Basic Information:

  VIRBase ID:  

HHID00065733

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-30b-3p:  MIMAT0004589          VPS54:  NM_001005739     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-30b-3p	VPS54
miRBase Accession/Entrez ID	MIMAT0004589	51542
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	HCC8//hVps54L//PPP1R164//SLP-8p//VPS54L//WR

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-30b-3p	rs1160794252 chr8:134800541    A/G rs761170520 chr8:134800545    A/C rs776207215 chr8:134800535    G/GT rs1293522812 chr8:134800547    C/T rs1407185230 chr8:134800550    C/T rs1435060162 chr8:134800546    C/T rs766838703 chr8:134800548    T/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	VPS54	chr2:64169046(-) A-I      intronic chr2:64127297(-) A-I      intronic chr2:64238528(-) A-I      intronic chr2:64238534(-) A-I      intronic chr2:64180468(-) A-I      intronic chr2:64180480(-) A-I      intronic chr2:64180485(-) A-I      intronic chr2:64180494(-) A-I      intronic chr2:64199828(-) A-I      intronic chr2:64180504(-) A-I      intronic chr2:64168564(-) A-I      intronic chr2:64238653(-) A-I      intronic chr2:64180518(-) A-I      intronic chr2:64168574(-) A-I      intronic chr2:64180531(-) A-I      intronic chr2:64243815(-) A-I      intronic chr2:64233891(-) A-I      intronic chr2:64244289(-) A-I      intronic chr2:64233850(-) A-I      intronic chr2:64233849(-) A-I      intronic chr2:64233829(-) A-I      intronic chr2:64199837(-) A-I      intronic chr2:64168515(-) A-I      intronic chr2:64166449(-) A-I      intronic chr2:64166419(-) A-I      intronic chr2:64166376(-) A-I      intronic chr2:64128115(-) A-I      intronic chr2:64128114(-) A-I      intronic chr2:64128099(-) A-I      intronic chr2:64169002(-) A-I      intronic chr2:64169020(-) A-I      intronic chr2:64237271(-) A-I      intronic chr2:64237078(-) A-I      intronic chr2:64237073(-) A-I      intronic chr2:64233885(-) A-I      intronic chr2:64233864(-) A-I      intronic chr2:64212209(-) A-I      intronic chr2:64205930(-) A-I      intronic chr2:64204111(-) A-I      intronic chr2:64203965(-) A-I      intronic chr2:64203963(-) A-I      intronic chr2:64203960(-) A-I      intronic chr2:64203473(-) A-I      intronic chr2:64203441(-) A-I      intronic chr2:64203423(-) A-I      intronic chr2:64203399(-) A-I      intronic chr2:64203372(-) A-I      intronic chr2:64203049(-) A-I      intronic chr2:64199820(-) A-I      intronic chr2:64199815(-) A-I      intronic chr2:64180542(-) A-I      intronic chr2:64180486(-) A-I      intronic chr2:64180484(-) A-I      intronic chr2:64180483(-) A-I      intronic chr2:64180320(-) A-I      intronic chr2:64169164(-) A-I      intronic chr2:64128123(-) A-I      intronic chr2:64203479(-) A-I      intronic chr2:64169121(-) A-I      intronic chr2:64169056(-) A-I      intronic chr2:64169049(-) A-I      intronic chr2:64168518(-) A-I      intronic chr2:64167132(-) A-I      intronic chr2:64167124(-) A-I      intronic chr2:64167119(-) A-I      intronic chr2:64127267(-) A-I      intronic chr2:64167108(-) A-I      intronic chr2:64167062(-) A-I      intronic chr2:64167027(-) A-I      intronic chr2:64167023(-) A-I      intronic chr2:64166971(-) A-I      intronic chr2:64166462(-) A-I      intronic chr2:64129033(-) A-I      intronic chr2:64128897(-) A-I      intronic chr2:64128893(-) A-I      intronic chr2:64128887(-) A-I      intronic chr2:64128078(-) A-I      intronic chr2:64166394(-) A-I      intronic chr2:64166340(-) A-I      intronic chr2:64127268(-) A-I      intronic chr2:64127999(-) A-I      intronic chr2:64128074(-) A-I      intronic chr2:64128075(-) A-I      intronic chr2:64166326(-) A-I      intronic chr2:64166303(-) A-I      intronic chr2:64166302(-) A-I      intronic chr2:64166282(-) A-I      intronic chr2:64165863(-) A-I      intronic chr2:64165815(-) A-I      intronic chr2:64165792(-) A-I      intronic chr2:64165767(-) A-I      intronic chr2:64165763(-) A-I      intronic chr2:64165745(-) A-I      intronic chr2:64165666(-) A-I      intronic chr2:64165389(-) A-I      intronic chr2:64129110(-) A-I      intronic chr2:64129041(-) A-I      intronic chr2:64244389(-) A-I      intronic chr2:64127285(-) A-I      intronic chr2:64244312(-) A-I      intronic chr2:64243947(-) A-I      intronic chr2:64243920(-) A-I      intronic chr2:64243919(-) A-I      intronic chr2:64243916(-) A-I      intronic chr2:64243808(-) A-I      intronic chr2:64243806(-) A-I      intronic chr2:64243803(-) A-I      intronic chr2:64243800(-) A-I      intronic chr2:64243792(-) A-I      intronic chr2:64243775(-) A-I      intronic chr2:64238618(-) A-I      intronic chr2:64236521(-) A-I      intronic chr2:64199854(-) A-I      intronic chr2:64180398(-) A-I      intronic chr2:64166925(-) A-I      intronic chr2:64237011(-) A-I      intronic chr2:64166430(-) A-I      intronic chr2:64203375(-) A-I      intronic chr2:64232198(-) A-I      intronic chr2:64180394(-) A-I      intronic chr2:64227011(-) A-I      intronic chr2:64169105(-) A-I      intronic chr2:64166406(-) A-I      intronic chr2:64232290(-) A-I      intronic chr2:64232510(-) A-I      intronic chr2:64168435(-) A-I      intronic chr2:64232405(-) A-I      intronic chr2:64180517(-) A-I      intronic chr2:64232366(-) A-I      intronic chr2:64232487(-) A-I      intronic chr2:64166343(-) A-I      intronic chr2:64165781(-) A-I      intronic chr2:64244032(-) A-I      intronic chr2:64148896(-) A-I      intronic chr2:64232376(-) A-I      intronic chr2:64232334(-) A-I      intronic chr2:64168923(-) A-I      intronic chr2:64232111(-) A-I      intronic chr2:64200813(-) A-I      intronic chr2:64166962(-) A-I      intronic chr2:64232412(-) A-I      intronic chr2:64232402(-) A-I      intronic chr2:64232416(-) A-I      intronic chr2:64237208(-) A-I      intronic chr2:64236629(-) A-I      intronic chr2:64168559(-) A-I      intronic chr2:64232432(-) A-I      intronic chr2:64200839(-) A-I      intronic chr2:64166454(-) A-I      intronic chr2:64243819(-) A-I      intronic chr2:64203352(-) A-I      intronic chr2:64169085(-) A-I      intronic chr2:64238445(-) A-I      intronic chr2:64206441(-) A-I      intronic chr2:64232461(-) A-I      intronic chr2:64243985(-) A-I      intronic chr2:64232442(-) A-I      intronic chr2:64232471(-) A-I      intronic chr2:64232504(-) A-I      intronic chr2:64212193(-) A-I      intronic chr2:64241163(-) A-I      intronic chr2:64232408(-) A-I      intronic chr2:64232349(-) A-I      intronic chr2:64243951(-) A-I      intronic chr2:64232310(-) A-I      intronic chr2:64186816(-) A-I      intronic chr2:64168598(-) A-I      intronic chr2:64127291(-) A-I      intronic chr2:64238674(-) A-I      intronic chr2:64127321(-) A-I      intronic chr2:64199823(-) A-I      intronic chr2:64203328(-) A-I      intronic chr2:64212236(-) A-I      intronic chr2:64203400(-) A-I      intronic chr2:64200757(-) A-I      intronic chr2:64167001(-) A-I      intronic chr2:64238617(-) A-I      intronic chr2:64241153(-) A-I      intronic chr2:64180377(-) A-I      intronic chr2:64206530(-) A-I      intronic chr2:64136686(-) A-I      intronic chr2:64244438(-) A-I      intronic chr2:64168503(-) A-I      intronic chr2:64238673(-) A-I      intronic chr2:64168611(-) A-I      intronic chr2:64237158(-) A-I      intronic chr2:64244219(-) A-I      intronic chr2:64168640(-) A-I      intronic chr2:64244359(-) A-I      intronic chr2:64200753(-) A-I      intronic chr2:64169005(-) A-I      intronic chr2:64180430(-) A-I      intronic chr2:64166358(-) A-I      intronic chr2:64168562(-) A-I      intronic chr2:64237081(-) A-I      intronic chr2:64203376(-) A-I      intronic chr2:64166991(-) A-I      intronic chr2:64166382(-) A-I      intronic chr2:64238537(-) A-I      intronic chr2:64165778(-) A-I      intronic chr2:64166963(-) A-I      intronic chr2:64243810(-) A-I      intronic chr2:64243922(-) A-I      intronic chr2:64148813(-) A-I      intronic chr2:64166424(-) A-I      intronic chr2:64238467(-) A-I      intronic chr2:64165386(-) A-I      intronic chr2:64203072(-) A-I      intronic chr2:64166926(-) A-I      intronic chr2:64168912(-) A-I      intronic chr2:64180433(-) A-I      intronic chr2:64180442(-) A-I      intronic chr2:64238578(-) A-I      intronic chr2:64187341(-) A-I      intronic chr2:64244015(-) A-I      intronic chr2:64236627(-) A-I      intronic chr2:64237192(-) A-I      intronic chr2:64166423(-) A-I      intronic chr2:64166338(-) A-I      intronic chr2:64243921(-) A-I      intronic chr2:64168431(-) A-I      intronic chr2:64128025(-) A-I      intronic chr2:64169073(-) A-I      intronic chr2:64206511(-) A-I      intronic chr2:64166459(-) A-I      intronic chr2:64206488(-) A-I      intronic chr2:64167068(-) A-I      intronic chr2:64167071(-) A-I      intronic chr2:64166992(-) A-I      intronic chr2:64168389(-) A-I      intronic chr2:64167070(-) A-I      intronic chr2:64206549(-) A-I      intronic chr2:64236574(-) A-I      intronic chr2:64237249(-) A-I      intronic chr2:64237114(-) A-I      intronic chr2:64128044(-) A-I      intronic chr2:64199775(-) A-I      intronic chr2:64167006(-) A-I      intronic chr2:64200842(-) A-I      intronic chr2:64236591(-) A-I      intronic chr2:64167056(-) A-I      intronic chr2:64165777(-) A-I      intronic chr2:64237052(-) A-I      intronic chr2:64167069(-) A-I      intronic chr2:64165354(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	VPS54	chr2:64120358(-) A-I exon 3'UTR    15342557 chr2:64120552(-) A-I exon 3'UTR    15342557 chr2:64147596(-) A-I exon CDS    15342557 chr2:64147598(-) A-I exon CDS    15342557 chr2:64147645(-) A-I exon CDS    15342557 chr2:64147703(-) A-I exon CDS    15342557 chr2:64148407(-) A-I exon CDS    15342557 chr2:64176195(-) A-I exon CDS    15342557 chr2:64199369(-) A-I exon CDS    15342557 chr2:64208969(-) A-I exon CDS    15342557 chr2:64168560(-) A-I intron -    22327324 chr2:64232290(-) A-I intron -    22028664 chr2:64232310(-) A-I intron -    22028664 chr2:64232334(-) A-I intron -    22028664 chr2:64232349(-) A-I intron -    22028664 chr2:64232366(-) A-I intron -    22028664 chr2:64232376(-) A-I intron -    22028664 chr2:64232382(-) A-I intron -    22028664 chr2:64232402(-) A-I intron -    22028664 chr2:64232405(-) A-I intron -    22028664 chr2:64232408(-) A-I intron -    22028664 chr2:64232412(-) A-I intron -    22028664 chr2:64232416(-) A-I intron -    22028664 chr2:64232432(-) A-I intron -    22028664 chr2:64232442(-) A-I intron -    22028664 chr2:64232461(-) A-I intron -    22028664 chr2:64232471(-) A-I intron -    22028664 chr2:64232487(-) A-I intron -    22028664 chr2:64232504(-) A-I intron -    22028664 chr2:64232510(-) A-I intron -    22028664 chr2:64167745(-) A-I intron -    21960545 chr2:64167831(-) A-I intron -    21960545 chr2:64168640(-) A-I intron -    21960545 chr2:64168923(-) A-I intron -    21960545 chr2:64173491(-) A-I intron -    21960545 chr2:64191059(-) A-I intron -    21960545 chr2:64236588(-) A-I intron -    21960545 chr2:64237317(-) A-I intron -    21960545 chr2:64173430(-) A-G intron -    22484847 chr2:64173446(-) A-G intron -    22484847 chr2:64213961(-) G-A intron -    22484847 chr2:64150442(-) T-C intron -    22484847 chr2:64165778(-) A-G intron -    22484847 chr2:64166308(-) A-G intron -    22484847 chr2:64166338(-) A-G intron -    22484847 chr2:64166343(-) A-G intron -    22484847 chr2:64166358(-) A-G intron -    22484847 chr2:64166406(-) A-G intron -    22484847 chr2:64166423(-) A-G intron -    22484847 chr2:64166430(-) A-G intron -    22484847 chr2:64166454(-) A-G intron -    22484847 chr2:64166459(-) A-G intron -    22484847 chr2:64166962(-) A-G intron -    22484847 chr2:64166963(-) A-G intron -    22484847 chr2:64166992(-) A-G intron -    22484847 chr2:64167001(-) A-G intron -    22484847 chr2:64167006(-) A-G intron -    22484847 chr2:64167056(-) A-G intron -    22484847 chr2:64167068(-) A-G intron -    22484847 chr2:64167069(-) A-G intron -    22484847 chr2:64167070(-) A-G intron -    22484847 chr2:64167071(-) A-G intron -    22484847 chr2:64167118(-) A-G intron -    22484847 chr2:64168389(-) A-G intron -    22484847 chr2:64168435(-) A-G intron -    22484847 chr2:64168513(-) A-G intron -    22484847 chr2:64168559(-) A-G intron -    22484847 chr2:64168560(-) A-G intron -    22484847 chr2:64168598(-) A-G intron -    22484847 chr2:64168612(-) A-G intron -    22484847 chr2:64168640(-) A-G intron -    22484847 chr2:64168923(-) A-G intron -    22484847 chr2:64168976(-) A-G intron -    22484847 chr2:64168985(-) A-G intron -    22484847 chr2:64169052(-) A-G intron -    22484847 chr2:64169073(-) A-G intron -    22484847 chr2:64169085(-) A-G intron -    22484847 chr2:64187341(-) A-G intron -    22484847 chr2:64203072(-) A-G intron -    22484847 chr2:64203400(-) A-G intron -    22484847 chr2:64203417(-) A-G intron -    22484847 chr2:64203478(-) A-G intron -    22484847 chr2:64212233(-) A-G intron -    22484847 chr2:64236521(-) A-G intron -    22484847 chr2:64236574(-) A-G intron -    22484847 chr2:64236588(-) A-G intron -    22484847 chr2:64237011(-) A-G intron -    22484847 chr2:64237149(-) A-G intron -    22484847 chr2:64237152(-) A-G intron -    22484847 chr2:64237158(-) A-G intron -    22484847 chr2:64237248(-) A-G intron -    22484847 chr2:64237249(-) A-G intron -    22484847 chr2:64238544(-) G-A intron -    22484847 chr2:64238578(-) A-G intron -    22484847 chr2:64238600(-) A-G intron -    22484847 chr2:64241082(-) A-G intron -    22484847 chr2:64241142(-) A-G intron -    22484847 chr2:64241153(-) A-G intron -    22484847 chr2:64243810(-) A-G intron -    22484847 chr2:64243819(-) A-G intron -    22484847 chr2:64243832(-) A-G intron -    22484847 chr2:64243922(-) A-G intron -    22484847 chr2:64243951(-) A-G intron -    22484847 chr2:64243998(-) A-G intron -    22484847 chr2:64244359(-) A-G intron -    22484847 chr2:64244371(-) A-G intron -    22484847 chr2:64244388(-) A-G intron -    22484847 chr2:64244424(-) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	VPS54	chr2:64119316-64119317(-) m6A 3'UTR       27773535 chr2:64119404-64119405(-) m6A 3'UTR       27773535 chr2:64119540-64119541(-) m6A 3'UTR       24981863//27773535//22608085 chr2:64119586-64119587(-) m6A 3'UTR       24981863//27773535//22608085 chr2:64119595-64119596(-) m6A 3'UTR       24981863//27773535//22608085 chr2:64119600-64119601(-) m6A 3'UTR       24981863//27773535//22608085 chr2:64119611-64119612(-) m6A 3'UTR       24981863 chr2:64119617-64119618(-) m6A 3'UTR       24981863 chr2:64120278-64120279(-) m6A 3'UTR       24209618//25456834//24981863//27773535//22608085 chr2:64120293-64120294(-) m6A 3'UTR       24209618//25456834//24981863//27773535//22608085 chr2:64120313-64120314(-) m6A 3'UTR       24209618//25456834//24981863//27773535//22608085 chr2:64120412-64120413(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22608085 chr2:64120457-64120458(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr2:64120468-64120469(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr2:64120475-64120476(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr2:64120548-64120549(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//27371828//22608085 chr2:64120600-64120601(-) m6A 3'UTR//CDS       24284625//24981863//27773535//27371828//22608085 chr2:64124640-64124641(-) m6A 3'UTR//CDS       22608085 chr2:64147054-64147055(-) Cm CDS       - chr2:64174618-64174619(-) m6A CDS//intron       27773535 chr2:64176203-64176204(-) m6A CDS       27773535 chr2:64176263-64176264(-) m6A CDS       24209618//24981863//27773535//22608085 chr2:64189214-64189215(-) m6A CDS       24284625//24209618//24981863//26404942//27773535//22608085 chr2:64189251-64189252(-) m6A CDS       24284625//24209618//24981863//26404942//27773535//22608085 chr2:64189306-64189307(-) m6A CDS       24284625//24209618//24981863//28052920//26404942//27773535//22608085 chr2:64189376-64189377(-) m6A CDS       24284625//24209618//24981863//28052920//26404942//27773535//22575960//22608085 chr2:64189459-64189460(-) m6A CDS       24284625//24981863//22608085 chr2:64189471-64189472(-) Y CDS       26075521 chr2:64189473-64189474(-) m6A CDS       24284625//24981863//22608085 chr2:64189545-64189546(-) m6A CDS       24284625//22608085 chr2:64208812-64208813(-) m6A CDS       27773535 chr2:64208858-64208859(-) m6A CDS       27773535 chr2:64208867-64208868(-) m6A CDS       27773535 chr2:64208880-64208881(-) m6A CDS       27773535 chr2:64208964-64208965(-) m6A CDS       27773535 chr2:64211004-64211005(-) m6A CDS       27773535 chr2:64211049-64211050(-) m6A CDS       27773535 chr2:64246078-64246079(-) m6A 5'UTR       24209618 chr2:64246201-64246202(-) m6A 5'UTR       24209618

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-30b-3p	Exosome Breast milk     22211110 Exosome Plasma     23663360 Exosome Human mast cell line (HMC-1)     24009880 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Seminal plasma     23539611 Microvesicle Fibroblasts|Mesenchymal stem cells|Urine     -
	VPS54	Chromatin K562 cells     - Cytosol HCC cell line (HepG2)|K562 cells     - Exosome Blood     - Membrane HCC cell line (HepG2)     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-30b-3p
Interactor2: VPS54

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	CDS
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.