Basic Information:

  VIRBase ID:  

HHID00065862

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-140-3p:  MIMAT0004597          DDAH1:  NM_012137     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-140-3p	DDAH1
miRBase Accession/Entrez ID	MIMAT0004597	23576
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	DDAH//DDAH-1//DDAHI//HEL-S-16

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-140-3p	rs111366342 chr16:69933159    A/G rs1403836350 chr16:69933150    G/A rs771611815 chr16:69933160    C/T rs772662673 chr16:69933161    G/A

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	DDAH1	chr1:85866124(-) A-I      intronic chr1:85867942(-) A-I      intronic chr1:85867935(-) A-I      intronic chr1:85867930(-) A-I      intronic chr1:85867909(-) A-I      intronic chr1:85946959(-) A-I      intronic chr1:85867898(-) A-I      intronic chr1:85867884(-) A-I      intronic chr1:85867315(-) A-I      intronic chr1:85867261(-) A-I      intronic chr1:85866129(-) A-I      intronic chr1:85867255(-) A-I      intronic chr1:85863637(-) A-I      intronic chr1:85863642(-) A-I      intronic chr1:85862239(-) A-I      intronic chr1:85863718(-) A-I      intronic chr1:85865971(-) A-I      intronic chr1:85863666(-) A-I      intronic chr1:85863672(-) A-I      intronic chr1:85867267(-) A-I      intronic chr1:85863685(-) A-I      intronic chr1:85844315(-) A-I      intronic chr1:85878632(-) A-I      intronic chr1:85924208(-) A-I      intronic chr1:85865942(-) A-I      intronic chr1:85865964(-) A-I      intronic chr1:85866080(-) A-I      intronic chr1:85866088(-) A-I      intronic chr1:85866090(-) A-I      intronic chr1:85947062(-) A-I      intronic chr1:85867963(-) A-I      intronic chr1:85867948(-) A-I      intronic chr1:85866105(-) A-I      intronic chr1:85866106(-) A-I      intronic chr1:85946841(-) A-I      intronic chr1:85946853(-) A-I      intronic chr1:85946866(-) A-I      intronic chr1:85965246(-) A-I      intronic chr1:85965249(-) A-I      intronic chr1:85965250(-) A-I      intronic chr1:85965272(-) A-I      intronic chr1:86004898(-) A-I      intronic chr1:86004935(-) A-I      intronic chr1:86005012(-) A-I      intronic chr1:86005018(-) A-I      intronic chr1:85946408(-) A-I      intronic chr1:85862496(-) A-I      intronic chr1:85862602(-) A-I      intronic chr1:85865986(-) A-I      intronic chr1:85866081(-) A-I      intronic chr1:85866082(-) A-I      intronic chr1:85866083(-) A-I      intronic chr1:85866133(-) A-I      intronic chr1:85866142(-) A-I      intronic chr1:85867235(-) A-I      intronic chr1:85867275(-) A-I      intronic chr1:85867361(-) A-I      intronic chr1:85867475(-) A-I      intronic chr1:85884968(-) A-I      intronic chr1:85885114(-) A-I      intronic chr1:85926745(-) A-I      intronic chr1:85926753(-) A-I      intronic chr1:85946225(-) A-I      intronic chr1:85941720(-) A-I      intronic chr1:85948785(-) A-I      intronic chr1:85865999(-) A-I      intronic chr1:85946383(-) A-I      intronic chr1:85866031(-) A-I      intronic chr1:85867698(-) A-I      intronic chr1:85865864(-) A-I      intronic chr1:85948778(-) A-I      intronic chr1:85924250(-) A-I      intronic chr1:85880774(-) A-I      intronic chr1:85948797(-) A-I      intronic chr1:85880794(-) A-I      intronic chr1:85865980(-) A-I      intronic chr1:85880898(-) A-I      intronic chr1:85880381(-) A-I      intronic chr1:85946902(-) A-I      intronic chr1:85865967(-) A-I      intronic chr1:86006475(-) A-I      intronic chr1:85867254(-) A-I      intronic chr1:85867699(-) A-I      intronic chr1:85867792(-) A-I      intronic chr1:85948775(-) A-I      intronic chr1:86004941(-) A-I      intronic chr1:85956925(-) A-I      intronic chr1:86004897(-) A-I      intronic chr1:85867807(-) A-I      intronic chr1:85866029(-) A-I      intronic chr1:85867888(-) A-I      intronic chr1:85867899(-) A-I      intronic chr1:85880761(-) A-I      intronic chr1:85926728(-) A-I      intronic chr1:85867334(-) A-I      intronic chr1:85948798(-) A-I      intronic chr1:85926783(-) A-I      intronic chr1:85956931(-) A-I      intronic chr1:85948814(-) A-I      intronic chr1:86030347(-) A-I      intronic chr1:85948834(-) A-I      intronic chr1:86004926(-) A-I      intronic chr1:85865951(-) A-I      intronic chr1:86005121(-) A-I      intronic chr1:86004859(-) A-I      intronic chr1:86004819(-) A-I      intronic chr1:85868428(-) A-I      intronic chr1:85866166(-) A-I      intronic chr1:86004962(-) A-I      intronic chr1:85941641(-) A-I      intronic chr1:85948853(-) A-I      intronic chr1:86004958(-) A-I      intronic chr1:85867321(-) A-I      intronic chr1:85867298(-) A-I      intronic chr1:85946223(-) A-I      intronic chr1:85973172(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	DDAH1	chr1:85879853(-) T-C intron -    22484847 chr1:85867308(-) T-C intron -    22484847 chr1:85867686(-) T-C intron -    22484847 chr1:85868471(-) T-C intron -    22484847 chr1:85884960(-) T-C intron -    22484847 chr1:85892604(-) G-T intron -    22484847 chr1:85926783(-) A-G intron -    22484847 chr1:85970711(-) G-A intron -    22484847 chr1:85970786(-) T-C intron -    22484847 chr1:85999056(-) T-C intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	DDAH1	chr1:85786474-85786475(-) m6A 3'UTR//exon//intron       27773535 chr1:85786491-85786492(-) m6A 3'UTR//exon//intron       27773535 chr1:85786609-85786610(-) m6A 3'UTR//exon//intron       27773535 chr1:85787103-85787104(-) m6A 3'UTR//exon       24981863//27773535 chr1:85787141-85787142(-) m6A CDS//exon       24981863//27773535 chr1:85787200-85787201(-) m6A CDS//exon       24981863//27773535 chr1:85787231-85787232(-) m6A CDS//exon       24981863 chr1:85787239-85787240(-) m6A CDS//exon       24981863 chr1:85790451-85790452(-) m6A CDS//exon       24981863 chr1:85930510-85930511(-) m6A CDS//intron       24209618 chr1:85930774-85930775(-) m6A 5'UTR//intron       24209618//24981863 chr1:85960495-85960496(-) m6A intron       - chr1:85960549-85960550(-) m6A intron       - chr1:85960665-85960666(-) m6A intron       - chr1:85960689-85960690(-) m6A intron       - chr1:85960722-85960723(-) m6A intron       - chr1:85960779-85960780(-) m6A intron       - chr1:85960830-85960831(-) m6A intron       - chr1:85960838-85960839(-) m6A intron       - chr1:85960863-85960864(-) m6A intron       - chr1:85960871-85960872(-) m6A intron       - chr1:85960890-85960891(-) m6A intron       - chr1:85960899-85960900(-) m6A intron       - chr1:85961013-85961014(-) m6A intron       24981863 chr1:85961034-85961035(-) m6A intron       24981863 chr1:85961172-85961173(-) m6A intron       24209618 chr1:85961212-85961213(-) m6A intron       24209618//24981863 chr1:85961229-85961230(-) m6A intron       24209618//24981863 chr1:85961354-85961355(-) m6A intron       24209618//24981863 chr1:85961393-85961394(-) m6A intron       24209618//24981863 chr1:86043695-86043696(-) m6A 5'UTR//exon       24981863 chr1:86043760-86043761(-) m6A 5'UTR//exon       24981863 chr1:86043771-86043772(-) m6A 5'UTR//exon       24981863 chr1:86043799-86043800(-) m6A 5'UTR//exon       24981863 chr1:86043884-86043885(-) m6A 5'UTR//exon       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-140-3p	Exosome HCC tissues     30542726 Exosome Primary dendritic cells|T cell line (J77)     21505438 Exosome Breast milk     22211110 Exosome Plasma     23663360 Exosome Colon cancer cell line (LIM1863)     25330373 Exosome Blood|B lymphoblastoid cells|Breast milk|Colon tissue|Endothelial cells|Epithelial cells|Lymphoma tissue|Mast cells|Seminal fluid|Tongue tissue     - Microvesicle Plasma     23077538 Microvesicle Seminal plasma     23539611 Microvesicle Follicular fluid     23666971 Microvesicle Hepatoma cells     23771658 Microvesicle Blood|Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     - Mitochondrion Skeletal muscle myoblasts     21637849 Mitochondrion Cell line (HEK-293|HeLa)     22984580
	DDAH1	Cytosol HeLa-S3 cells     - Exosome Blood     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells     - Ribosome Colon cancer cells     24393600

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-140-3p	5-Fluorouracil 3385 Drug interaction    RC00006941

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-140-3p	Cisplatin 5702198       30980798 Paclitaxel 36314       30980798 Doxorubicin 31703       25698578 Doxorubicin 31703       30980798

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	hsa-miR-140-3p	Panobinostat       6918837 Topotecan       60700 l-685,458       5479543

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-140-3p
Interactor2: DDAH1

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.