Detail Information

Basic Information:


  VIRBase ID:  

HHID00066000

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.9092

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-146a-3p:           CXCR4:      

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Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-146a-3p CXCR4
miRBase
Accession/Entrez ID		 MIMAT0004608 7852
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - CD184//D2S201E//FB22//HM89//HSY3RR//LAP-3//LAP3//LCR1//LESTR//NPY3R//NPYR//NPYRL//NPYY3R//WHIM//WHIMS

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-146a-3p
rs1323710653 chr5:160485408    C/T
rs1343966428 chr5:160485421    G/C
rs529455292 chr5:160485429    G/T
rs772931224 chr5:160485420    A/G
rs1173033188 chr5:160485411    CT/C
rs1234876154 chr5:160485413    G/GA
rs2910164 chr5:160485411    C/G

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase CXCR4
chr2:136872173-136872174(-) m6A 3'UTR       24284625//26404942
chr2:136872178-136872179(-) m6A 3'UTR       24284625//26404942
chr2:136872193-136872194(-) m6A 3'UTR       24284625//26404942
chr2:136872235-136872236(-) m6A 3'UTR//exon       24284625//26404942
chr2:136872364-136872365(-) m6A 3'UTR//exon       24284625//26404942//27773535
chr2:136872423-136872424(-) m6A 3'UTR//exon       24284625//25456834//24981863//26404942//27773535//27371828//22608085
chr2:136872489-136872490(-) m6A CDS//exon       24284625//24981863//26404942//27773535//27371828//22575960//22608085
chr2:136872566-136872567(-) m6A CDS//exon       24284625//24981863//26404942//27773535//27371828//22575960//22608085
chr2:136872604-136872605(-) m6A CDS//exon       24284625//24981863//26404942//27773535//27371828//22575960//22608085
chr2:136872664-136872665(-) m6A CDS//exon       24284625//24981863//26404942//27773535//22575960//22608085
chr2:136872779-136872780(-) m6A CDS//exon       24284625//24981863//27773535//22575960//22608085
chr2:136873099-136873100(-) m6A CDS//exon       24284625//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr2:136873180-136873181(-) m6A CDS//exon       24284625//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr2:136873195-136873196(-) m6A CDS//exon       24284625//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr2:136873276-136873277(-) m6A CDS//exon       24284625//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr2:136873293-136873294(-) m6A CDS//exon       24284625//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr2:136873419-136873420(-) m6A CDS//exon       24284625//24981863//28052920//27773535//27371828//22575960//22608085
chr2:136873438-136873439(-) m6A CDS//exon       24284625//24981863//27773535//27371828//22575960//22608085
chr2:136875257-136875258(-) m6A exon//intron       24284625
chr2:136875263-136875264(-) m6A exon//intron       24284625
chr2:136875642-136875643(-) m6A 5'UTR       24284625//24981863//27371828
chr2:136875723-136875724(-) m6A 5'UTR       24284625//24981863//27371828

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-146a-3p
Exosome Plasma     23663360
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Mesenchymal stem cells     -
CXCR4
Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleus HeLa-S3 cells     -
Ribosome HEK-293 cells     22199352

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-146a-3p
Interactor2: CXCR4

Evidence Support:


Strong-Evidence qRT-PCR//Western blot
Prediction-Evidence DIANA//miRDB//StarBase
Support Database ViRBase

References:


PMID 31299195 Target region 3'UTR
Source ViRBase Interactor1 expression Upregulation
Tissue or cell line GT39 cells//SGC7901 cells Interactor2 expression None
Description MiR-146a down-regulated CXCR4 expression in a dose- and time-dependent manner.

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