       24981863//27773535//22575960//22608085 chr16:2813024-2813025(+) m6A CDS//intron       24981863//27773535//22575960//22608085 chr16:2813070-2813071(+) m6A CDS//intron       24981863//26404942//27773535//22575960//22608085 chr16:2813181-2813182(+) m6A CDS//intron       24981863//26404942//22575960//22608085 chr16:2813192-2813193(+) m6A CDS//intron       24981863//26404942//22575960//22608085 chr16:2813246-2813247(+) m6A CDS//intron       24981863//26404942 chr16:2813306-2813307(+) m6A CDS//intron       26404942 chr16:2813468-2813469(+) m6A CDS//intron       24284625//24981863//26404942//27773535//22575960 chr16:2813475-2813476(+) m6A CDS//intron       24284625//24981863//26404942//27773535//22575960 chr16:2813486-2813487(+) m6A CDS//intron       24284625//24981863//26404942//27773535//22575960 chr16:2813535-2813536(+) m6A CDS//intron       24284625//24981863//26404942//27773535//22575960 chr16:2813596-2813597(+) m6A CDS//intron       24284625//24981863//26404942//22575960 chr16:2813705-2813706(+) m6A CDS//intron       24284625//24981863//26404942 chr16:2813715-2813716(+) m6A CDS//intron       24284625//24981863//26404942 chr16:2813725-2813726(+) m6A CDS//intron       24284625//24981863//26404942 chr16:2813759-2813760(+) m6A CDS//intron       24284625//26404942 chr16:2813802-2813803(+) m6A CDS//intron       24284625//26404942//22608085 chr16:2813873-2813874(+) m6A CDS//exon//intron       24284625//24981863//26404942//22575960//22608085 chr16:2813974-2813975(+) m6A CDS//intron       24284625//24981863//26404942//22575960//22608085 chr16:2814009-2814010(+) m6A CDS//intron       24284625//24981863//26404942//22575960//22608085 chr16:2814074-2814075(+) m6A CDS//intron       24284625//24981863//26404942//22575960//22608085 chr16:2814082-2814083(+) m6A CDS//intron       24284625//24981863//26404942//22575960//22608085 chr16:2814139-2814140(+) m6A CDS//intron       24284625//24981863//26404942//22575960//22608085 chr16:2814150-2814151(+) m6A CDS//intron       24284625//24981863//26404942//27773535//22575960//22608085 chr16:2814192-2814193(+) m6A CDS//intron       24284625//24981863//26404942//27773535//22575960//22608085 chr16:2814269-2814270(+) m6A CDS//intron       24284625//24209618//24981863//26404942//27773535//22608085 chr16:2814305-2814306(+) m6A CDS//intron       24284625//24209618//24981863//26404942//27773535//22608085 chr16:2814467-2814468(+) m6A CDS//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr16:2814476-2814477(+) m6A CDS//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr16:2814502-2814503(+) m6A CDS//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr16:2814532-2814533(+) m6A CDS//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr16:2814599-2814600(+) m6A CDS//intron       24284625//24209618//24981863//26404942//22608085 chr16:2814621-2814622(+) m6A CDS//intron       24284625//24209618//24981863//26404942//22608085 chr16:2814637-2814638(+) m6A CDS//intron       24284625//26404942//22608085 chr16:2814647-2814648(+) m6A CDS//intron       24284625//26404942//22608085 chr16:2814668-2814669(+) m6A CDS//intron       24284625//26404942//22608085 chr16:2814765-2814766(+) m6A CDS//intron       26404942//22575960 chr16:2814828-2814829(+) m6A CDS//intron       24981863//26404942//22575960 chr16:2814866-2814867(+) m6A CDS//exon//intron       24284625//24981863//26404942//22575960 chr16:2814885-2814886(+) m6A CDS//exon//intron       24284625//24981863//26404942//22575960 chr16:2814983-2814984(+) m6A CDS//exon//intron       24284625//24981863//26404942//22575960 chr16:2815002-2815003(+) m6A CDS//exon//intron       24284625//24981863//26404942//22575960 chr16:2815107-2815108(+) m6A CDS//exon//intron       24284625//24981863//26404942//27773535//22575960//22608085 chr16:2815119-2815120(+) m6A CDS//exon//intron       24284625//24981863//26404942//27773535//22575960//22608085 chr16:2815160-2815161(+) m6A CDS//exon//intron       24284625//24981863//26404942//22575960//22608085 chr16:2815172-2815173(+) m6A CDS//exon//intron       24284625//24981863//26404942//22575960//22608085 chr16:2815207-2815208(+) m6A CDS//exon//intron       24284625//24981863//26404942//22575960//22608085 chr16:2815233-2815234(+) m6A CDS//exon//intron       24284625//24981863//26404942//22575960//22608085 chr16:2815239-2815240(+) m6A CDS//exon//intron       24284625//24981863//26404942//22575960//22608085 chr16:2815342-2815343(+) Am CDS//exon//intron       - chr16:2815397-2815398(+) m6A CDS//intron       24284625//26404942//22575960 chr16:2815508-2815509(+) m6A CDS//intron       24284625//24981863//26404942//27773535//22575960 chr16:2815527-2815528(+) m6A CDS//intron       24284625//24981863//26404942//27773535//22575960 chr16:2815566-2815567(+) m6A CDS//intron       24284625//24981863//26404942//22575960 chr16:2815634-2815635(+) m6A CDS//intron       24284625//24981863//26404942//22575960 chr16:2815674-2815675(+) m6A CDS//intron       24284625//24981863//22575960 chr16:2815686-2815687(+) m6A CDS//intron       24284625//24981863//22575960 chr16:2815791-2815792(+) m6A CDS//intron       24284625//24981863//22575960 chr16:2815835-2815836(+) m6A CDS//intron       24284625//24981863//22575960 chr16:2815872-2815873(+) m6A CDS//intron       24284625//22575960 chr16:2815878-2815879(+) m6A CDS//intron       24284625//22575960 chr16:2815931-2815932(+) m6A CDS//intron       24284625//22575960 chr16:2816025-2816026(+) m6A CDS//intron       24284625//22575960 chr16:2816058-2816059(+) m6A CDS//intron       24284625//22575960 chr16:2816166-2816167(+) m6A CDS//intron       24284625//22575960 chr16:2816202-2816203(+) m6A CDS//intron       24284625//22575960 chr16:2816238-2816239(+) m6A CDS//intron       24284625//26404942//22575960 chr16:2816255-2816256(+) Am CDS//intron       - chr16:2816376-2816377(+) m6A CDS//intron       24284625//26404942//22575960 chr16:2816412-2816413(+) m6A CDS//intron       24284625//26404942//22575960 chr16:2816448-2816449(+) m6A CDS//intron       24284625//26404942//22575960 chr16:2816484-2816485(+) m6A CDS//intron       24284625//22575960 chr16:2816556-2816557(+) m6A CDS//intron       24284625//22575960 chr16:2816592-2816593(+) m6A CDS//intron       24284625//22575960 chr16:2816709-2816710(+) m6A CDS//intron       24284625//22575960 chr16:2816838-2816839(+) m6A CDS//intron       24284625//26404942//22575960 chr16:2816939-2816940(+) m6A CDS//intron       24284625//24981863//26404942//22575960//22608085 chr16:2816958-2816959(+) m6A CDS//intron       24284625//24981863//26404942//22575960//22608085 chr16:2817036-2817037(+) m6A CDS//intron       24284625//24981863//26404942//22575960//22608085 chr16:2817161-2817162(+) Y CDS       25219674 chr16:2817192-2817193(+) m6A CDS//intron       24284625//24981863//26404942//22575960//22608085 chr16:2817250-2817251(+) m6A CDS//intron       24284625//25456834//24981863//26404942//22575960//22608085 chr16:2817267-2817268(+) m6A CDS//intron       24284625//25456834//24981863//26404942//22575960//22608085 chr16:2817292-2817293(+) m6A CDS//intron       24284625//25456834//24981863//26404942//22575960//22608085 chr16:2817334-2817335(+) m6A CDS//intron       24284625//25456834//24981863//26404942//22575960//22608085 chr16:2817351-2817352(+) m6A CDS//intron       24284625//25456834//24981863//26404942//22575960//22608085 chr16:2817376-2817377(+) m6A CDS//intron       24284625//25456834//24981863//26404942//22575960//22608085 chr16:2817415-2817416(+) m6A CDS//intron       24284625//25456834//24981863//26404942//22575960//22608085 chr16:2817432-2817433(+) m6A CDS//intron       24284625//25456834//24981863//26404942//22575960//22608085 chr16:2817493-2817494(+) m6A CDS//intron       24284625//25456834//24981863//26404942//22575960//22608085 chr16:2817513-2817514(+) m6A CDS//exon//intron       24284625//25456834//24981863//26404942//22575960//22608085 chr16:2817538-2817539(+) m6A CDS//exon//intron       24284625//25456834//24981863//26404942//22575960//22608085 chr16:2817597-2817598(+) m6A CDS//exon//intron       24284625//24981863//22575960 chr16:2817664-2817665(+) m6A CDS//exon//intron       24284625//25456834//24981863//26404942//22575960 chr16:2817717-2817718(+) m6A CDS//exon//intron       24284625//25456834//24981863//26404942//22575960 chr16:2817753-2817754(+) m6A CDS//exon//intron       24284625//25456834//24981863//26404942//22575960 chr16:2817898-2817899(+) m6A CDS//exon//intron       24284625//22575960 chr16:2817924-2817925(+) m6A CDS//exon//intron       24284625//22575960 chr16:2818508-2818509(+) m6A CDS//exon//intron       24284625//24209618//24981863//22575960 chr16:2818513-2818514(+) m6A CDS//exon//intron       24284625//24209618//24981863//22575960 chr16:2818527-2818528(+) m6A 3'UTR//exon//intron       24284625//24209618//24981863//22575960 chr16:2818560-2818561(+) m6A 3'UTR//exon//intron       24284625//24209618//24981863//22575960 chr16:2818572-2818573(+) m6A 3'UTR//exon//intron       24284625//24209618//24981863//22575960 chr16:2818701-2818702(+) m6A exon//intron       24284625//24981863//22575960 chr16:2818757-2818758(+) m6A exon//intron       24284625 chr16:2819246-2819247(+) m6A 3'UTR//CDS//exon//intron       24284625//24981863//22575960 chr16:2819493-2819494(+) m6A exon//intron       24284625//22575960 chr16:2819683-2819684(+) m6A exon//intron       24284625//25456834//24981863//22575960//22608085 chr16:2819756-2819757(+) m6A exon//intron       24284625//25456834//24981863//22575960 chr16:2819906-2819907(+) m6A exon//intron       24284625//24981863 chr16:2819950-2819951(+) m6A exon//intron       24284625//25456834//24981863//22575960 chr16:2819967-2819968(+) m6A exon//intron       24284625//25456834//24981863//22575960 chr16:2819979-2819980(+) m6A exon//intron       24284625//25456834//24981863//22575960 chr16:2819996-2819997(+) m6A exon//intron       24284625//25456834//24981863//22575960 chr16:2820131-2820132(+) m6A exon//intron       24284625//24981863//22575960 chr16:2820222-2820223(+) m6A exon//intron       24284625//24981863//22575960 chr16:2820274-2820275(+) m6A exon//intron       - chr16:2820378-2820379(+) m6A CDS//exon//intron       24284625//22575960 chr16:2820390-2820391(+) m6A CDS//exon//intron       24284625//24981863//22575960 chr16:2820456-2820457(+) m6A CDS//exon//intron       24284625//24981863//27371828//22575960 chr16:2820645-2820646(+) m6A CDS//exon//intron       24284625//24981863//27371828//22575960 chr16:2820680-2820681(+) m6A CDS//exon//intron       24284625//24981863//27371828//22575960 chr16:2820703-2820704(+) m6A CDS//exon//intron       24284625//24981863//22575960 chr16:2821224-2821225(+) m6A 3'UTR//exon//intron       26404942//27773535 chr16:2821308-2821309(+) m6A 3'UTR//CDS//exon//intron       27773535 chr16:2821412-2821413(+) m6A 3'UTR//exon       27773535 chr16:2821425-2821426(+) m6A exon       27773535 chr16:2821494-2821495(+) m6A exon       27773535 chr16:2821529-2821530(+) m6A exon       27773535 chr16:2821541-2821542(+) m6A exon       27773535 chr16:2821547-2821548(+) m6A exon       27773535 chr16:2821596-2821597(+) m6A exon       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-200c-5p	Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Seminal plasma     23539611 Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
	SRRM2	Chromatin K562 cells     - Cytosol HeLa-S3 cells|K562 cells     - Exosome Blood     - Membrane K562 cells     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus Colon cancer cells     24393600 Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-200c-5p
Interactor2: SRRM2

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	CDS
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.