Detail Information

Basic Information:


  VIRBase ID:  

HHID00065868

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-140-3p:           TM9SF3:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-140-3p TM9SF3
miRBase
Accession/Entrez ID		 MIMAT0004597 56889
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - EP70-P-iso//SMBP

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-140-3p
rs111366342 chr16:69933159    A/G
rs1403836350 chr16:69933150    G/A
rs771611815 chr16:69933160    C/T
rs772662673 chr16:69933161    G/A

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR TM9SF3
chr10:98300788(-) A-I      intronic
chr10:98300785(-) A-I      intronic
chr10:98300794(-) A-I      intronic
chr10:98300793(-) A-I      intronic
chr10:98329677(-) A-I      intronic
chr10:98323987(-) A-I      intronic
chr10:98340218(-) A-I      intronic
chr10:98330623(-) A-I      intronic
chr10:98322887(-) A-I      intronic
chr10:98322956(-) A-I      intronic
chr10:98340083(-) A-I      intronic
chr10:98330768(-) A-I      intronic
chr10:98340207(-) A-I      intronic
chr10:98338622(-) A-I      intronic
chr10:98338665(-) A-I      intronic
chr10:98338671(-) A-I      intronic
chr10:98323927(-) A-I      intronic
chr10:98344403(-) A-I      intronic
chr10:98322961(-) A-I      intronic
chr10:98330751(-) A-I      intronic
chr10:98340204(-) A-I      intronic
chr10:98338715(-) A-I      intronic
chr10:98323981(-) A-I      intronic
chr10:98296651(-) A-I      intronic
chr10:98300777(-) A-I      intronic
chr10:98340290(-) A-I      intronic
chr10:98340194(-) A-I      intronic
chr10:98338751(-) A-I      intronic
chr10:98340228(-) A-I      intronic
chr10:98340226(-) A-I      intronic
chr10:98323997(-) A-I      intronic
chr10:98338788(-) A-I      intronic
chr10:98338661(-) A-I      intronic
chr10:98297494(-) A-I      intronic
chr10:98340161(-) A-I      intronic
chr10:98328826(-) A-I      intronic
chr10:98329689(-) A-I      intronic
chr10:98338676(-) A-I      intronic
chr10:98330635(-) A-I      intronic
chr10:98338777(-) A-I      intronic
chr10:98338722(-) A-I      intronic
chr10:98329626(-) A-I      intronic
chr10:98340056(-) A-I      intronic
chr10:98297506(-) A-I      intronic
chr10:98338667(-) A-I      intronic
chr10:98297473(-) A-I      intronic
chr10:98329546(-) A-I      intronic
chr10:98332390(-) A-I      intronic
chr10:98323937(-) A-I      intronic
chr10:98338653(-) A-I      intronic
chr10:98323271(-) A-I      intronic
chr10:98340187(-) A-I      intronic
chr10:98322971(-) A-I      intronic
chr10:98299011(-) A-I      intronic
chr10:98298985(-) A-I      intronic
chr10:98328845(-) A-I      intronic
chr10:98342664(-) A-I      intronic
chr10:98340287(-) A-I      intronic
chr10:98344409(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED TM9SF3
chr10:98320668(-) A-I intron -    22327324
chr10:98296691(-) A-I intron -    21960545
chr10:98296716(-) A-I intron -    21960545
chr10:98322971(-) A-I intron -    21960545
chr10:98323937(-) A-I intron -    21960545
chr10:98323997(-) A-I intron -    21960545
chr10:98338621(-) A-I intron -    21960545
chr10:98338712(-) A-I intron -    21960545
chr10:98338722(-) A-I intron -    21960545
chr10:98338777(-) A-I intron -    21960545
chr10:98322971(-) A-G intron -    22484847
chr10:98340161(-) A-G intron -    22484847
chr10:98343775(-) C-T intron -    22484847
chr10:98281484(-) T-C exon 3'UTR    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase TM9SF3
chr10:98278050-98278051(-) m6A 3'UTR       24981863//22608085
chr10:98278075-98278076(-) m6A 3'UTR       24981863//22608085
chr10:98278106-98278107(-) m6A 3'UTR       24981863//22608085
chr10:98278149-98278150(-) m6A 3'UTR       22608085
chr10:98278157-98278158(-) m6A 3'UTR       22608085
chr10:98280601-98280602(-) m6A 3'UTR       -
chr10:98280623-98280624(-) m6A 3'UTR       -
chr10:98280646-98280647(-) m6A 3'UTR       -
chr10:98281033-98281034(-) Cm 3'UTR       -
chr10:98281112-98281113(-) m6A 3'UTR       26404942
chr10:98281319-98281320(-) m6A 3'UTR       26404942
chr10:98281367-98281368(-) m6A 3'UTR       26404942
chr10:98281394-98281395(-) m6A 3'UTR       26404942
chr10:98281529-98281530(-) m6A 3'UTR       26404942
chr10:98281659-98281660(-) m6A 3'UTR       26404942
chr10:98281708-98281709(-) m6A 3'UTR       24284625//26404942
chr10:98281731-98281732(-) m6A 3'UTR       24284625//22608085
chr10:98281755-98281756(-) m6A 3'UTR       24284625//22608085
chr10:98281951-98281952(-) m6A 3'UTR       24284625//25456834//24981863//28052920//26404942//27371828//22575960//22608085
chr10:98281966-98281967(-) m6A 3'UTR       24284625//25456834//24981863//28052920//26404942//27371828//22575960//22608085
chr10:98281999-98282000(-) m6A 3'UTR       24284625//25456834//24981863//28052920//26404942//27371828//22575960//22608085
chr10:98282006-98282007(-) m6A 3'UTR       24284625//25456834//24981863//28052920//26404942//27371828//22575960//22608085
chr10:98282016-98282017(-) m6A 3'UTR       24284625//25456834//24981863//28052920//26404942//27371828//22575960//22608085
chr10:98282066-98282067(-) m6A CDS//exon       24284625//24981863//26404942//27371828//22608085
chr10:98321836-98321837(-) m6A CDS//exon       26404942
chr10:98321847-98321848(-) m6A CDS//exon       26404942
chr10:98336381-98336382(-) m6A exon//intron       26404942
chr10:98336453-98336454(-) m6A CDS//exon       26404942//27773535
chr10:98336519-98336520(-) m6A CDS//exon       24209618//26404942//27773535
chr10:98337276-98337277(-) m6A exon//intron       24209618
chr10:98346496-98346497(-) m6A CDS//exon//intron       24209618//27371828//27773536
chr10:98346516-98346517(-) m6A CDS//intron       24209618//27371828//27773536

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-140-3p
Exosome HCC tissues     30542726
Exosome Primary dendritic cells|T cell line (J77)     21505438
Exosome Breast milk     22211110
Exosome Plasma     23663360
Exosome Colon cancer cell line (LIM1863)     25330373
Exosome Blood|B lymphoblastoid cells|Breast milk|Colon tissue|Endothelial cells|Epithelial cells|Lymphoma tissue|Mast cells|Seminal fluid|Tongue tissue     -
Microvesicle Plasma     23077538
Microvesicle Seminal plasma     23539611
Microvesicle Follicular fluid     23666971
Microvesicle Hepatoma cells     23771658
Microvesicle Blood|Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
Mitochondrion Skeletal muscle myoblasts     21637849
Mitochondrion Cell line (HEK-293|HeLa)     22984580
TM9SF3
Chromatin K562 cells     -
Cytosol K562 cells     -
Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -
Ribosome Colon cancer cells     24393600

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-140-3p
5-Fluorouracil 3385 Drug interaction    RC00006941
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-140-3p
Cisplatin 5702198       30980798
Paclitaxel 36314       30980798
Doxorubicin 31703       25698578
Doxorubicin 31703       30980798
Resource Symbol Drug Name PubChem ID
RNAactDrug hsa-miR-140-3p
Panobinostat       6918837
Topotecan       60700
l-685,458       5479543

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-140-3p
Interactor2: TM9SF3

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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