Basic Information:

  VIRBase ID:  

HHID00065871

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-140-3p:  MIMAT0004597          MED28:  NM_025205     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-140-3p	MED28
miRBase Accession/Entrez ID	MIMAT0004597	80306
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	1500003D12Rik//EG1//magicin

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-140-3p	rs111366342 chr16:69933159    A/G rs1403836350 chr16:69933150    G/A rs771611815 chr16:69933160    C/T rs772662673 chr16:69933161    G/A

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	MED28	chr4:17619721(+) A-I      intronic chr4:17619696(+) A-I      intronic chr4:17620203(+) A-I      intronic chr4:17619821(+) A-I      intronic chr4:17619866(+) A-I      intronic chr4:17620179(+) A-I      intronic chr4:17620233(+) A-I      intronic chr4:17620315(+) A-I      intronic chr4:17620346(+) A-I      intronic chr4:17619752(+) A-I      intronic chr4:17620243(+) A-I      intronic chr4:17619378(+) A-I      intronic chr4:17617723(+) A-I      intronic chr4:17619354(+) A-I      intronic chr4:17617710(+) A-I      intronic chr4:17617647(+) A-I      intronic chr4:17619419(+) A-I      intronic chr4:17619415(+) A-I      intronic chr4:17619375(+) A-I      intronic chr4:17619784(+) A-I      intronic chr4:17619499(+) A-I      intronic chr4:17619409(+) A-I      intronic chr4:17619480(+) A-I      intronic chr4:17619344(+) A-I      intronic chr4:17617683(+) A-I      intronic chr4:17622230(+) A-I      intronic chr4:17617763(+) A-I      intronic chr4:17620269(+) A-I      intronic chr4:17619683(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	MED28	chr4:17617647(+) A-G intron -    22484847 chr4:17617648(+) A-G intron -    22484847 chr4:17617683(+) A-G intron -    22484847 chr4:17617684(+) A-G intron -    22484847 chr4:17617710(+) A-G intron -    22484847 chr4:17620269(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	MED28	chr4:17616275-17616276(+) m6A 5'UTR//exon       24284625//25456834//24981863 chr4:17616390-17616391(+) m6A CDS//exon       24981863 chr4:17625317-17625318(+) m6A CDS       24284625//22575960//22608085 chr4:17625491-17625492(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr4:17625509-17625510(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//22608085 chr4:17625626-17625627(+) m6A 3'UTR//intron       24981863 chr4:17626304-17626305(+) m6A 3'UTR//intron       - chr4:17626352-17626353(+) m6A 3'UTR//intron       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-140-3p	Exosome HCC tissues     30542726 Exosome Primary dendritic cells|T cell line (J77)     21505438 Exosome Breast milk     22211110 Exosome Plasma     23663360 Exosome Colon cancer cell line (LIM1863)     25330373 Exosome Blood|B lymphoblastoid cells|Breast milk|Colon tissue|Endothelial cells|Epithelial cells|Lymphoma tissue|Mast cells|Seminal fluid|Tongue tissue     - Microvesicle Plasma     23077538 Microvesicle Seminal plasma     23539611 Microvesicle Follicular fluid     23666971 Microvesicle Hepatoma cells     23771658 Microvesicle Blood|Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     - Mitochondrion Skeletal muscle myoblasts     21637849 Mitochondrion Cell line (HEK-293|HeLa)     22984580
	MED28	Chromatin K562 cells     - Cytosol HeLa-S3 cells     - Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HeLa-S3 cells|K562 cells     - Ribosome HEK-293 cells     22199352 Ribosome Colon cancer cells     24393600

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-140-3p	5-Fluorouracil 3385 Drug interaction    RC00006941

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-140-3p	Cisplatin 5702198       30980798 Paclitaxel 36314       30980798 Doxorubicin 31703       25698578 Doxorubicin 31703       30980798

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	hsa-miR-140-3p	Panobinostat       6918837 Topotecan       60700 l-685,458       5479543

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-140-3p
Interactor2: MED28

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.