Detail Information

Basic Information:


  VIRBase ID:  

HHID00066038

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-200c-5p:           SUMO3:      

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Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-200c-5p SUMO3
miRBase
Accession/Entrez ID		 MIMAT0004657 6612
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - SMT3A//Smt3B//SMT3H1//SUMO-3

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-200c-5p
rs1220589670 chr12:6963703    C/T
rs1277597787 chr12:6963716    A/C
rs372372905 chr12:6963719    G/A
rs942672545 chr12:6963713    A/G
rs1318673559 chr12:6963704    G/A

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR SUMO3
chr21:46228328(-) A-I      Syn:Ser->Ser
chr21:46232087(-) A-I      intronic
chr21:46232100(-) A-I      intronic
chr21:46231392(-) A-I      intronic
chr21:46231473(-) A-I      intronic
chr21:46232096(-) A-I      intronic
chr21:46232213(-) A-I      intronic
chr21:46232176(-) A-I      intronic
chr21:46231306(-) A-I      intronic
chr21:46232172(-) A-I      intronic
chr21:46231330(-) A-I      intronic
chr21:46231375(-) A-I      intronic
chr21:46231460(-) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase SUMO3
chr21:46226204-46226205(-) m6A 3'UTR//exon       -
chr21:46226713-46226714(-) m6A 3'UTR//exon       24981863//27773535
chr21:46226766-46226767(-) m6A 3'UTR//exon       24981863//27371828//27773536
chr21:46226774-46226775(-) m6A 3'UTR//exon       24981863//27371828//27773536
chr21:46226935-46226936(-) m6A CDS//exon       24209618//27773535//27371828//27773536//22575960
chr21:46228308-46228309(-) m6A CDS//intron       -
chr21:46228978-46228979(-) m6A CDS//exon       27773535//27371828//27773536//22575960
chr21:46233465-46233466(-) m6A exon//intron       27773535//27371828//27773536//22575960
chr21:46233946-46233947(-) Am CDS//exon       -
chr21:46234006-46234007(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-200c-5p
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Seminal plasma     23539611
Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
SUMO3
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleolus K562 cells     -
Ribosome HEK-293 cells     22199352
Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-200c-5p
Interactor2: SUMO3

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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