Detail Information

Basic Information:


  VIRBase ID:  

HHID00066035

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-200c-5p:           MCL1:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-200c-5p MCL1
miRBase
Accession/Entrez ID		 MIMAT0004657 4170
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - bcl2-L-3//BCL2L3//EAT//Mcl-1//MCL1-ES//mcl1/EAT//MCL1L//MCL1S//TM

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-200c-5p
rs1220589670 chr12:6963703    C/T
rs1277597787 chr12:6963716    A/C
rs372372905 chr12:6963719    G/A
rs942672545 chr12:6963713    A/G
rs1318673559 chr12:6963704    G/A

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase MCL1
chr1:150547166-150547167(-) Y 3'UTR       25219674
chr1:150547424-150547425(-) m6A 3'UTR       24981863//26404942
chr1:150547472-150547473(-) m6A 3'UTR       26404942
chr1:150547590-150547591(-) Y 3'UTR       25219674
chr1:150547632-150547633(-) m6A 3'UTR       26404942
chr1:150547747-150547748(-) m6A 3'UTR       26404942
chr1:150547800-150547801(-) m6A 3'UTR       26404942
chr1:150547820-150547821(-) m6A 3'UTR       26404942
chr1:150547851-150547852(-) m6A 3'UTR       26404942
chr1:150547875-150547876(-) m6A 3'UTR       26404942
chr1:150547902-150547903(-) m6A 3'UTR       26404942
chr1:150547985-150547986(-) m6A 3'UTR       26404942
chr1:150548068-150548069(-) m6A 3'UTR       26404942
chr1:150548154-150548155(-) m6A 3'UTR       26404942
chr1:150548172-150548173(-) m6A 3'UTR       26404942
chr1:150548209-150548210(-) m6A 3'UTR       26404942
chr1:150548222-150548223(-) m6A 3'UTR       26404942
chr1:150548589-150548590(-) m6A 3'UTR       24981863//26404942
chr1:150548638-150548639(-) m6A 3'UTR       26404942
chr1:150549312-150549313(-) m6A 3'UTR       26404942
chr1:150549407-150549408(-) m6A 3'UTR//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr1:150549533-150549534(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr1:150549538-150549539(-) Y 3'UTR//exon       25219674
chr1:150549553-150549554(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr1:150549588-150549589(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr1:150549619-150549620(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr1:150549692-150549693(-) Tm 3'UTR//exon       -
chr1:150549779-150549780(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr1:150549797-150549798(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr1:150549935-150549936(-) m6A CDS//exon       24284625//24209618//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr1:150550731-150550732(-) m6A CDS//exon//intron       24284625//24209618//24981863//26404942//27773535//27371828//27773536//22575960//22608085
chr1:150550744-150550745(-) m6A CDS//exon//intron       24284625//24209618//24981863//26404942//27773535//27371828//27773536//22575960//22608085
chr1:150550754-150550755(-) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//26404942//27773535//27371828//27773536//22575960//22608085
chr1:150550791-150550792(-) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr1:150550810-150550811(-) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr1:150550817-150550818(-) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr1:150550827-150550828(-) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr1:150550876-150550877(-) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr1:150550948-150550949(-) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr1:150550953-150550954(-) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr1:150550989-150550990(-) m6A exon//intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr1:150551007-150551008(-) m6A exon//intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr1:150551235-150551236(-) m6A exon//intron       24284625//24209618//25456834//24981863//26404942//27773535//27371828//27773536//22575960//22608085
chr1:150551372-150551373(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr1:150551422-150551423(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr1:150551449-150551450(-) Y CDS       26075521
chr1:150551791-150551792(-) m6A CDS//intron       24284625//24209618//25456834//24981863//27371828//27773536//22575960
chr1:150551973-150551974(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr1:150552109-150552110(-) m6A 5'UTR       -
chr1:150552124-150552125(-) m6A 5'UTR       -

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-200c-5p
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Seminal plasma     23539611
Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
MCL1
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol HCC cell line (HepG2)     -
Exosome Blood     -
Nucleolus K562 cells     -
Nucleus Nasopharyngeal carcinoma cells     20498841
Nucleus Nasopharyngeal carcinoma cells     20498841
Nucleus HeLa-S3 cells     -
Ribosome HEK-293 cells     22199352
Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-200c-5p
Interactor2: MCL1

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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