Basic Information:

  VIRBase ID:  

HHID00065949

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-143-5p:  MIMAT0004599          CEP44:  NM_001040157     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-143-5p	CEP44
miRBase Accession/Entrez ID	MIMAT0004599	80817
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	KIAA1712//PS1TP3

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-143-5p	rs1240622815 chr5:149428959    C/T rs1379718357 chr5:149428964    G/A rs747639742 chr5:149428962    T/C rs1440810125 chr5:149428950    G/A

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	CEP44	chr4:175233559(+) A-I      intronic chr4:175251408(+) A-I      intronic chr4:175250337(+) A-I      intronic chr4:175250202(+) A-I      intronic chr4:175250159(+) A-I      intronic chr4:175246597(+) A-I      intronic chr4:175233496(+) A-I      intronic chr4:175233488(+) A-I      intronic chr4:175226462(+) A-I      intronic chr4:175239356(+) A-I      3'UTR chr4:175239332(+) A-I      3'UTR chr4:175239314(+) A-I      3'UTR chr4:175239315(+) A-I      3'UTR chr4:175246771(+) A-I      intronic chr4:175246623(+) A-I      intronic chr4:175250153(+) A-I      intronic chr4:175246691(+) A-I      intronic chr4:175250227(+) A-I      intronic chr4:175250231(+) A-I      intronic chr4:175240147(+) A-I      3'UTR chr4:175250116(+) A-I      intronic chr4:175246549(+) A-I      intronic chr4:175246664(+) A-I      intronic chr4:175246761(+) A-I      intronic chr4:175250299(+) A-I      intronic chr4:175251384(+) A-I      intronic chr4:175250237(+) A-I      intronic chr4:175233502(+) A-I      intronic chr4:175250198(+) A-I      intronic chr4:175211273(+) A-I      intronic chr4:175236858(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	CEP44	chr4:175246549(+) A-I intron -    22327324 chr4:175239285(+) G-A intron -    22484847 chr4:175246549(+) A-G intron -    22484847 chr4:175246664(+) A-G intron -    22484847 chr4:175246691(+) A-G intron -    22484847 chr4:175246771(+) A-G intron -    22484847 chr4:175250116(+) A-G intron -    22484847 chr4:175250151(+) A-G intron -    22484847 chr4:175250153(+) A-G intron -    22484847 chr4:175250227(+) A-G intron -    22484847 chr4:175250299(+) A-G intron -    22484847 chr4:175250336(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	CEP44	chr4:175204946-175204947(+) m6A 5'UTR       24981863 chr4:175204972-175204973(+) m6A 5'UTR       24981863 chr4:175205111-175205112(+) m6A 5'UTR//intron       24981863 chr4:175205198-175205199(+) m6A 5'UTR//intron       24209618//24981863//22608085 chr4:175238495-175238496(+) m6A CDS//intron       24981863 chr4:175238872-175238873(+) m6A 3'UTR//intron       24981863 chr4:175238896-175238897(+) m6A 3'UTR//intron       24981863 chr4:175238910-175238911(+) m6A 3'UTR//intron       24981863 chr4:175240837-175240838(+) Y 3'UTR//intron       26075521 chr4:175252883-175252884(+) m6A 3'UTR       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-143-5p	Exosome Breast milk     22211110 Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Fibroblasts|Mesenchymal stem cells     -
	CEP44	Chromatin K562 cells     - Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)     - Exosome Blood     - Nucleoplasm K562 cells     - Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus HCC cell line (HepG2)|K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-143-5p
Interactor2: CEP44

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	CDS
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.