Basic Information:

  VIRBase ID:  

HHID00065990

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-138-1-3p:  MIMAT0004607          POLE3:  NR_027261     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-138-1-3p	POLE3
miRBase Accession/Entrez ID	MIMAT0004607	54107
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	CHARAC17//CHRAC17//CHRAC2//p17//YBL1

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-138-1-3p	rs1215016527 chr3:44114288    C/T rs759234321 chr3:44114292    G/A rs759234321 chr3:44114292    G/C rs770499543 chr3:44114276    T/C rs773680447 chr3:44114278    C/A rs892673276 chr3:44114281    C/T

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	POLE3	chr9:116170202-116170203(-) m6A 3'UTR//exon       24284625//27773535 chr9:116170248-116170249(-) m6A 3'UTR//exon       24284625//27773535 chr9:116170923-116170924(-) m6A 3'UTR//exon       24284625//24209618//24981863//28052920//26404942//27773535//27371828//22608085 chr9:116170938-116170939(-) m6A 3'UTR//exon       24284625//24209618//24981863//28052920//26404942//27773535//27371828//22608085 chr9:116170960-116170961(-) m6A 3'UTR//exon       24284625//24209618//24981863//28052920//26404942//27773535//27371828//22608085 chr9:116171077-116171078(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085 chr9:116171097-116171098(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085 chr9:116171103-116171104(-) m1A CDS//exon       26863196 chr9:116171120-116171121(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085 chr9:116171127-116171128(-) m1A CDS//exon       26863196 chr9:116171157-116171158(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085 chr9:116171175-116171176(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085 chr9:116171194-116171195(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085 chr9:116171202-116171203(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085 chr9:116171208-116171209(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085 chr9:116171212-116171213(-) m1A CDS//exon       26863196 chr9:116172043-116172044(-) m6A exon//intron       24981863//27773535 chr9:116172547-116172548(-) m6A CDS//exon       24284625//24981863//27371828//22575960 chr9:116172553-116172554(-) m6A CDS//exon       24284625//24981863//27371828//22575960 chr9:116172651-116172652(-) m6A 5'UTR       24284625//25456834//24981863//27371828//27773536//22575960//22608085 chr9:116172666-116172667(-) m6A 5'UTR       24284625//25456834//24981863//27371828//27773536//22575960//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-138-1-3p	Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Fibroblasts|Mesenchymal stem cells     -
	POLE3	Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleoplasm K562 cells     - Nucleus Nasopharyngeal carcinoma cells     20498841 Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-138-1-3p
Interactor2: POLE3

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.