Basic Information:

  VIRBase ID:  

HHID00065905

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-143-5p:  MIMAT0004599          TRAF4:  NM_004295     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-143-5p	TRAF4
miRBase Accession/Entrez ID	MIMAT0004599	9618
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	CART1//MLN62//RNF83

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-143-5p	rs1240622815 chr5:149428959    C/T rs1379718357 chr5:149428964    G/A rs747639742 chr5:149428962    T/C rs1440810125 chr5:149428950    G/A

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	TRAF4	chr17:27073892(+) A-I      intronic chr17:27072836(+) A-I      intronic chr17:27072866(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	TRAF4	chr17:27072360-27072361(+) m6A 3'UTR//intron       24284625 chr17:27072405-27072406(+) m6A 3'UTR//intron       24284625 chr17:27074805-27074806(+) m6A exon//intron       24284625 chr17:27074870-27074871(+) m6A 3'UTR//5'UTR//CDS//exon//intron       24284625 chr17:27075604-27075605(+) m6A 3'UTR//CDS//exon//intron       22575960 chr17:27075625-27075626(+) m6A 3'UTR//CDS//exon//intron       22575960 chr17:27075664-27075665(+) m6A 3'UTR//CDS//exon//intron       24981863//22575960 chr17:27075733-27075734(+) m6A exon//intron       24981863//22575960 chr17:27076381-27076382(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr17:27076400-27076401(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr17:27076419-27076420(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr17:27076512-27076513(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr17:27076527-27076528(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr17:27076570-27076571(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr17:27076656-27076657(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr17:27076674-27076675(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr17:27076784-27076785(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//22575960 chr17:27076813-27076814(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//26404942//22575960 chr17:27076855-27076856(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942//22575960 chr17:27076887-27076888(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942 chr17:27077153-27077154(+) m6A 3'UTR       24284625//25456834 chr17:27077171-27077172(+) m6A 3'UTR       24284625//25456834 chr17:27077255-27077256(+) m6A 3'UTR       24284625//25456834//24981863 chr17:27077469-27077470(+) m6A 3'UTR       24981863//26404942//22608085 chr17:27077590-27077591(+) m6A 3'UTR       24284625 chr17:27077609-27077610(+) m6A 3'UTR       24284625

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-143-5p	Exosome Breast milk     22211110 Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Fibroblasts|Mesenchymal stem cells     -
	TRAF4	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol K562 cells     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     - Ribosome HEK-293 cells     22199352 Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-143-5p
Interactor2: TRAF4

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	CDS
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.